Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation

2017 ◽  
Vol 31 ◽  
pp. 67-74 ◽  
Author(s):  
Kathrin Fuhrmann ◽  
Gregor Fuhrmann
Keyword(s):  
Oral Delivery ◽  
Recent Advances ◽  
Macromolecular Drugs ◽  
Polymer Conjugation

Recent Advances in the Oral Delivery of Insulin

2014 ◽  
Vol 8 (2) ◽  
pp. 155-159 ◽  
Author(s):  
Rekha Ramesan ◽  
Chandra Sharma
Keyword(s):  
Oral Delivery ◽  
Recent Advances

Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

2013 ◽  
Vol 65 (6) ◽  
pp. 865-879 ◽  
Author(s):  
Mei-Chin Chen ◽  
Fwu-Long Mi ◽  
Zi-Xian Liao ◽  
Chun-Wen Hsiao ◽  
Kiran Sonaje ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Recent Advances

Thiomers for oral delivery of hydrophilic macromolecular drugs

2004 ◽  
Vol 1 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Andreas Bernkop-Schnürch ◽  
Martin H Hoffer ◽  
Krum Kafedjiiski
Keyword(s):  
Oral Delivery ◽  
Macromolecular Drugs

Trends in liposomal nanocarrier strategies for the oral delivery of biologics

Nanomedicine ◽  
2021 ◽  
Author(s):  
Eric Mühlberg ◽  
Mira Burtscher ◽  
Florian Umstätter ◽  
Gert Fricker ◽  
Walter Mier ◽  
...  
Keyword(s):  
Oral Administration ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Parenteral Delivery ◽  
Liposomal Formulations ◽  
Macromolecular Drugs ◽  
Vital Interest ◽  
Delivery Platform ◽  
Delivery Vehicles

The number of approved macromolecular drugs such as peptides, proteins and antibodies steadily increases. Since drugs with high molecular weight are commonly not suitable for oral delivery, research on carrier strategies enabling oral administration is of vital interest. In past decades, nanocarriers, in particular liposomes, have been exhaustively investigated as oral drug-delivery platform. Despite their successful application as parenteral delivery vehicles, liposomes have up to date not succeeded for oral administration. However, a plenitude of approaches aiming to increase the oral bioavailability of macromolecular drugs administered by liposomal formulations has been published. Here, we summarize the strategies published in the last 10 years (vaccine strategies excluded) with a main focus on strategies proven efficient in animal models.

Recent advances in mechanical force-assisted transdermal delivery of macromolecular drugs

2021 ◽  
Vol 602 ◽  
pp. 120598
Author(s):  
Ruxuan Wang ◽  
Qiong Bian ◽  
Yihua Xu ◽  
Donghang Xu ◽  
Jianqing Gao
Keyword(s):  
Transdermal Delivery ◽  
Mechanical Force ◽  
Recent Advances ◽  
Macromolecular Drugs

Toxicity evaluation of nanocarriers for the oral delivery of macromolecular drugs

2015 ◽  
Vol 97 ◽  
pp. 206-217 ◽  
Author(s):  
P. Ojer ◽  
T. Iglesias ◽  
A. Azqueta ◽  
J.M. Irache ◽  
A. López de Cerain
Keyword(s):  
Oral Delivery ◽  
Toxicity Evaluation ◽  
Macromolecular Drugs
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