Recent advances in mechanical force-assisted transdermal delivery of macromolecular drugs

2021 ◽  
Vol 602 ◽  
pp. 120598
Author(s):  
Ruxuan Wang ◽  
Qiong Bian ◽  
Yihua Xu ◽  
Donghang Xu ◽  
Jianqing Gao
Keyword(s):  
Transdermal Delivery ◽  
Mechanical Force ◽  
Recent Advances ◽  
Macromolecular Drugs

scholarly journals Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

2021 ◽  
Author(s):  
Ting Liu ◽  
Minglong Chen ◽  
Jintao Fu ◽  
Ying Sun ◽  
Chao Lu ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Peptide Drugs ◽  
Recent Advances

scholarly journals Ultrasound-enhanced transdermal delivery: recent advances and future challenges

2014 ◽  
Vol 5 (7) ◽  
pp. 843-857 ◽  
Author(s):  
Matthias A Oberli ◽  
Carl M Schoellhammer ◽  
Robert Langer ◽  
Daniel Blankschtein
Keyword(s):  
Transdermal Delivery ◽  
Recent Advances ◽  
Future Challenges

scholarly journals Recent Advances in Nanomaterials for Dermal and Transdermal Applications

2021 ◽  
Vol 5 (1) ◽  
pp. 18
Author(s):  
Amani Zoabi ◽  
Elka Touitou ◽  
Katherine Margulis
Keyword(s):  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Polymeric Nanoparticles ◽  
Skin Permeation ◽  
Superficial Layer ◽  
The Body ◽  
Local Concentration ◽  
Cosmetic Products ◽  
Recent Advances ◽  
The Stability

The stratum corneum, the most superficial layer of the skin, protects the body against environmental hazards and presents a highly selective barrier for the passage of drugs and cosmetic products deeper into the skin and across the skin. Nanomaterials can effectively increase the permeation of active molecules across the stratum corneum and enable their penetration into deeper skin layers, often by interacting with the skin and creating the distinct sites with elevated local concentration, acting as reservoirs. The flux of the molecules from these reservoirs can be either limited to the underlying skin layers (for topical drug and cosmeceutical delivery) or extended across all the sublayers of the epidermis to the blood vessels of the dermis (for transdermal delivery). The type of the nanocarrier and the physicochemical nature of the active substance are among the factors that determine the final skin permeation pattern and the stability of the penetrant in the cutaneous environment. The most widely employed types of nanomaterials for dermal and transdermal applications include solid lipid nanoparticles, nanovesicular carriers, microemulsions, nanoemulsions, and polymeric nanoparticles. The recent advances in the area of nanomaterial-assisted dermal and transdermal delivery are highlighted in this review.

Recent Advances in the Transdermal Delivery of Protein Therapeutics with a Combinatorial System of Chemical Adjuvants and Physical Penetration Enhancements

2020 ◽  
Vol 3 (2) ◽  
pp. 1900116 ◽  
Author(s):  
Young‐Hyeon An ◽  
Mihn Jeong Park ◽  
Joon Lee ◽  
Junghyeon Ko ◽  
Su‐Hwan Kim ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Protein Therapeutics ◽  
Recent Advances ◽  
Combinatorial System

Laser ablation-enhanced transdermal drug delivery

2013 ◽  
Vol 2 (4) ◽  
Author(s):  
Yajuan Li ◽  
Liangran Guo ◽  
Wei Lu
Keyword(s):  
Drug Delivery ◽  
Laser Ablation ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Penetration ◽  
Macromolecular Drugs ◽  
Alternative Approach ◽  
Selective Photothermolysis ◽  
Transcutaneous Drug Delivery ◽  
Critical Challenge

Abstract:Transdermal delivery offers an excellent route for drug and vaccine administration. Nonetheless, the lipid-rich outer stratum corneum layer of the skin presents a critical challenge to drug penetration. Laser ablation perforates epidermis through selective photothermolysis, making skin more permeable to hydrophilic and macromolecular drugs such as peptides, proteins, and genes. This review summarizes recent applications to laser ablation-enhanced transdermal delivery. Needle- and pain-free transcutaneous drug delivery via laser ablation provides an alternative approach to achieve local or systemic therapeutics.

Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

2012 ◽  
Vol 7 (3) ◽  
pp. 184-197 ◽  
Author(s):  
HJessy Shaji ◽  
Dhanila Varkey
Keyword(s):  
Transdermal Delivery ◽  
Fluorescent Dyes ◽  
Skin Barrier ◽  
Penetration Enhancement ◽  
Transport Barrier ◽  
Novel Technologies ◽  
Combination Strategies ◽  
Recent Advances ◽  
Transdermal Drug Delivery Systems ◽  
Transdermal Penetration

Transdermal delivery offers opportunities for inventive, challenging and valuable research with patient benefits. However, the prominent challenge in designing transdermal drug delivery systems is to overcome the natural transport barrier of the skin, the stratum corneum. Several physical and chemical enhancement techniques have been investigated in the last decade to breach the skin barrier and assist the transport of macromolecules across skin. Recent technological advances in this field include novel combination strategies of penetration enhancement techniques, microneedle array designs, needle-free technologies, nanocarriers, metered dose and microstructured transdermal systems. The present review reports on recent advances in physical approaches towards enhanced transdermal penetration. Enhancement strategies comprehensively covered in this review emphasize the significant achievements gained through successful transdermal delivery of hydrophilic macromolecules, vaccines, proteins, peptides, oligonucleotides, fluorescent dyes and plasmid delivery. Some commercially available technologies for transdermal delivery have also been covered. These novel technologies hold immense potential to advance further into clinical practice and enable better therapeutic applications and prophylactic interventions for various diseases.

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