Quantitative systems pharmacology in model-informed drug development and therapeutic use

Current Opinion in Systems Biology ◽

10.1016/j.coisb.2018.05.003 ◽

2018 ◽

Vol 10 ◽

pp. 19-25

Author(s):

Sebastian G. Wicha ◽

Charlotte Kloft

Keyword(s):

Drug Development ◽

Therapeutic Use ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology

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Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12426 ◽

2019 ◽

Vol 8 (6) ◽

pp. 380-395 ◽

Author(s):

Gabriel Helmlinger ◽

Victor Sokolov ◽

Kirill Peskov ◽

Karen M. Hallow ◽

Yuri Kosinsky ◽

...

Keyword(s):

Drug Development ◽

Model Building ◽

Exemplar Model ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Oncology Drug ◽

Oncology Drug Development

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Quantitative Systems Pharmacology: Applications and Adoption in Drug Development

Systems Pharmacology and Pharmacodynamics - AAPS Advances in the Pharmaceutical Sciences Series ◽

10.1007/978-3-319-44534-2_3 ◽

2016 ◽

pp. 27-52 ◽

Author(s):

Saroja Ramanujan ◽

Kapil Gadkar ◽

Ananth Kadambi

Keyword(s):

Drug Development ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology

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Systems pharmacology in drug development and therapeutic use — A forthcoming paradigm shift

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2016.07.014 ◽

2016 ◽

Vol 94 ◽

pp. 1-3 ◽

Author(s):

Charlotte Kloft ◽

Miriam N. Trame ◽

Christoph A. Ritter

Keyword(s):

Drug Development ◽

Paradigm Shift ◽

Therapeutic Use ◽

Systems Pharmacology

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Quantitative Systems Pharmacology Modeling of PBMC-Humanized Mouse to Facilitate Preclinical Immuno-oncology Drug Development

ACS Pharmacology & Translational Science ◽

10.1021/acsptsci.0c00178 ◽

2020 ◽

Author(s):

Huilin Ma ◽

Minu Pilvankar ◽

Jun Wang ◽

Craig Giragossian ◽

Aleksander S. Popel

Keyword(s):

Drug Development ◽

Systems Pharmacology ◽

Humanized Mouse ◽

Quantitative Systems Pharmacology ◽

Oncology Drug ◽

Oncology Drug Development

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Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12504 ◽

2020 ◽

Vol 9 (4) ◽

pp. 195-197

Author(s):

Flora T. Musuamba ◽

Roberta Bursi ◽

Efthymios Manolis ◽

Kristin Karlsson ◽

Alexander Kulesza ◽

...

Keyword(s):

Drug Development ◽

In Silico ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

In Silico Models

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Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices

The AAPS Journal ◽

10.1208/s12248-019-0339-5 ◽

2019 ◽

Vol 21 (4) ◽

Author(s):

Jane P. F. Bai ◽

Justin C. Earp ◽

Venkateswaran C. Pillai

Keyword(s):

Drug Development ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

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PCN47 INTEGRATION OF QUANTITATIVE SYSTEMS PHARMACOLOGY AND HEALTH ECONOMICS MODELS FOR DRUG DEVELOPMENT DECISION MAKING: APPLICATION TO TREATMENT OF SKELETAL RELATED EVENTS IN PATIENTS WITH BONE METASTASES

Value in Health ◽

10.1016/j.jval.2020.04.1551 ◽

2020 ◽

Vol 23 ◽

pp. S31

Author(s):

M. Gastonguay ◽

M. Riggs ◽

M. Johnson

Keyword(s):

Decision Making ◽

Health Economics ◽

Drug Development ◽

Bone Metastases ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Skeletal Related Events

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FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective

The AAPS Journal ◽

10.1208/s12248-021-00585-x ◽

2021 ◽

Vol 23 (3) ◽

Author(s):

Jane P. F. Bai ◽

Brian J. Schmidt ◽

Kapil G. Gadkar ◽

Valeriu Damian ◽

Justin C. Earp ◽

...

Keyword(s):

Drug Development ◽

Future Perspective ◽

Meeting Report ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Clinical Drug Development ◽

Scientific Exchange ◽

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Innovative approaches in CNS clinical drug development: Quantitative systems pharmacology

Therapies ◽

10.1016/j.therap.2020.12.007 ◽

2020 ◽

Author(s):

Clémence Lacroix ◽

Thomas Soeiro ◽

Marguerite Le Marois ◽

Romain Guilhaumou ◽

Catherine Cassé-Perrot ◽

...

Keyword(s):

Drug Development ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Clinical Drug Development ◽

Clinical Drug ◽

Innovative Approaches

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A quantitative systems pharmacology model of colonic motility with applications in drug development

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-019-09651-6 ◽

2019 ◽

Vol 46 (5) ◽

pp. 485-498

Author(s):

Raibatak Das ◽

Lucia Wille ◽

Liming Zhang ◽

Chunlin Chen ◽

Wendy Winchester ◽

...

Keyword(s):

Drug Development ◽

Colonic Motility ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Systems Pharmacology Model

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