Hyaluronic acid and chitosan-DNA complex multilayered thin film as surface-mediated nonviral gene delivery system

2009 ◽  
Vol 74 (1) ◽  
pp. 298-303 ◽  
Author(s):  
Quan-Kui Lin ◽  
Ke-Feng Ren ◽  
Jian Ji
Keyword(s):  
Thin Film ◽  
Hyaluronic Acid ◽  
Gene Delivery ◽  
Delivery System ◽  
Nonviral Gene Delivery ◽  
Gene Delivery System ◽  
Multilayered Thin Film ◽  
Dna Complex

Reduction-Sensitive Lipopolyamines as a Novel Nonviral Gene Delivery System for Modulated Release of DNA with Improved Transgene Expression

2000 ◽  
Vol 43 (23) ◽  
pp. 4377-4387 ◽  
Author(s):  
Gerardo Byk ◽  
Barbara Wetzer ◽  
Marc Frederic ◽  
Catherine Dubertret ◽  
Bruno Pitard ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transgene Expression ◽  
Nonviral Gene Delivery ◽  
Gene Delivery System

Transdermal Delivery of Poly-Hyaluronic Acid-Based Spherical Nucleic Acids for Chemogene Therapy

Nanoscale ◽  
2022 ◽  
Author(s):  
Kai Jiang ◽  
Di Zhao ◽  
Rui Ye ◽  
Xinlong Liu ◽  
Chao Gao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nucleic Acid ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Gene Delivery System ◽  
Transdermal Administration ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorders treatment. However, most of traditional SNA core materials are...

scholarly journals 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins

Gene Therapy ◽  
2001 ◽  
Vol 8 (10) ◽  
pp. 795-803 ◽  
Author(s):  
L K Medina-Kauwe ◽  
N Kasahara ◽  
L Kedes
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Nonviral Gene Delivery ◽  
Gene Delivery System

A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device

2009 ◽  
pp. 197-230
Author(s):  
Hiroto Hatakeyama ◽  
Hidetaka Akita ◽  
Kentaro Kogure ◽  
Hideyoshi Harashima
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Nonviral Gene Delivery ◽  
Gene Delivery System

scholarly journals Enhanced Transfection of Human Mesenchymal Stem Cells Using a Hyaluronic Acid/Calcium Phosphate Hybrid Gene Delivery System

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 798 ◽  
Author(s):  
Jung Eun Lee ◽  
Yue Yin ◽  
Su Yeon Lim ◽  
E. Seul Kim ◽  
Jaeback Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Human Mesenchymal Stem Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Gene Delivery System

Human mesenchymal stem cells (hMSCs) show enormous potential in regenerative medicine and tissue engineering. However, current use of hMSCs in clinics is still limited because there is no appropriate way to control their behavior in vivo, such as differentiation to a desired cell type. Genetic modification may provide an opportunity to control the cells in an active manner. One of the major hurdles for genetic manipulation of hMSCs is the lack of an efficient and safe gene delivery system. Herein, biocompatible calcium phosphate (CaP)-based nanoparticles stabilized with a catechol-derivatized hyaluronic acid (dopa-HA) conjugate were used as a carrier for gene transfection to hMSCs for improved differentiation. Owing to the specific interactions between HA and CD44 of bone marrow-derived hMSCs, dopa-HA/CaP showed significantly higher transfection in hMSCs than branched polyethylenimine (bPEI, MW 25 kDa) with no cytotoxicity. The co-delivery of a plasmid DNA encoding bone morphogenetic protein 2 (BMP-2 pDNA) and micro RNA 148b (miRNA-148b) by dopa-HA/CaP achieved significantly improved osteogenic differentiation of hMSCs.

A Review on Gene Delivery System of Layered Double Hydroxide

2013 ◽  
Vol 320 ◽  
pp. 533-539
Author(s):  
Li E Dong ◽  
Guo Jing Gou ◽  
Jie Huang ◽  
Yue Sun ◽  
Bing Xue
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Release Mechanism ◽  
Gene Delivery System ◽  
Dna Fragment ◽  
Double Hydroxide ◽  
Double Hydroxides ◽  
Dna Complex

This paper aims to provide a concise review on the study of a gene delivery system with layered double hydroxides (LDH) as carrier. The issues, such as preparation and cytobiology effect of LDH-DNA hybrids, and the release mechanism of DNA from LDH-DNA complex, were discussed in detail. For achieving a ideal cell transfection efficiency, it would be prospective to improve both the intercalation effect of giant DNA, such as plasmid DNA and long chain DNA fragments, and the gene transfection technique of small DNA fragment.

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