Transdermal Delivery of Poly-Hyaluronic Acid-Based Spherical Nucleic Acids for Chemogene Therapy

Nanoscale ◽  
2022 ◽  
Author(s):  
Kai Jiang ◽  
Di Zhao ◽  
Rui Ye ◽  
Xinlong Liu ◽  
Chao Gao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nucleic Acid ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Gene Delivery System ◽  
Transdermal Administration ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorders treatment. However, most of traditional SNA core materials are...

pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

2018 ◽  
Vol 54 (28) ◽  
pp. 3520-3523 ◽  
Author(s):  
Hui Li ◽  
Xiang Zhou ◽  
Dongbao Yao ◽  
Haojun Liang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug ◽  
Ph Responsive ◽  
Spherical Nucleic Acid ◽  
System P ◽  
Spherical Nucleic Acids

This study presents a class of pH-responsive spherical nucleic acids that can exactly image intracellular lysosomes and be an effective drug delivery system.

scholarly journals Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer

Gene ◽  
2012 ◽  
Vol 491 (2) ◽  
pp. 205-209 ◽  
Author(s):  
Tomoaki Kurosaki ◽  
Norihide Higuchi ◽  
Shigeru Kawakami ◽  
Yuriko Higuchi ◽  
Tadahiro Nakamura ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Gene Delivery ◽  
Delivery System ◽  
Molecular Targeting ◽  
Gene Delivery System

DNA nanoclew templated spherical nucleic acids for siRNA delivery

2018 ◽  
Vol 54 (29) ◽  
pp. 3609-3612 ◽  
Author(s):  
Weimin Ruan ◽  
Meng Zheng ◽  
Yang An ◽  
Yuanyuan Liu ◽  
David B. Lovejoy ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Sirna Delivery ◽  
Dna Nanostructure ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed DNA nanoclew (DC).

Reversible assembly-disassembly of plasmonic spherical nucleic acid enabling temperature-self-controllable and biomarker-activatable photothermal effect

2021 ◽  
Author(s):  
Lixian Huang ◽  
Jinling Zhang ◽  
Lifang Pang ◽  
Shengqiang Hu ◽  
Liangliang Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Melting Temperature ◽  
Self Assembly ◽  
The Self ◽  
Photothermal Effect ◽  
Spherical Nucleic Acid ◽  
Photothermal Heating ◽  
Spherical Nucleic Acids

Since the photothermal heating of plasmonic spherical nucleic acids (pSNAs) depended on the self-assembly level and melting temperature (Tm), temperature-self-controllable and biomarker-activatable photothermal effect in vivo was thus achieved using...

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

scholarly journals Enhanced Transfection of Human Mesenchymal Stem Cells Using a Hyaluronic Acid/Calcium Phosphate Hybrid Gene Delivery System

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 798 ◽  
Author(s):  
Jung Eun Lee ◽  
Yue Yin ◽  
Su Yeon Lim ◽  
E. Seul Kim ◽  
Jaeback Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Human Mesenchymal Stem Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Gene Delivery System

Human mesenchymal stem cells (hMSCs) show enormous potential in regenerative medicine and tissue engineering. However, current use of hMSCs in clinics is still limited because there is no appropriate way to control their behavior in vivo, such as differentiation to a desired cell type. Genetic modification may provide an opportunity to control the cells in an active manner. One of the major hurdles for genetic manipulation of hMSCs is the lack of an efficient and safe gene delivery system. Herein, biocompatible calcium phosphate (CaP)-based nanoparticles stabilized with a catechol-derivatized hyaluronic acid (dopa-HA) conjugate were used as a carrier for gene transfection to hMSCs for improved differentiation. Owing to the specific interactions between HA and CD44 of bone marrow-derived hMSCs, dopa-HA/CaP showed significantly higher transfection in hMSCs than branched polyethylenimine (bPEI, MW 25 kDa) with no cytotoxicity. The co-delivery of a plasmid DNA encoding bone morphogenetic protein 2 (BMP-2 pDNA) and micro RNA 148b (miRNA-148b) by dopa-HA/CaP achieved significantly improved osteogenic differentiation of hMSCs.

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

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