Solvent injection-lyophilization of tert-butyl alcohol/water cosolvent systems for the preparation of drug-loaded solid lipid nanoparticles

2010 ◽  
Vol 79 (1) ◽  
pp. 254-261 ◽  
Author(s):  
Ting Wang ◽  
Ning Wang ◽  
Yingying Zhang ◽  
Wancui Shen ◽  
Xingmei Gao ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Butyl Alcohol ◽  
Solvent Injection ◽  
Tert Butyl ◽  
Solid Lipid ◽  
Tert Butyl Alcohol ◽  
Alcohol Water

Diffusive dynamics of water in tert-butyl alcohol/water mixtures

2004 ◽  
Vol 120 (10) ◽  
pp. 4759-4767 ◽  
Author(s):  
Vania Calandrini ◽  
Antonio Deriu ◽  
Giuseppe Onori ◽  
Ruep E. Lechner ◽  
Jörg Pieper
Keyword(s):  
Butyl Alcohol ◽  
Tert Butyl ◽  
Tert Butyl Alcohol ◽  
Alcohol Water ◽  
Diffusive Dynamics

scholarly journals Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4781
Author(s):  
Van-An Duong ◽  
Thi-Thao-Linh Nguyen ◽  
Han-Joo Maeng
Keyword(s):  
Drug Delivery ◽  
Process Parameters ◽  
Solid Lipid Nanoparticles ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Solvent Injection ◽  
Injection Method ◽  
Solid Lipid ◽  
Injection Process

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

Coefficients B de viscosité dans les systèmes ternaires aqueux. III. Halogénures alcalins–alcool tert-butylique–eau à 25 °C

1979 ◽  
Vol 57 (24) ◽  
pp. 3247-3252 ◽  
Author(s):  
Marc Palma ◽  
Jean-Pierre Morel
Keyword(s):  
Linear Relationship ◽  
Structural Properties ◽  
Organic Solvents ◽  
Linear Correlation ◽  
Butyl Alcohol ◽  
Tert Butyl ◽  
Tert Butyl Alcohol ◽  
Alcohol Water ◽  
Coefficient Of Viscosity

We have measured the coefficient of viscosity B at 25 °C of HCl, LiCl, NaCl, KCl, RbCl, KI, and KBr in the mixtures of aqueous organic solvents containing from 10 to 40% tert-butyl alcohol by weight (X), the concentration of electrolyte varying from 0.1 to 0.3 M.Plots of B = f (x) show points of inflexion and minima whose positions can be explained by the structural properties of the mixed solvent.In water, a linear relationship between the entropy of hydration and coefficient B of the ions is observed. In the same way, it can be shown that a linear correlation exists between the entropy of solvation and coefficient B of the electrolytes for all the mixtures studied.These correlations lead to the characterization of two distinct zones (X < 20% and X > 20%) for the range of tert-butyl alcohol–water mixtures. [Journal translation]

Pressure effect on water dynamics in tert-butyl alcohol/water solutions

2006 ◽  
Vol 18 (36) ◽  
pp. S2363-S2371 ◽  
Author(s):  
Vania Calandrini ◽  
Antonio Deriu ◽  
Giuseppe Onori ◽  
Alessandro Paciaroni ◽  
Mark T F Telling
Keyword(s):  
Pressure Effect ◽  
Butyl Alcohol ◽  
Water Dynamics ◽  
Water Solutions ◽  
Tert Butyl ◽  
Tert Butyl Alcohol ◽  
Alcohol Water

Formation of Zinc–Peptide Spherical Microparticles During Lyophilization from tert-Butyl Alcohol/Water Co-solvent System

2008 ◽  
Vol 25 (12) ◽  
pp. 2799-2806 ◽  
Author(s):  
Feng Qian ◽  
Nina Ni ◽  
Jia-Wen Chen ◽  
Sridhar Desikan ◽  
Vijay Naringrekar ◽  
...  
Keyword(s):  
Solvent System ◽  
Butyl Alcohol ◽  
Tert Butyl ◽  
Tert Butyl Alcohol ◽  
Alcohol Water ◽  
Spherical Microparticles
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