scholarly journals Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4781
Author(s):  
Van-An Duong ◽  
Thi-Thao-Linh Nguyen ◽  
Han-Joo Maeng
Keyword(s):  
Drug Delivery ◽  
Process Parameters ◽  
Solid Lipid Nanoparticles ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Solvent Injection ◽  
Injection Method ◽  
Solid Lipid ◽  
Injection Process

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

scholarly journals Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Smart Drug Delivery Systems in the Treatment of Glioblastoma Multiforme

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 860
Author(s):  
Raneem Jnaidi ◽  
António José Almeida ◽  
Lídia M. Gonçalves
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Tumor Location ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Solid Lipid

Glioblastoma multiforme (GBM) is the most common and malignant type of brain tumor. In fact, tumor recurrence usually appears a few months after surgical resection and chemotherapy, mainly due to many factors that make GBM treatment a real challenge, such as tumor location, heterogeneity, presence of the blood-brain barrier (BBB), and others. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) represent the most promising carriers for therapeutics delivery into the central nervous system (CNS) owing to their inherent ability to cross the BBB. In this review, we present the main challenges in GBM treatment, a description of SLNs and NLCs and their valuable role as drug carriers in GBM treatment, and finally, a detailed description of all modification strategies that aim to change composition of SLNs and NLCs to enhance treatment outcomes. This includes modification of SLNs and NLCs to improve crossing the BBB, reduced GBM cell resistance, target GBM cells selectively minimizing side effects, and modification strategies to enhance SLNs and NLCs nose-to-brain delivery. Finally, future perspectives on their use are also be discussed, to provide insight about all strategies with SLNs and NLCs formulation that could result in drug delivery systems for GBM treatment with highly effective theraputic and minimum undesirable effects.

Challenges in oral drug delivery and applications of lipid nanoparticles as potent oral drug carriers for managing cardiovascular risk factors

2020 ◽  
Vol 21 ◽  
Author(s):  
Neslihan Üstündağ Okur ◽  
Panoraia I. Siafaka ◽  
Evren Homan Gökçe
Keyword(s):  
Drug Delivery ◽  
Cardiovascular Risk ◽  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Oral Drug ◽  
Solid Lipid

Background: The oral application of drugs is the most popular route through which the systemic effect can be achieved. Nevertheless, oral administration is limited by difficulties related to physicochemical properties of the drug molecule, including low aqueous solubility, instability, low permeability, and rapid metabolism, all of which result in low and irregular oral bioavailability. Objective: The enhancement of oral bioavailability of drug molecules with such properties could lead to extreme complications in drug preparations. Oral lipid based nanoparticles seems to possess extensive advantages due to their ability to increase the solubility, simplifying intestinal absorption and decrease or eradicate the effect of food on the absorption of low soluble, lipophilic drugs and therefore improving the oral bioavailability. Method: The present review provides a summary of the general theory of lipid based nanoparticles, their preparation methods as well as their oral applications. Moreover, the oral drug delivery challenges are discussed. Results: According to this review, the most frequent types of lipid-based nanoparticle, the solid lipid nanoparticles and nanostructured lipid carriers are potent oral carriers due to their ability to penetrate the oral drug adsorption barriers. Moreover, such lipid nanoparticles can be beneficial drug carriers against cardiovascular risk disorders as diabetes, hypertension etc. Conclusion: In this review, the most current and promising studies involving Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as oral drug carriers are reported aiming to assist researchers who focus their research on lipid based nanoparticles.

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: A Review of the Effect of Physicochemical Formulation Factors in the Optimization Process, Different Preparation Technique, Characterization, and Toxicity

2019 ◽  
Vol >15 (5) ◽  
pp. 436-453
Author(s):  
Ganesan Poovi ◽  
Thangavel Mahalingam Vijayakumar ◽  
Narayanasamy Damodharan
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Nanostructured Lipid Carriers ◽  
Pharmacokinetic Studies ◽  
Preparation Technique ◽  
Solid Lipid ◽  
Research Findings ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Background:The high molecular weight and increasing lipophilicity drug face many problems starting from the drug development to formulation and conduction of pharmacological, toxicological and pharmacokinetic studies to its biological application. To overcome this problem, a different formulation of nano-sized drugs was developed recently. The use of Solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs) offers new insight into the formulation of the poorly soluble drug.Objective:The study aimed to investigate the literature with regard to the development of SLNs and NLCs for lipid-based nano drug delivery of poorly soluble drugs, with a view to identifying the factors influencing the optimization of the formulation of SLNs and NLCs and strategies to decrease the use of organic solvent during the preparation.Results:This review highlights the simple and easily scaled-up novel lipid nanoparticles (SLNs and NLCs) and their factors to be considered in the formulation for the proper selection of excipients. Also, this review summarizes the research findings reported by the different researchers regarding the principle formulation components, different preparation techniques, characterization, and toxicology of lipid nanoparticles.Conclusion:The SLNs/NLCs make this drug delivery system as one of the promising delivery systems, and safe colloidal lipid carriers for the delivery of poorly soluble drug and will be a solution to the formulation scientist for the solubility and permeability problem associated with the drugs to assure its good bioavailability.

Recent Advances in Nanotechnology based Tubercular Chemotherapy

2015 ◽  
Vol 8 (3) ◽  
pp. 2979-2994
Author(s):  
Harish Dureja ◽  
Sunil Khatak
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Carriers ◽  
Lipid Nanoparticles ◽  
Effective Drug ◽  
Prolonged Treatment ◽  
Multi Drug Resistance ◽  
Second Line ◽  
Drug Bioavailability ◽  
Solid Lipid

Tuberculosis (TB) is a more prevalent granulomatos bacterial infection, which remains the world’s second most common cause of death due to infections of Mycobacterium tuberculosis (M.Tuberculosis). A number of characteristics of mycobacterium makes there disease chronic and necessitate prolonged treatment. The emergence of multi-drug-resistance (MDR) stains of M.Tuberculosis makes its necessary for the development of effective combinations of either first-line or second-line drugs or discovery of new safe and effective drug molecules and also implements other modalities of treatment. A number of novel carrier-based drug delivery systems incorporating the traditional and newer anti-tubercular agents have been shown incredible promise to target the site of action, reduce dosing frequency and enhance drug bioavailability with the objective of improving patient compliance. Nanoparticulate system have unique and comparatively more effective drug delivery carriers, including liposomal-mediated drug delivery, polymeric nanoparticles/microparticles, solid lipid nanoparticles, nanosuspensions, nanoemulsions, niosomes, dendrimers, Metal/cyclodextrin inclusion complexes and other nanosystems exploiting the extraordinary properties of matter at the nanoscale. Nanoparticles shown significant improvements in diagnosis, treatment and prevention and provide the flexibility of selecting the invasive and non-invasive route of delivery for chemotherapy of tuberculosis. This manuscript have been made to highlight and overviews the present WHO estimated burden of tuberculosis globally, recent discovery of safe and effective newer anti-tubercular drug moleculesfor MDR and XDR tuberculosis, first and second line anti-tubercular drugs loaded novel nanoparticle carriers for chemotherapy and development of solid lipid nanoparticles as an alternative drug carriers for tubercular chemotherapy.  

Nanotechnological Advances for Cutaneous Release of Tretinoin: An Approach to Minimize Side Effects and Improve Therapeutic Efficacy

2018 ◽  
Vol 25 (31) ◽  
pp. 3703-3718 ◽  
Author(s):  
Ana Claudia Pompeu Raminelli ◽  
Valeria Romero ◽  
Mohammad H. Semreen ◽  
Gislaine Ricci Leonardi
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Patient Compliance ◽  
Solid Lipid Nanoparticles ◽  
Pharmaceutical Preparations ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Nanostructured Polymers ◽  
Solid Lipid

Background: The clinical efficacy of the topical tretinoin is widely studied and has been well established for many therapeutic interventions, among some, photoaging, acne, and melasma. However, the side effects, mainly cutaneous irritation, erythema, xerosis and peeling, remain major obstacle to the patient compliance. Besides, the insight regarding the drug delivery profile is essential to understand the therapeutic action of the drug. Methods: Through bibliographic research in databases we highlight further advances and an update on tretinoin delivery systems such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrins, nanostructured polymers and other technological systems that reduce its side effects and improve the permeation profile to potentiate efficacy and drug safety on the skin. Results: Pharmaceutical preparations were developed and evaluated for permeability in in vitro models using pig ear, snake, mouse and human skin, and potential for irritation was also verified using release systems for tretinoin and compared to available commercial formulations. Overall results indicated the composition, charge and size of the system influences the tretinoin delivery, modulating the type of release and its retention. Small unilamellar vesicles promoted greater cutaneous delivery of tretinoin. Negative charge, for both liposomes and niosomes, can improve pig skin hydration as well as the tretinoin retention. The quantity of solid lipids and the type of oil used in the composition of solid lipid nanoparticles and nanostructured lipid carriers affected percutaneous drug delivery. Conclusion: As evident from the literature, the tretinoin technological delivery systems consist an innovative and potential management for increasing the patient compliance presenting safety and efficacy.

scholarly journals Preparation, Characterization and Evaluation of Elvitegravir-Loaded Solid Lipid Nanoparticles for Enhanced Solubility and Dissolution Rate

2015 ◽  
Vol 14 (9) ◽  
pp. 1549-1556
Author(s):  
P Kommavarapu ◽  
A Maruthapillai ◽  
K Palanisamy
Keyword(s):  
Particle Size ◽  
Dissolution Rate ◽  
Solid Lipid Nanoparticles ◽  
Entrapment Efficiency ◽  
Aqueous Solubility ◽  
Lipid Nanoparticles ◽  
Solvent Injection ◽  
Injection Method ◽  
Solid Lipid ◽  
Enhanced Solubility

Purpose: To enhance the aqueous solubility and dissolution rate of elvitegravir (EVG) by formulating the drug as solid lipid nanoparticles (SLNs) using solvent injection method.Methods: EVG-loaded SLNs were prepared by solvent injection method. Four different formulations of SLN were prepared using gelucire - 44/14 as lipid core in ethanol, soya lecithin as emulsifier, and polysorbate 80 as surfactant in the aqueous phase. The SLNs were characterized for various physical properties, including particle size, zeta potential, polydispersity, release profile and entrapment efficiency.Results: The yield of SLNs was in the range 151.0 ± 2.4 to 199.1 ± 2.7 nm. Significant changes were observed in mean particle size (nm), Z - potential (mV) and polydispersity index (PDI) of the SLNs by varying the  concentration of cryoprotectant. EVG – SLNs demonstrated a 800 – 1030-fold enhancement in aqueous solubility compared with plain EVG. The dissolution efficiency (DE) for SLNs was > 63 % in all cases and increased up to 83 % with increasing lipid load.Conclusion: Successful preparation and characterization of elvitegravir–loaded solid lipid nanoparticles by solvent injection method has been accomplished in this study.Keywords: Elvitegravir, Solid lipid nanoparticles, Cryoprotectant, Lipid load, Entrapment efficiency

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