Anticancer activity of Moringa oleifera mediated silver nanoparticles on human cervical carcinoma cells by apoptosis induction

2014 ◽  
Vol 117 ◽  
pp. 354-359 ◽  
Author(s):  
Karunamoorthy Vasanth ◽  
Kaliappan Ilango ◽  
Ramasamy MohanKumar ◽  
Aruna Agrawal ◽  
Govind Prasad Dubey
Keyword(s):  
Silver Nanoparticles ◽  
Anticancer Activity ◽  
Cervical Carcinoma ◽  
Moringa Oleifera ◽  
Carcinoma Cells ◽  
Apoptosis Induction ◽  
Human Cervical Carcinoma ◽  
Human Cervical Carcinoma Cells

scholarly journals Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells

2020 ◽  
Author(s):  
Hong Zhang ◽  
Yuhong Chen ◽  
Cuixia Di ◽  
Caipeng Xu ◽  
Xiaohua Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Binding Protein ◽  
Carcinoma Cells ◽  
Splicing Factor ◽  
Dependent Manner ◽  
Apoptosis Induction ◽  
Human Cervical Carcinoma ◽  
Cycle Arrest ◽  
Human Cervical Carcinoma Cells

Abstract Background Splicing factor poly(rC)-binding protein 1 (PCBP1) is a novel tumor suppressor that is downregulated in many cancers thereby regulates tumor formation and metastasis. However, to date, little information has been available on the molecular mechanisms by which PCBP1 evokes apoptosis.Results Here, we explored the molecular mechanism by which PCBP1 triggers apoptosis in human cervical cancer cells. We testified that overexpression of PCBP1 greatly repressed proliferation of HeLa cells in time-dependent manner. It also induced a significant increase in G2 / M phase arrest and apoptosis. Furthermore, it was shown that overexpression of PCBP1 caused p73 splicing, and thus efficiently downregulated the ratio of Bax / Bcl-2, the release of cytochrome c and the expression of caspase-3.Conclusion Our results revealed that PCBP1 played a vital role in cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells and targeting PCBP1 may be a promising approach in cervical cancer therapy.

Nevirapine induces growth arrest and premature senescence in human cervical carcinoma cells

2008 ◽  
Vol 111 (2) ◽  
pp. 344-349 ◽  
Author(s):  
Konstantinos Stefanidis ◽  
Dimitris Loutradis ◽  
Leandros-Vassilios Vassiliou ◽  
Vasiliki Anastasiadou ◽  
Erasmia Kiapekou ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Growth Arrest ◽  
Carcinoma Cells ◽  
Premature Senescence ◽  
Human Cervical Carcinoma ◽  
Human Cervical Carcinoma Cells

Antiproliferative and Apoptotic Effects of Iron Chelators on Human Cervical Carcinoma Cells

2002 ◽  
Vol 85 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Thierry Simonart ◽  
Johan R. Boelaert ◽  
Roger Mosselmans ◽  
Graciela Andrei ◽  
Jean-Christophe Noel ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Iron Chelators ◽  
Human Cervical Carcinoma ◽  
Apoptotic Effects ◽  
Human Cervical Carcinoma Cells

Anticancer Properties of Extracts from Opuntia humifusa Against Human Cervical Carcinoma Cells

2015 ◽  
Vol 18 (1) ◽  
pp. 31-44 ◽  
Author(s):  
Sahng-Wook Hahm ◽  
Jieun Park ◽  
Se-Yeong Oh ◽  
Chul-Won Lee ◽  
Kun-Young Park ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Anticancer Properties ◽  
Human Cervical Carcinoma ◽  
Opuntia Humifusa ◽  
Human Cervical Carcinoma Cells
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