An in-vitro study of enzyme-responsive Prussian blue nanoparticles for combined tumor chemotherapy and photothermal therapy

2015 ◽  
Vol 125 ◽  
pp. 277-283 ◽  
Author(s):  
Peng Xue ◽  
Karis K.Y. Cheong ◽  
Yafeng Wu ◽  
Yuejun Kang
2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Quan Tao ◽  
Genghan He ◽  
Sheng Ye ◽  
Di Zhang ◽  
Zhide Zhang ◽  
...  

Abstract Background Combining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy. Results In this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor. Conclusions Overall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment. Graphical Abstract


2017 ◽  
Vol 12 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Samira Rasouli Koohi ◽  
Mohammad Ali Derakhshan ◽  
Faramarz Faridani ◽  
Samad Muhammad Nejad ◽  
Saeid Amanpour ◽  
...  

2017 ◽  
Vol 17 ◽  
pp. 56-60 ◽  
Author(s):  
Leili Beytollahi ◽  
Maryam Pourhajibagher ◽  
Nasim Chiniforush ◽  
Roghayeh Ghorbanzadeh ◽  
Reza Raoofian ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document