Improved antitumor efficacy and reduced toxicity of docetaxel using anacardic acid functionalized stealth liposomes

2018 ◽  
Vol 172 ◽  
pp. 213-223 ◽  
Author(s):  
Varun Kushwah ◽  
Devesh Kumar Jain ◽  
Ashish Kumar Agrawal ◽  
Sanyog Jain
Keyword(s):  
Anacardic Acid ◽  
Antitumor Efficacy ◽  
Stealth Liposomes ◽  
Reduced Toxicity

scholarly journals Enhanced antitumor efficacy and reduced toxicity of Abnormal Savda Munziq on tumor bearing mice treated with chemotherapy

Oncotarget ◽  
2017 ◽  
Vol 8 (54) ◽  
pp. 92682-92698
Author(s):  
Tao Yang ◽  
Wenhui Shi ◽  
Zukereguli Wumaierniyazi ◽  
Lianlian Shan ◽  
Weiwei Miao ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Tumor Bearing ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq ◽  
Reduced Toxicity

scholarly journals Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic

2021 ◽  
Vol 118 (26) ◽  
pp. e2025930118
Author(s):  
Iñaki Etxeberria ◽  
Elixabet Bolaños ◽  
Alvaro Teijeira ◽  
Saray Garasa ◽  
Alba Yanguas ◽  
...  
Keyword(s):  
Maximum Tolerated Dose ◽  
Adoptive T Cell Therapy ◽  
Antitumor Efficacy ◽  
Liver Inflammation ◽  
Antigen Binding Site ◽  
Antitumor Effects ◽  
T Cell Therapy ◽  
Preferential Cleavage ◽  
Regional Lymphadenectomy ◽  
Reduced Toxicity

Costimulation via CD137 (4-1BB) enhances antitumor immunity mediated by cytotoxic T lymphocytes. Anti-CD137 agonist antibodies elicit mild liver inflammation in mice, and the maximum tolerated dose of Urelumab, an anti-human CD137 agonist monoclonal antibody, in the clinic was defined by liver inflammation–related side effects. A protease-activated prodrug form of the anti-mouse CD137 agonist antibody 1D8 (1D8 Probody therapeutic, Pb-Tx) was constructed and found to be selectively activated in the tumor microenvironment. This construct, which encompasses a protease-cleavable linker holding in place a peptide that masks the antigen binding site, exerted antitumor effects comparable to the unmodified antibody but did not result in liver inflammation. Moreover, it efficaciously synergized with both PD-1 blockade and adoptive T-cell therapy. Surprisingly, minimal active Pb-Tx reached tumor-draining lymph nodes, and regional lymphadenectomy did not abrogate antitumor efficacy. By contrast, S1P receptor–dependent recirculation of T cells was absolutely required for efficacy. The preferential cleavage of the anti-CD137 Pb-Tx by tumor proteases offers multiple therapeutic opportunities, including neoadjuvant therapy, as shown by experiments in which the Pb-Tx is given prior to surgery to avoid spontaneous metastases.

Enhanced Antitumor Efficacy and Reduced Toxicity of Docetaxel Loaded Estradiol Functionalized Stealth Polymeric Nanoparticles

2015 ◽  
Vol 12 (11) ◽  
pp. 3871-3884 ◽  
Author(s):  
Sanyog Jain ◽  
Gollapalli Spandana ◽  
Ashish Kumar Agrawal ◽  
Varun Kushwah ◽  
Kaushik Thanki
Keyword(s):  
Polymeric Nanoparticles ◽  
Antitumor Efficacy ◽  
Reduced Toxicity

Improved antitumor efficacy and reduced toxicity of liposomes containing bufadienolides

2011 ◽  
Vol 34 (9) ◽  
pp. 1487-1494 ◽  
Author(s):  
Kaili Hu ◽  
Lin Zhu ◽  
Haiyuan Liang ◽  
Fuqiang Hu ◽  
Jianfang Feng
Keyword(s):  
Antitumor Efficacy ◽  
Reduced Toxicity

scholarly journals S318 Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP

2021 ◽  
Vol 116 (1) ◽  
pp. S138-S138
Author(s):  
Yunus Emre Demirhan ◽  
Praveen Rajendran ◽  
Wan-Mohaiza Dashwood ◽  
Sabeeta Kapoor ◽  
Ahmet Ulusan ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Preclinical Model ◽  
Reduced Toxicity

Cytotoxicity, NF-κB P65 inhibition, and in vivo antitumor efficacy of sesquiterpene lactones from Piptocoma rufescens

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Ren ◽  
U Muñoz Acuña ◽  
DD Lantvit ◽  
F Jiménez ◽  
R García ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Antitumor Efficacy
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