scholarly journals Enhanced antitumor efficacy and reduced toxicity of Abnormal Savda Munziq on tumor bearing mice treated with chemotherapy

Oncotarget ◽  
2017 ◽  
Vol 8 (54) ◽  
pp. 92682-92698
Author(s):  
Tao Yang ◽  
Wenhui Shi ◽  
Zukereguli Wumaierniyazi ◽  
Lianlian Shan ◽  
Weiwei Miao ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Tumor Bearing ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq ◽  
Reduced Toxicity

scholarly journals A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, andIn VivoAntitumor Efficacy and Safety

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Wang ◽  
Ke-Chun Wu ◽  
Bing-Xiang Zhao ◽  
Xin Zhao ◽  
Xin Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Therapeutic Efficacy ◽  
Antitumor Efficacy ◽  
Allergic Reactions ◽  
Cremophor El ◽  
Efficacy And Safety ◽  
Tumor Bearing ◽  
Allergic Effect ◽  
Injection Product

The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL. The pharmacokinetics, biodistribution,in vivoantitumor activity and safety of PTX microemulsion was evaluated. The results of pharmacokinetic and distribution properties of PTX in the microemulsion were similar to those of the PTX injection. The antitumor efficacy of the PTX microemulsion in OVCRA-3 and A 549 tumor-bearing animals was similar to that of PTX injection. The PTX microemulsion did not cause haemolysis, erythrocyte agglutination or simulative reaction. The incidence and degree of allergic reactions exhibited by the PTX microemulsion group, with or without premedication, were significantly lower than those in the PTX injection group (P<.01). In conclusion, the PTX microemulsion had similar pharmacokinetics and anti-tumor efficacy to the PTX injection, but a significantly reduced allergic effect due to CrEL, indicating that the PTX microemulsion overcomes the disadvantages of the conventional PTX injection and is one way of avoiding the limitations of current injection product while providing suitable therapeutic efficacy.

Investigations into cytotoxic effects of the herbal preparation Abnormal Savda Munziq

2015 ◽  
Author(s):  
Harald Kühnel ◽  
Abulimiti Adilijiang ◽  
Agnes Dadak ◽  
Matthias Wieser ◽  
Halmurat Upur ◽  
...  
Keyword(s):  
Herbal Preparation ◽  
Cytotoxic Effects ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq

scholarly journals Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 880-887 ◽  
Author(s):  
Haowen Li ◽  
Yijing Li ◽  
Hui Ao ◽  
Dongdong Bi ◽  
Meihua Han ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Annonaceous Acetogenins ◽  
Tumor Bearing ◽  
Folate Targeting

scholarly journals Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Halmurat Upur ◽  
Abdiryim Yusup ◽  
Isabelle Baudrimont ◽  
Anwar Umar ◽  
Benedicte Berke ◽  
...  
Keyword(s):  
Rna Synthesis ◽  
Ethanol Extract ◽  
Cellular Protein ◽  
Time Dependent ◽  
Dependent Manner ◽  
Human Hepatoma ◽  
Dna And Rna ◽  
Dna And Rna Synthesis ◽  
Abnormal Savda ◽  
Abnormal Savda Munziq

Abnormal Savda Munziq (ASMq) is a traditional Uighur medicinal herbal preparation, commonly used for the treatment and prevention of cancer. We tested the effects of ethanol extract of ASMq on cultured human hepatoma cells (HepG2) to explore the mechanism of its putative anticancer properties, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) bromide, neutral red and lactate dehydrogenase (LDH) leakage assays, testing the incorporation of3[H]-leucine and3[H]-nucleosides into protein, DNA and RNA, and quantifying the formation of malondialdehyde-thiobarbituric acid (MDA) adducts. ASMq ethanol extract significantly inhibited the growth of HepG2 and cell viability, increased the leakage of LDH after 48 hours or 72 hours treatment, in a concentration- and time-dependent manner (P< .05). Cellular protein, DNA and RNA synthesis were inhibited in a concentration- and time-dependent manner (P< .05). No significant MDA release in culture medium and no lipid peroxidation in cells were observed. The results suggest that the cytotoxic effects of ASMq ethanol extract might be related to inhibition of cancer cell growth, alteration of cell membrane integrity and inhibition of cellular protein, DNA and RNA synthesis.

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