Calcium phosphate-polymeric nanoparticle system for co-delivery of microRNA-21 inhibitor and doxorubicin

Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions

Download Full-text

Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury

Journal of Controlled Release ◽

10.1016/j.jconrel.2013.11.001 ◽

2014 ◽

Vol 174 ◽

pp. 15-26 ◽

Cited By ~ 51

Author(s):

Simonetta Papa ◽

Raffaele Ferrari ◽

Massimiliano De Paola ◽

Filippo Rossi ◽

Alessandro Mariani ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Activated Microglia ◽

Polymeric Nanoparticle ◽

Cord Injury ◽

Nanoparticle System

Download Full-text

Formulation and Optimization of Eudragit RS PO-Tenofovir Nanocarriers Using Box-Behnken Experimental Design

Journal of Nanomaterials ◽

10.1155/2015/630690 ◽

2015 ◽

Vol 2015 ◽

pp. 1-11 ◽

Cited By ~ 6

Author(s):

Kefilwe Matlhola ◽

Lebogang Katata-Seru ◽

Lesego Tshweu ◽

Indra Bahadur ◽

Gertrude Makgatho ◽

...

Keyword(s):

Particle Size ◽

Zeta Potential ◽

Noncovalent Interactions ◽

Eudragit Rs ◽

Polymeric Nanoparticle ◽

Nanoprecipitation Method ◽

Nanoparticle System ◽

Polymer Surfactant ◽

Eudragit Rs Po

The objective of present study was to develop an optimized polymeric nanoparticle system for the antiretroviral drug tenofovir. A modified nanoprecipitation method was used to prepare Eudragit RS PO nanoparticles of the drug. The effect of amount of polymer, surfactant concentration, and sonication time on particle size, particle distribution, encapsulation efficiency (EE), and zeta potential were assessed and optimized utilizing a three-factor, three-level Box-Behnken Design (BBD) of experiment. Fifteen formulations of nanoparticles were prepared as per BBD and evaluated for particle size, polydispersity index (PDI), EE, and zeta potential. The results showed that the measured mean particle sizes were in the range of 233 to 499 nm, PDI ranged from 0.094 to 0.153, average zeta potential ranged from −19.9 to −45.8 mV, and EE ranged between 98 and 99%. The optimized formulation was characterized forin vitrodrug release and structural characterization. The mean particle size of this formulation was 233 nm with a PDI of 0.0107. It had a high EE of 98% and average zeta potential of −35 mV, an indication of particle stability. The FTIR showed some noncovalent interactions between the drug and polymer but a sustained release was observedin vitrofor up to 80 hours.

Download Full-text

NANOPARTICLE AS THE STRATEGY FOR THE DEVELOPMENT OF SARS-COV-2 ANTIVIRAL DRUGS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2021v13i5.42604 ◽

2021 ◽

pp. 33-43

Author(s):

SRI HARTATI YULIANI

Keyword(s):

Antiviral Drug ◽

Drug Repurposing ◽

Antiviral Drugs ◽

Nanostructured Lipid Carrier ◽

Solid Lipid Nanoparticle ◽

Metallic Nanoparticle ◽

Drug Candidates ◽

Polymeric Nanoparticle ◽

Nanoparticle System ◽

Selection Of

In just a matter of months, SARS-CoV-2 had spread around the world. Scientists collaborate to solve the problem. The development of antiviral drugs is a challenge in itself due to the rapidly changing nature of the virus. Selection of drug candidates can be done quickly through the repurposing drug method. Broad-spectrum antiviral drugs may be strong candidates for SARS-CoV-2 therapy. Nanotechnology is one solution in the development of antiviral drug delivery systems. The advantages possessed by the nanoparticle system can answer the need for an ideal antiviral drug. This article will focus on the development of nanoparticle preparations as a strategy in handling viruses, including SARS-CoV-2. The selection of article for the current review was searched from specialized databases such as Elsevier, Pubmed, Science Direct, Medscape and other credible databases using the keywords nanoparticle, SARS-CoV-2, Covid-19, drug repurposing, polymeric nanoparticle, micelle, liposome, solid lipid nanoparticle, nanostructured lipid carrier, dendrimer, metallic nanoparticle. The range of articles was 2007–2021.

Download Full-text

Controlled Release of Ibuprofen from Polymeric Nanoparticles

10.26434/chemrxiv.9884114.v1 ◽

2019 ◽

Author(s):

Sara Shehata ◽

Christopher Serpell ◽

Stefano Biagini

Keyword(s):

Self Assembly ◽

Polymeric Nanoparticles ◽

Controlled Delivery ◽

Therapeutic Drug ◽

Triggered Release ◽

Polymeric Systems ◽

Polymeric Nanoparticle ◽

Alkaline Conditions ◽

Nanoparticle System ◽

Poly Ethylene

Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions

Download Full-text