A Prospective, Randomized Controlled Pre-Clinical Trial to Evaluate Different Formulations of Biphasic Calcium Phosphate with an Hydroxyapatite Collagen Membrane

2012 ◽  
pp. 121029075332002
Author(s):  
Myron Nevins ◽  
Marc L. Nevins ◽  
Schupbach Peter ◽  
Soo-Woo Kim ◽  
Zhao Lin ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Collagen Membrane ◽  
Randomized Controlled

scholarly journals Comparative Evaluation of Clinical and Radiological Parameters Following the Use of Biphasic Alloplastic Material With Amniotic Membrane/ Collagen Membrane for the Management of Periodontal Intra-bony Defects – a Prospective Double Blinded Randomised Controlled Clinical Trial

2021 ◽  
Author(s):  
Nivedha Venkatesan ◽  
Vamsi Lavu ◽  
S.K Balaji
Keyword(s):  
Clinical Trial ◽  
Calcium Phosphate ◽  
Amniotic Membrane ◽  
Biphasic Calcium Phosphate ◽  
Statistical Significance ◽  
Collagen Membrane ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Barrier Membrane

Abstract Background: The concept of periodontal regeneration has been revolutionised since the introduction of growth factors and bioactive bone substitutes which ensures optimal regeneration of the diseased periodontium. The aim of the present study was to evaluate the efficacy of Amniotic membrane + Biphasic Calcium phosphate as compared to Collagen membrane + Biphasic Calcium phosphate for the management of periodontal intrabony defectsMethods: 50 systemically healthy patients with localised moderate to severe periodontitis, sites which had a Probing Pocket Depth (PPD) ≥6 mm and an intrabony component of ≥3 mm as detected on Intra oral periapical radiographs (IOPAR) and bone sounding were recruited based on specific inclusion and exclusion criteria. They were randomly allocated by computer generated tables to CM+BiCP and AM+BiCP groups. The amount of bone fill and changes in Probing Pocket Depth, Clinical Attachment Level were measured at baseline and six months.Results: The results of the present study showed a mean reduction in the PPD of 2.89±.69 mm in the CM+BiCP group and 2.95±.57 mm in the AM+BiCP group and CAL gain of 2.60±1.43 mm in CM+BiCP group 3.18±1.13 mm in the AM+BiCP group at 6 months follow-up with no statistical significance between the groups. In terms of Defect resolution, 98.62 ± 6.51 % was achieved in CM +BiCP group and 98.25 ± 7.21 % in AM +BiCP group. Conclusion: Within the limitations of the present study, it can be concluded that AM can be used as a barrier membrane, in conjunction with Biphasic calcium phosphate, and provides comparable results to Collagen membrane with Biphasic calcium phosphate when used in the management of periodontal intrabony defects. Trail registration: The study protocol was approved by the Institutional Ethics Committee of Sri Ramachandra Institute of Higher Education and Research (IEC/18/DEC/145/51) and was registered in the Clinical Trial Registry of India [Ref No: CTRI/2020/03/0240075].

A Prospective, Randomized Controlled Preclinical Trial to Evaluate Different Formulations of Biphasic Calcium Phosphate in Combination With a Hydroxyapatite Collagen Membrane to Reconstruct Deficient Alveolar Ridges

2013 ◽  
Vol 39 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Myron Nevins ◽  
Marc L. Nevins ◽  
Peter Schupbach ◽  
Soo-Woo Kim ◽  
Zhao Lin ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Osteogenic Potential ◽  
Collagen Membrane ◽  
Intimate Contact ◽  
Preclinical Trial ◽  
Native Bone ◽  
Randomized Controlled ◽  
Study Results

Many patients and clinicians would prefer a synthetic particulate bone replacement graft, but most available alloplastic biomaterials have limited osteogenic potential. An alloplast with increased regenerative capacity would be advantageous for the treatment of localized alveolar ridge defects. This prospective, randomized controlled preclinical trial utilized 6 female foxhounds to analyze the osteogenic impact of different formulations of biphasic calcium phosphate (BCP) in combination with an hydroxyapatite-collagen membrane and their ability to reconstruct deficient alveolar ridges for future implant placement. The grafted sites were allowed to heal 3 months, and then trephine biopsies were obtained to perform light microscopic and histomorphometric analyses. All treated sites healed well with no early membrane exposure or adverse soft tissue responses during the healing period. The grafted sites exhibited greater radiopacity than the surrounding native bone with BCP particles seen as radiopaque granules. The graft particles appeared to be well-integrated and no areas of loose particles were observed. Histologic evaluation demonstrated BCP particles embedded in woven bone with dense connective tissue/marrow space. New bone growth was observed around the graft particles as well as within the structure of the graft particulate. There was intimate contact between the graft particles and newly formed bone, and graft particles were bridged by the newly formed bone in all biopsies from the tested groups. The present study results support the potential of these BCP graft particulates to stimulate new bone formation. Clinical studies are recommended to confirm these preclinical findings.

Macro/Microporous Biphasic Calcium Phosphate Cylinders and Resorbable Collagen Membranes for Guided Bone Growth

2007 ◽  
Vol 361-363 ◽  
pp. 439-442
Author(s):  
Borhane H. Fellah ◽  
Said Kimakhe ◽  
G. Daculsi ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Collagen Membrane ◽  
Calcium Phosphate Ceramic ◽  
Collagen Membranes ◽  
Large Bone ◽  
Empty Control ◽  
Large Bone Defects

This study aims at evaluating bone growth in critical-sized femoral defects of rats filled with macro micro porous biphasic calcium phosphate ceramic (MBCP) cylinders surrounded or not by a resorbable collagen membrane. Femoral defects left empty (control) exhibited partial bone ingrowths after 3 and 6 weeks and were completely healed at 12 weeks. The defects filled with the collagen membranes appeared partially healed suggesting that the membranes constraint bone ingrowth. Bone formation occurred around the collagen membrane which partially degraded over time. In the MBCP/membrane group, bone has grown inside the macro pores of the MBCP cylinders. Bone ingrowth was more rapid and abundant in the defects filled with MBCP alone. The combination MBCP/collagen membrane may be beneficial for the reconstruction of large bone defects without using repetitive surgeries and autologous bone grafting.

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