scholarly journals Morphology and properties of thermal/cooling-gel bi-phasic systems based on hydroxypropyl methylcellulose and hydroxypropyl starch

2016 ◽  
Vol 101 ◽  
pp. 46-52 ◽  
Author(s):  
Yanfei Wang ◽  
Long Yu ◽  
Fengwei Xie ◽  
Liang Zhang ◽  
Lisa Liao ◽  
...  

2018 ◽  
Vol 124 ◽  
pp. 418-428 ◽  
Author(s):  
Yanfei Wang ◽  
Long Yu ◽  
Fengwei Xie ◽  
Sheng Li ◽  
Qingjie Sun ◽  
...  




2020 ◽  
Vol 137 (47) ◽  
pp. 49535
Author(s):  
Ying Chen ◽  
Lisha Liao ◽  
Hongsheng Liu ◽  
Yanfei Wang ◽  
Liang Zhang ◽  
...  




2021 ◽  
Vol 22 (17) ◽  
pp. 9399
Author(s):  
Li Ming Lim ◽  
Kunn Hadinoto

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR–chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films’ characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.



2013 ◽  
Vol 98 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Liang Zhang ◽  
Yanfei Wang ◽  
Hongsheng Liu ◽  
Long Yu ◽  
Xingxun Liu ◽  
...  


2014 ◽  
Vol 293 (1) ◽  
pp. 229-237 ◽  
Author(s):  
Liang Zhang ◽  
Yanfei Wang ◽  
Long Yu ◽  
Hongsheng Liu ◽  
George Simon ◽  
...  


2017 ◽  
Vol 70 ◽  
pp. 251-259 ◽  
Author(s):  
Liang Zhang ◽  
Long Yu ◽  
Hongsheng Liu ◽  
Yanfei Wang ◽  
George P. Simon ◽  
...  


2016 ◽  
Vol 153 ◽  
pp. 329-335 ◽  
Author(s):  
Yanfei Wang ◽  
Liang Zhang ◽  
Hongsheng Liu ◽  
Long Yu ◽  
George P. Simon ◽  
...  


2016 ◽  
Vol 136 (6) ◽  
pp. 385-391 ◽  
Author(s):  
Tuyoshi Nonaka ◽  
Shogo Makino ◽  
Motomichi Ohto
Keyword(s):  


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