High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR–chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films’ characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.

Study on the properties of modified starch and its feasibility in crystal dumpling skins

Four kinds of modified starches that are expected to improve the quality of crystal dumpling skins were selected, namely Potato acetate starch, Potato hydroxypropyl starch, Octenyl succinate starch sodium, Acetate cassava starch. Through the determination of the physical indicators of the above four modified starches, and then explore the feasibility of applying them to crystal dumpling skins to improve their quality. Studies have found that the light transmittance of the four modified starches is higher than that of the original crystal dumpling mixed starch, which verifies the feasibility of applying these four modified starches to the crystal dumpling skin to improve its transparency and other characteristics. At the same time, it provides a certain reference value for related research on improving the characteristics of crystal dumpling skin.

Influence of the concentrations of xanthan gum, hydroxypropyl starch and potassium chloride on the flow properties of drilling fluid formulations

Drilling operation of oil wells involves high costs and risks. With recent discoveries of deeper reservoirs and difficult to access, there was an increase in the number of horizontal wells drilled and far-reaching, and, thereat, new challenges with operational problems. Fluids, or muds, drilling are essential to the well drilling process, confirming the need to study and find physical, rheological, and filtration properties, appropriate to the complexities in each section and the drilling stage. Optimized formulation is the one that comprises a safe operation, mitigation of operational problems, environmental protection, low cost, and high productivity. Thus, this paper offers the study of the rheological properties, and determination of filtrate volume, of the aqueous base fluid formulations, developed with polymeric additives. A high performance formulation, presenting technical-economical feasibility for drilling operations, was achieved using 0.43% m/v of viscosifier (xanthan gun), 0.57% m/v of filtrate controller (hydroxypropyl starch) and 4.57% m/v of clay swelling inhibitor (KCl)