Critical evaluation of ToxCast-Reactome predicted toxicity pathway correspondence of the human liver HepG2 activity profile with observed PFOA and PFOS hazards

2021 ◽  
pp. 100212
Author(s):  
Andrey Massarsky ◽  
Jillian A. Parker ◽  
Melinda T. Donnell ◽  
Ernest S. Fung ◽  
Kenneth M. Unice
Keyword(s):  
Human Liver ◽  
Critical Evaluation ◽  
Activity Profile ◽  
Toxicity Pathway

Electron Microscopy of Metal-Matrix Composites

1970 ◽  
Vol 28 ◽  
pp. 404-405
Author(s):  
A. Lawley ◽  
M. R. Pinnel ◽  
A. Pattnaik
Keyword(s):  
Electron Microscopy ◽  
Metal Matrix Composites ◽  
Metal Matrix ◽  
Critical Evaluation ◽  
Elastic Behavior ◽  
Matrix Composites ◽  
Directionally Solidified ◽  
Fracture Characteristics ◽  
Broad Program

As part of a broad program on composite materials, the role of the interface on the micromechanics of deformation of metal-matrix composites is being studied. The approach is to correlate elastic behavior, micro and macroyielding, flow, and fracture behavior with associated structural detail (dislocation substructure, fracture characteristics) and stress-state. This provides an understanding of the mode of deformation from an atomistic viewpoint; a critical evaluation can then be made of existing models of composite behavior based on continuum mechanics. This paper covers the electron microscopy (transmission, fractography, scanning microscopy) of two distinct forms of composite material: conventional fiber-reinforced (aluminum-stainless steel) and directionally solidified eutectic alloys (aluminum-copper). In the former, the interface is in the form of a compound and/or solid solution whereas in directionally solidified alloys, the interface consists of a precise crystallographic boundary between the two constituents of the eutectic.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Critical evaluation of permeation enhancers for oral mucosal drug delivery

2009 ◽  
Vol 00 (00) ◽  
pp. 090810030148087-29
Author(s):  
Harmik Sohi ◽  
Alka Ahuja ◽  
Farhan Jalees Ahmad ◽  
Roop Krishen Khar
Keyword(s):  
Drug Delivery ◽  
Critical Evaluation ◽  
Permeation Enhancers ◽  
Mucosal Drug Delivery

Author response for "Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation"

2020 ◽  
Author(s):  
Rajesh Lamichhane ◽  
Fran Munro ◽  
Thomas W. R. Harrop ◽  
Sara M. Harpe ◽  
Peter K. Dearden ◽  
...  
Keyword(s):  
Human Liver ◽  
Author Response ◽  
Mait Cells

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study

Review of Human Sexuality: A Bibliography and Critical Evaluation of Recent Texts.

1984 ◽  
Vol 29 (7) ◽  
pp. 598-598
Author(s):  
No authorship indicated
Keyword(s):  
Human Sexuality ◽  
Critical Evaluation
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