Astrocytes and neuropsychiatric symptoms in neurodegenerative diseases: Exploring the missing links

2022 ◽  
Vol 72 ◽  
pp. 63-71
Author(s):  
Lucile Ben Haim ◽  
Carole Escartin
Keyword(s):  
Neurodegenerative Diseases ◽  
Neuropsychiatric Symptoms

Restless Legs Syndrome in a Group of Patients With Alzheimer’s Disease

2012 ◽  
Vol 28 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Giuseppina Talarico ◽  
M. Canevelli ◽  
G. Tosto ◽  
N. Vanacore ◽  
F. Letteri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Restless Legs Syndrome ◽  
Neurological Disorder ◽  
Clinical Characteristics ◽  
Dopaminergic System ◽  
Neuropsychiatric Symptoms ◽  
Restless Legs

Background: Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move the legs associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved by movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim of our study was to assess the prevalence and the clinical characteristics of RLS in a cohort of AD patients. Methods: Three hundred and thirty-nine subjects with a diagnosis of AD were recruited. Cognitive, functional, and neuropsychiatric measures were collected at baseline and six-monthly for a 2-years follow-up Results: Fourteen subjects met the RLS criteria. RLS subjects were more frequently male (p:0,006) and younger than AD subject without RLS (p:0,029). MMSE, ADL and IADL were not significantly different. NPI total scores did not differ significantly, however, AD patients with RLS were found to be more apathetic (p:0,001) than AD subjects without RLS. Conclusion: RLS prevalence in our AD cohort was estimated to be about 4%. RLS appeared to be associated with neuropsychiatric symptoms such as apathy. RLS and apathy might share a common pathophysiological basis represented by a dysfunction of the central dopaminergic system

scholarly journals Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 311 ◽  
Author(s):  
Sandeep Malampati ◽  
Ju-Xian Song ◽  
Benjamin Chun-Kit Tong ◽  
Anusha Nalluri ◽  
Chuan-Bin Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Small Molecules ◽  
Neuropsychiatric Symptoms ◽  
Misfolded Protein ◽  
Older Individuals ◽  
Progressive Dementia ◽  
The Brain

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.

scholarly journals Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases

2019 ◽  
Vol 47 (1-2) ◽  
pp. 42-54 ◽  
Author(s):  
Alice Y. Hua ◽  
Jenna L. Wells ◽  
Claudia M. Haase ◽  
Kuan-Hua Chen ◽  
Howard J. Rosen ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Neuropsychiatric Symptoms ◽  
Structural Mri ◽  
Health Problems ◽  
Caregiver Health ◽  
Health Differences ◽  
Patient Variables ◽  
Brain And Behavior ◽  
Brain Data ◽  
The Right

Background: Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound. Aims: To determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship. Methods: In 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and patient behavior and cognitive symptoms. Results: Patient atrophy in the right insula and medial frontal gyrus was associated with worse caregiver health; this relationship was partially mediated by patient neuropsychiatric symptoms, and assessing atrophy in these regions improved predictions of poor caregiver health above and beyond patient behavioral symptoms. Conclusions: This study shows the value of patients’ brain data in identifying caregivers at risk for becoming sick themselves.

scholarly journals Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases?

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Alexei Verkhratsky ◽  
Qing Li ◽  
Sonia Melino ◽  
Gerry Melino ◽  
Yufang Shi
Keyword(s):  
Neurodegenerative Diseases ◽  
Cognitive Deficits ◽  
Neuropsychiatric Symptoms ◽  
Neural Cells ◽  
Brain Ischaemia ◽  
Disturbed Sleep ◽  
The World ◽  
Global Brain Ischaemia ◽  
Global Brain ◽  
The Brain

AbstractThe pandemic of Coronavirus Disease 2019 (COVID-19) presents the world with the medical challenge associated with multifactorial nature of this pathology. Indeed COVID-19 affects several organs and systems and presents diversified clinical picture. COVID-19 affects the brain in many ways including direct infection of neural cells with SARS-CoV-2, severe systemic inflammation which floods the brain with pro-inflammatory agents thus damaging nervous cells, global brain ischaemia linked to a respiratory failure, thromboembolic strokes related to increased intravascular clotting and severe psychological stress. Often the COVID-19 is manifested by neurological and neuropsychiatric symptoms that include dizziness, disturbed sleep, cognitive deficits, delirium, hallucinations and depression. All these indicate the damage to the nervous tissue which may substantially increase the incidence of neurodegenerative diseases and promote dementia.

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