Risk factors for recurrence of venous thromboembolism associated with the use of oral contraceptives

SummaryThird generation oral contraceptives (OCs) are apparently stronger risk factors for venous thromboembolism (VTE) than other OCs, however, the increased risk may be due to confounding by indication related to differences in prescription behaviour.We estimated the risk of VTE associated with use of OCs with and without the presence of Factor V Leiden mutation, protein C-, protein S- or antithrombin deficiency.Sixty-seven cases with VTE were compared with 134 controls. The risk of VTE in the presence of thrombophilia was of the same magnitude for third generation OC users as for users of other OCs; OR: 52.5 (95% CI: 3.7-738.1) and OR: 63.3 (95% CI: 6.2-648.4), respectively.It is unlikely that confounding by indication entirely explains the risk of VTE associated with third generation OCs since the combined effect exceeds what could be explained if this source of error was the only determinant of the association.

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Venous Thromboembolism following Elective Aesthetic Plastic Surgery: A Longitudinal Prospective Study in 1254 Patients

Plastic Surgery International ◽

10.1155/2014/565793 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Denis Souto Valente ◽

Lauro Aita Carvalho ◽

Rafaela Koehler Zanella ◽

Sibelie Valente

Keyword(s):

Risk Factors ◽

Hormone Replacement Therapy ◽

Venous Thromboembolism ◽

Replacement Therapy ◽

Oral Contraceptives ◽

Hormone Replacement ◽

Patient Characteristics ◽

Augmentation Mammoplasty ◽

Postoperative Risk ◽

Short Term Mortality

Background. Venous thromboembolism (VTE) is a disorder with short-term mortality and long-term morbidity. Healthy patients submitted to elective aesthetic plastic surgeries (EAPS) have risk factors to develop VTE not well established yet. The objective of this study was to examine the incidence and risk factors for VTE in these patients. Methods. Longitudinal, prospective (minimum follow-up of 3 months), observational study. Comprehensive information on patient characteristics and surgeries performed was obtained. Preoperative, intraoperative, and postoperative risk factors were analyzed for their association with VTE. Results. A total of 1254 patients were included in the study. Postoperative VTE occurred in 17 (1,35%) of patients. VTE was more frequent in patients more than 40 years old (82.3%). Smoking, patients with 2 or 3 pregnancies, and hormone replacement therapy, and oral contraceptives use presents higher levels of VTE. In this study we have not found any correlation between liposuction, augmentation mammoplasty, mastopexy, and rhinoplasty as an isolated risk factor for VTE. Conclusions. The incidence of VTE in patients undergoing EAPS was 1.35%. Patients with more than 40 years of age, tobacco users, patients with 2 or more pregnancies, and hormone replacement therapy or oral contraceptives use presents higher levels of VTE.

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New concepts in optimal management of anticoagulant therapy for extended treatment of venous thromboembolism

Thrombosis and Haemostasis ◽

10.1160/th06-05-0235 ◽

2006 ◽

Vol 96 (09) ◽

pp. 258-266 ◽

Cited By ~ 14

Author(s):

Mats Ögren ◽

Sam Schulman

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Secondary Prophylaxis ◽

Course Of Disease ◽

Vein Thrombosis ◽

New Concepts ◽

Cardiolipin Antibodies ◽

Risk Factors For Recurrence ◽

Deep Vein

SummaryRecent trials on secondary prophylaxis after venous thromboembolism (VTE) have provided a wealth of data on the risk factors for recurrence and, to some extent, also for bleeding. Some of the results are consistent across the studies, but there are also conflicting data. Certain risk factors, such as pulmonary embolism versus deep vein thrombosis or presence of cardiolipin antibodies, have a more pronounced influence on the risk early in the course of disease. Others, such as hereditary throm- bophilic defects, seem to gain importance over many years of follow-up. Therefore, it can be difficult to make decisions on an individual patient basis. In this article,data from important and illustrative trials have been extracted and compared and controversies highlighted. The conclusions drawn should help clinicians make balanced decisions on the optimal duration of anticoagulation after an episode of VTE.

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P-016: Risk factors of stroke and venous thromboembolism in association with combined oral contraceptives use

Thrombosis Research ◽

10.1016/s0049-3848(17)30114-7 ◽

2017 ◽

Vol 151 ◽

pp. S115

Author(s):

P. Dulíček ◽

E. Ivanová ◽

P. Sadílek ◽

M. Beránek

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Oral Contraceptives ◽

Combined Oral Contraceptives

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OC-14 Risk factors for recurrence in patients with cancer-associated venous thromboembolism: results from the Hokusai-VTE cancer study

Thrombosis Research ◽

10.1016/s0049-3848(21)00156-0 ◽

2021 ◽

Vol 200 ◽

pp. S14-S15

Author(s):

F.T.M. Bosch ◽

T.-F. Wang ◽

M. Di Nisio ◽

A. Segers ◽

J.M. Connors ◽

...

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Cancer Study ◽

Patients With Cancer ◽

Risk Factors For Recurrence

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HORMONE THERAPY AND OTHER RISK FACTORS FOR RECURRENCE OF VENOUS THROMBOEMBOLISM AMONG POSTMENOPAUSAL WOMEN

Maturitas ◽

10.1016/s0378-5122(09)70305-6 ◽

2009 ◽

Vol 63 ◽

pp. S78 ◽

Cited By ~ 1

Author(s):

V. Olié ◽

G. Plu-Bureau ◽

J. Conard ◽

M.-H. Horellou ◽

M. Canonico ◽

...

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Hormone Therapy ◽

Postmenopausal Women ◽

Risk Factors For Recurrence

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Venous Thromboembolism in Women Taking Combined Oral Contraceptives: Risk Factors

Clinical Science ◽

10.1042/cs100015p ◽

2001 ◽

Vol 100 (s44) ◽

pp. 15P-15P

Author(s):

A Egun ◽

A Uzoigwe ◽

G Riding ◽

CN McCollum

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Oral Contraceptives ◽

Combined Oral Contraceptives

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Extension of anticoagulation after venous thromboembolism

Hämostaseologie ◽

10.1055/s-0037-1617168 ◽

2008 ◽

Vol 28 (03) ◽

pp. 110-119 ◽

Cited By ~ 1

Author(s):

S. Schulman

Keyword(s):

Risk Factors ◽

Venous Thromboembolism ◽

Secondary Prophylaxis ◽

Factors Associated ◽

Long Term Follow Up ◽

Risk Factors For Recurrence ◽

Individual Decisions ◽

The Individual

SummaryWhereas every clinician agrees on the need for anticoagulation initially after the diagnosis of venous thromboembolism (VTE), the opinions regarding optimal duration of secondary prophylaxis differ. The decision is complicated by the large number of identified risk factors associated with the risk of recurrence. In addition consideration has to be taken to the risk factors for bleeding and individual patient preferences. Data from long-term follow-up studies up to a decade indicate that some risk factors for recurrence decline and others seem to gain importance with time. In this review data has been extracted from the most illustrative trials to highlight controversies but also where there is consensus in order to give the clinician some support for the individual decisions on extension of anticoagulation after VTE.

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