scholarly journals Age differences in predicting working memory performance from network-based functional connectivity

Cortex ◽  
2020 ◽  
Vol 132 ◽  
pp. 441-459 ◽  
Author(s):  
Rachel N. Pläschke ◽  
Kaustubh R. Patil ◽  
Edna C. Cieslik ◽  
Alessandra D. Nostro ◽  
Deepthi P. Varikuti ◽  
...  
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Age Differences ◽  
Memory Performance

scholarly journals No evidence for changes in GABA concentration, functional connectivity, or working memory following continuous theta burst stimulation over dorsolateral prefrontal cortex

2021 ◽  
Author(s):  
Tribikram Thapa ◽  
Joshua Hendrikse ◽  
Sarah Thompson ◽  
Chao Suo ◽  
Mana Biabani ◽  
...  
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Memory Performance ◽  
Memory Task ◽  
Low Frequency ◽  
Theta Burst Stimulation ◽  
Gaba Concentration ◽  
Dorsolateral Prefrontal ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

Continuous theta burst stimulation (cTBS) is thought to reduce cortical excitability and modulate functional connectivity, possibly by altering cortical inhibition at the site of stimulation. However, most evidence comes from the motor cortex and it remains unclear whether similar effects occur following stimulation over other brain regions. We assessed whether cTBS over left dorsolateral prefrontal cortex altered gamma aminobutyric acid (GABA) concentration, functional connectivity and brain dynamics at rest, and brain activation and memory performance during a working memory task. Seventeen healthy individuals participated in a randomised, sham-controlled, cross-over experiment. Before and after either real or sham cTBS, magnetic resonance spectroscopy was obtained at rest to measure GABA concentrations, whereas functional magnetic resonance imaging (fMRI) was recorded at rest and during an n-back working memory task to measure functional connectivity, brain dynamics (low-frequency fluctuations), and task-related patterns of brain activity. We could not find evidence for changes in GABA concentration (P=0.66, Bayes factor [BF10]=0.07), resting-state functional connectivity (P(FWE)>0.05), resting-state low-frequency fluctuations (P=0.88, BF10=0.04), blood-oxygen level dependent activity during the n-back task (P(FWE) >0.05), or working memory performance (P=0.13, BF10=0.05) following real or sham cTBS. Our findings add to a growing body of literature suggesting the effects of cTBS are highly variable between individuals and question the notion that cTBS is a universal 'inhibitory' paradigm.

Age differences in short-term memory binding are related to working memory performance across the lifespan.

2014 ◽  
Vol 29 (1) ◽  
pp. 140-149 ◽  
Author(s):  
Yana Fandakova ◽  
Myriam C. Sander ◽  
Markus Werkle-Bergner ◽  
Yee Lee Shing
Keyword(s):  
Working Memory ◽  
Age Differences ◽  
Short Term Memory ◽  
Memory Performance ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding

Predicting multilingual effects on executive function and individual connectomes in children: An ABCD study

2021 ◽  
Vol 118 (49) ◽  
pp. e2110811118
Author(s):  
Young Hye Kwon ◽  
Kwangsun Yoo ◽  
Hillary Nguyen ◽  
Yong Jeong ◽  
Marvin M. Chun
Keyword(s):  
Working Memory ◽  
Executive Function ◽  
Functional Connectivity ◽  
Memory Performance ◽  
Occipital Lobe ◽  
Stop Signal Task ◽  
Functional Connectome ◽  
Prediction Approach ◽  
The Brain ◽  
Back Task

While there is a substantial amount of work studying multilingualism’s effect on cognitive functions, little is known about how the multilingual experience modulates the brain as a whole. In this study, we analyzed data of over 1,000 children from the Adolescent Brain Cognitive Development (ABCD) Study to examine whether monolinguals and multilinguals differ in executive function, functional brain connectivity, and brain–behavior associations. We observed significantly better performance from multilingual children than monolinguals in working-memory tasks. In one finding, we were able to classify multilinguals from monolinguals using only their whole-brain functional connectome at rest and during an emotional n-back task. Compared to monolinguals, the multilingual group had different functional connectivity mainly in the occipital lobe and subcortical areas during the emotional n-back task and in the occipital lobe and prefrontal cortex at rest. In contrast, we did not find any differences in behavioral performance and functional connectivity when performing a stop-signal task. As a second finding, we investigated the degree to which behavior is reflected in the brain by implementing a connectome-based behavior prediction approach. The multilingual group showed a significant correlation between observed and connectome-predicted individual working-memory performance scores, while the monolingual group did not show any correlations. Overall, our observations suggest that multilingualism enhances executive function and reliably modulates the corresponding brain functional connectome, distinguishing multilinguals from monolinguals even at the developmental stage.

IC-P-046: MEMORY SYSTEM FUNCTIONAL CONNECTIVITY AND WORKING MEMORY PERFORMANCE IN SUBJECTIVE MEMORY COMPLAINTS

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P46-P46
Author(s):  
Raymond P. Viviano ◽  
Jessica M. Hayes ◽  
Patrick J. Pruitt ◽  
Zachary J. Fernandez ◽  
Sanneke van Rooden ◽  
...  
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Memory Performance ◽  
Memory System ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Complaints

The Role of Anterior Cingulate Cortex in Working Memory is Shaped by Functional Connectivity

2005 ◽  
Vol 17 (7) ◽  
pp. 1026-1042 ◽  
Author(s):  
Agatha Lenartowicz ◽  
Anthony R. McIntosh
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Memory Performance ◽  
Activity Patterns ◽  
Standard Condition ◽  
Memory Task ◽  
Anterior Cingulate ◽  
Connectivity Pattern ◽  
Attention And Memory ◽  
Speed Accuracy

The anterior cingulate (AC) cortex seems to be similarly engaged by attentional and memory processes. We tested the hypothesis that this common activation is best explained by changes in the regions interacting (functionally connected) with AC. Subjects were tested on two variants of a 2-back working memory task: a standard version with strong attentional demands, and a cued version that more strongly promoted memory retrieval. AC activation, measured with functional MRI, was found in both tasks, although more sustained in the standard condition. The regions functionally connected to the AC, and the relation of these activity patterns to memory performance, were completely different across tasks. In the standard task, the pattern related to a speed-accuracy tradeoff, whereas the connectivity pattern unique to the cued task related only to better accuracy. By virtue of these changing patterns of functional connectivity, the contribution of AC to attention-and memory-driven performance was similarly changed.

scholarly journals Functional Connectivity of Resting State as a Biomarker for Working Memory Performance

2016 ◽  
Vol 10 ◽  
Author(s):  
Nese H�den ◽  
Soylu Can ◽  
Irak Metahan ◽  
Adanali Pinar ◽  
Akin Ata
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Resting State ◽  
Memory Performance

Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial

2016 ◽  
Vol 44 (03) ◽  
pp. 489-514 ◽  
Author(s):  
Yujin Jeon ◽  
Binna Kim ◽  
Jieun E. Kim ◽  
Bori R. Kim ◽  
Soonhyun Ban ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Placebo Group ◽  
Functional Connectivity ◽  
Gray Matter ◽  
Controlled Trial ◽  
Memory Performance ◽  
Gray Matter Volume ◽  
Subjective Cognitive Impairment ◽  
Matter Volume

This randomized, double-blind, placebo-controlled trial examined whether the administration of ganglioside, an active ingredient of deer bone extract, can improve working memory performance by increasing gray matter volume and functional connectivity in the default mode network (DMN) in individuals with subjective cognitive impairment. Seventy-five individuals with subjective cognitive impairment were chosen to receive either ganglioside (330[Formula: see text][Formula: see text]g/day or 660[Formula: see text][Formula: see text]g/day) or a placebo for 8 weeks. Changes in working memory performance with treatment of either ganglioside or placebo were assessed as cognitive outcome measures. Using voxel-based morphometry and functional connectivity analyses, changes in gray matter volume and functional connectivity in the DMN were also assessed as brain outcome measures. Improvement in working memory performance was greater in the ganglioside group than in the placebo group. The ganglioside group, relative to the placebo group, showed greater increases in gray matter volume and functional connectivity in the DMN. A significant relationship between increased functional connectivity of the precuneus and improved working memory performance was observed in the ganglioside group. The current findings suggest that ganglioside has cognitive-enhancing effects in individuals with subjective cognitive impairment. Ganglioside-induced increases in gray matter volume and functional connectivity in the DMN may partly be responsible for the potential nootropic effects of ganglioside. The clinical trial was registered with ClinicalTrials.gov (identifier: NCT02379481).

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