Diagnostic value of diffusion-weighted imaging (DWI) for the assessment of the small bowel in patients with inflammatory bowel disease

An altered ceramide composition in patients with inflammatory bowel disease (IBD) has been reported recently. The aim of this study was to evaluate the concentrations of sphingolipids in the serum of treatment-naive children with newly diagnosed IBD and to determine the diagnostic value of the tested lipids in pediatric IBD. The concentrations of sphingolipids in serum samples were evaluated using a quantitative method, an ultra-high-performance liquid chromatography-tandem mass spectrometry in children with Crohn’s disease (CD) (n=34), ulcerative colitis (UC) (n = 39), and controls (Ctr) (n = 24). Among the study groups, the most significant differences in concentrations were noted for C16:0-LacCer, especially in children with CD compared to Ctr or even to UC. Additionally, the relevant increase in C20:0-Cer and C18:1-Cer concentrations were detected in both IBD groups compared to Ctr. The enhanced C24:0-Cer level was observed only in UC, while C18:0-Cer only in the CD group. The highest area under the curve (AUC), specificity, and sensitivity were determined for C16:0-LacCer in CD diagnosis. Our results suggest that the serum LacC16-Cer may be a potential biomarker that distinguishes children with IBD from healthy controls and differentiates IBD subtypes. In addition, C20:0-Cer and C18:0-Cer levels also seem to be closely connected with IBD.

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The small bowel — capsule endoscopy in inflammatory bowel disease

Falk Symposium - Emerging Issues in Inflammatory Bowel Diseases ◽

10.1007/978-1-4020-5702-1_17 ◽

2007 ◽

pp. 159-165

Author(s):

A. C. F. Taylor

Keyword(s):

Inflammatory Bowel Disease ◽

Small Bowel ◽

Capsule Endoscopy ◽

Bowel Disease ◽

Inflammatory Bowel

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Diffusion-weighted MRI in inflammatory bowel disease

The Lancet Gastroenterology & Hepatology ◽

10.1016/s2468-1253(18)30054-2 ◽

2018 ◽

Vol 3 (6) ◽

pp. 433-443 ◽

Cited By ~ 7

Author(s):

Lieven Pouillon ◽

Valérie Laurent ◽

Marc Pouillon ◽

Peter Bossuyt ◽

Christiana Bonifacio ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Diffusion Weighted Mri ◽

Diffusion Weighted ◽

Inflammatory Bowel

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Diffuse Filiform Polyposis With Unique Histology Mimicking Familial Adenomatous Polyposis in a Patient Without Inflammatory Bowel Disease

Archives of Pathology & Laboratory Medicine ◽

10.5858/2007-131-1821-dfpwuh ◽

2007 ◽

Vol 131 (12) ◽

pp. 1821-1824

Author(s):

Gerard J. Oakley III ◽

Wolfgang H. Schraut ◽

Robert Peel ◽

Alyssa Krasinskas

Keyword(s):

Inflammatory Bowel Disease ◽

Small Bowel ◽

Familial Adenomatous Polyposis ◽

Bowel Disease ◽

Nerve Fibers ◽

Normal Colonic Mucosa ◽

Adenomatous Polyposis ◽

Inflammatory Bowel ◽

Filiform Polyposis ◽

Vascular Hamartoma

Abstract Filiform polyposis is an uncommon entity that is most often encountered in the colon of patients with a history of inflammatory bowel disease (IBD). Filiform polyposis is characterized by a large number of “wormlike” polyps lined by histologically normal colonic mucosa. These polyps can mimic adenomatous polyps. Only rare cases without a history or evidence of IBD have been reported. Neuromuscular and vascular hamartoma of the small bowel is a rare, focal disorder characterized by disorganized smooth muscle fascicles throughout the submucosa accompanied by fibrosis, nerve fibers, ganglion cells, and vessels. To our knowledge, there is only one report of this lesion in the large bowel (cecum), where it presented as a mass. Here we report the case of a 50-year-old man with no known history or symptoms of IBD presenting with filiform polyposis involving the entire colon, clinically mimicking familial adenomatous polyposis, and showing histologic features similar to neuromuscular and vascular hamartoma of the small bowel.

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