Diagnostic and therapeutic ionizing radiation and the risk of a first and second primary breast cancer, with special attention for BRCA1 and BRCA2 mutation carriers: A critical review of the literature

2015 ◽  
Vol 41 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Jan C. Drooger ◽  
Maartje J. Hooning ◽  
Caroline M. Seynaeve ◽  
Margreet H.A. Baaijens ◽  
Inge Marie Obdeijn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Critical Review ◽  
Primary Breast Cancer ◽  
Brca2 Mutation ◽  
Second Primary ◽  
Review Of The Literature ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

scholarly journals Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry

2015 ◽  
Vol 151 (3) ◽  
pp. 653-660 ◽  
Author(s):  
Tehillah S. Menes ◽  
Mary Beth Terry ◽  
David Goldgar ◽  
Irene L. Andrulis ◽  
Julia A. Knight ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cumulative Incidence ◽  
Primary Breast Cancer ◽  
Brca2 Mutation ◽  
Second Primary ◽  
Brca1 And Brca2 ◽  
Breast Cancer Family ◽  
Cancer Family ◽  
Mutation Carriers

119 Efficacy of Bilateral Risk-reducing Mastectomy on Primary Breast Cancer Risk in Healthy BRCA1 and BRCA2 Mutation Carriers

2012 ◽  
Vol 48 ◽  
pp. S75
Author(s):  
A. Heemskerk-Gerritsen ◽  
M. Hooning ◽  
M.M.A. Tilanus-Linthorst ◽  
A. Jager ◽  
C.H.M. van Deurzen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Primary Breast Cancer ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers ◽  
Risk Reducing

Contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers and other high-risk women in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 1509-1509
Author(s):  
B. E. Kiely ◽  
M. A. Jenkins ◽  
J. M. McKinley ◽  
M. L. Friedlander ◽  
P. C. Weideman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brca2 Mutation ◽  
Familial Risk ◽  
Breast Conservation ◽  
Second Primary ◽  
Brca1 And Brca2 ◽  
Mutation Status ◽  
Younger Women ◽  
Mutation Carriers ◽  
Risk Reducing

1509 Background: Contralateral risk-reducing mastectomy (CRRM) reduces contralateral breast cancer (BC) risk by up to 97%. Few studies have examined the prevalence and predictors of CRRM in BC patients at high familial risk of a second primary BC. Methods: Participants were women with unilateral BC and a strong family history of the disease, including BRCA1 and BRCA2 mutation carriers. Data were collected by interview, self-administered questionnaire, and review of pathology and surgical reports. Associations between having CRRM and potential predictors were assessed using multivariate logistic regression. Results: Of 1018 study participants (median follow-up 5.5 years), 154 (15%) underwent CRRM. The median time from initial BC to CRRM was 1 year. More likely to undergo CRRM were women who were younger at the time of their BC diagnosis (odds ratio [OR] = 0.94 per year of age, p < 0.001), those diagnosed more recently (OR = 1.16 per calendar year, p < 0.001), those who underwent mastectomy rather than breast conservation as their initial definitive BC treatment (OR = 5.2, p < 0.001) and those who underwent risk-reducing salpingo-oophorectomy (OR = 3.4, p < 0.001). BRCA1/2 mutation status and tumor characteristics were not independently associated with CRRM uptake. A contralateral BC event occurred in 177 (20.5%) of the 864 women who did not have CRRM, compared with one chest wall event (0.6%) in the 154 women post-CRRM. Conclusions: Younger women with more recently diagnosed BC treated with mastectomy were most likely to elect CRRM. BRCA1/2 mutation status and the competing risk of BC recurrence and death did not appear to influence decision making. No significant financial relationships to disclose.

scholarly journals The frequency and outcome of breast cancer risk-reducing surgery in finnish BRCA1 and BRCA2 mutation carriers

2013 ◽  
Vol 103 (1) ◽  
pp. 34-40 ◽  
Author(s):  
L. Koskenvuo ◽  
C. Svarvar ◽  
S. Suominen ◽  
K. Aittomäki ◽  
T. Jahkola
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers ◽  
Risk Reducing

The CYP17A1 −34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers

2010 ◽  
Vol 126 (2) ◽  
pp. 521-527 ◽  
Author(s):  
Bella Kaufman ◽  
Yael Laitman ◽  
Elad Ziv ◽  
Ute Hamann ◽  
Diana Torres ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

scholarly journals Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers

2011 ◽  
Vol 104 (9) ◽  
pp. 1384-1392 ◽  
Author(s):  
K Metcalfe ◽  
S Gershman ◽  
H T Lynch ◽  
P Ghadirian ◽  
N Tung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contralateral Breast Cancer ◽  
Brca2 Mutation ◽  
Contralateral Breast ◽  
Brca1 And Brca2 ◽  
Mutation Carriers

Oral contraceptives and breast cancer risk in BRCA1 and BRCA2 mutation carriers

2009 ◽  
Vol 1 (3) ◽  
pp. 139-147
Author(s):  
Jane C. Figueiredo ◽  
Robert W. Haile ◽  
Jonine L. Bernstein
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Oral Contraceptives ◽  
Brca2 Mutation ◽  
Brca1 And Brca2 ◽  
Mutation Carriers
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