scholarly journals Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling

2020 ◽  
Vol 53 (6) ◽  
pp. 627-645.e7 ◽  
Author(s):  
Tim Sen Wang ◽  
Isabelle Coppens ◽  
Anna Saorin ◽  
Nathan Ryan Brady ◽  
Anne Hamacher-Brady
Keyword(s):  
Mitochondrial Permeabilization

scholarly journals Limited Mitochondrial Permeabilization Is an Early Manifestation of Palmitate-induced Lipotoxicity in Pancreatic β-Cells

2007 ◽  
Vol 283 (12) ◽  
pp. 7936-7948 ◽  
Author(s):  
Vasilij Koshkin ◽  
Feihan F. Dai ◽  
Christine A. Robson-Doucette ◽  
Catherine B. Chan ◽  
Michael B. Wheeler
Keyword(s):  
Β Cells ◽  
Pancreatic Β Cells ◽  
Mitochondrial Permeabilization ◽  
Early Manifestation

scholarly journals Differential effects of Bcl-2 and caspases on mitochondrial permeabilization during endogenous or exogenous reactive oxygen species-induced cell death

2012 ◽  
Vol 28 (4) ◽  
pp. 239-253 ◽  
Author(s):  
Vincent Rincheval ◽  
Marie Bergeaud ◽  
Lise Mathieu ◽  
Jacqueline Leroy ◽  
Arnaud Guillaume ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Differential Effects ◽  
Mitochondrial Permeabilization

scholarly journals Involvement of Ca2+ and ROS in α-tocopheryl succinate-induced mitochondrial permeabilization

2010 ◽  
Vol 127 (8) ◽  
pp. 1823-1832 ◽  
Author(s):  
Vladimir Gogvadze ◽  
Erik Norberg ◽  
Sten Orrenius ◽  
Boris Zhivotovsky
Keyword(s):  
Tocopheryl Succinate ◽  
Mitochondrial Permeabilization

scholarly journals An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution

2021 ◽  
Author(s):  
Andreas Ulrich Lindner ◽  
Manuela Salvucci ◽  
Elizabeth McDonough ◽  
Sanghee Cho ◽  
Xanthi Stachtea ◽  
...  
Keyword(s):  
Single Cell ◽  
Cancer Cells ◽  
Tumor Heterogeneity ◽  
Cell Lineage ◽  
Tissue Microarrays ◽  
Response To Therapy ◽  
Cancer Tissue ◽  
Enhanced Sensitivity ◽  
Mitochondrial Permeabilization ◽  
Apoptosis Proteins

AbstractCancer cells’ ability to inhibit apoptosis is key to malignant transformation and limits response to therapy. Here, we performed multiplexed immunofluorescence analysis on tissue microarrays with 373 cores from 168 patients, segmentation of 2.4 million individual cells, and quantification of 18 cell lineage and apoptosis proteins. We identified an enrichment for BCL2 in immune, and BAK, SMAC, and XIAP in cancer cells. Ordinary differential equation-based modeling of apoptosis sensitivity at single-cell resolution was conducted and an atlas of inter- and intra-tumor heterogeneity in apoptosis susceptibility generated. Systems modeling at single-cell resolution identified an enhanced sensitivity of cancer cells to mitochondrial permeabilization and executioner caspase activation compared to immune and stromal cells, but showed significant inter- and intra-tumor heterogeneity.

Bcl-xL inhibits tBid and Bax via distinct mechanisms

2020 ◽  
Author(s):  
Ana Garcia ◽  
Fabronia Murad
Keyword(s):  
Interaction Network ◽  
Complex Interaction ◽  
Cellular Membranes ◽  
Mitochondrial Permeabilization

The proteins of the Bcl-2 family are key regulators of apoptosis. They form a complex interaction network in the cytosol and in the cellular membranes, whose outcome determines mitochondrial permeabilization...

Glycation of mitochondrial ATP synthase is involved in the increased vulnerability of senescent cardiomyocytes to mitochondrial permeabilization and death

2018 ◽  
Vol 120 ◽  
pp. 2
Author(s):  
D. Bou-Teen ◽  
M. Ruiz-Meana ◽  
E. Miro-Casas ◽  
M. Minguet ◽  
C. Castañs ◽  
...  
Keyword(s):  
Atp Synthase ◽  
Mitochondrial Atp Synthase ◽  
Mitochondrial Permeabilization

Mitochondrial Permeabilization: From Lethality to Vitality

2016 ◽  
pp. 213-226 ◽  
Author(s):  
Andrew Oberst ◽  
Gabriel Ichim ◽  
Stephen W. G. Tait
Keyword(s):  
Mitochondrial Permeabilization

scholarly journals Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

2015 ◽  
Vol 58 (5) ◽  
pp. 900
Author(s):  
Gabriel Ichim ◽  
Jonathan Lopez ◽  
Shafiq U. Ahmed ◽  
Nathiya Muthalagu ◽  
Evangelos Giampazolias ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Genomic Instability ◽  
Mitochondrial Permeabilization

scholarly journals Phosphorylation of DYNLT1 at serine 82 regulates microtubule stability and mitochondrial permeabilization in hypoxia

2013 ◽  
Vol 36 (4) ◽  
pp. 322-332 ◽  
Author(s):  
Xue Xu ◽  
Qiong Zhang ◽  
Jiong-yu Hu ◽  
Dong-xia Zhang ◽  
Xu-pin Jiang ◽  
...  
Keyword(s):  
Microtubule Stability ◽  
Mitochondrial Permeabilization
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