Many large studies have investigated the prevention of type 2 diabetes in people at high risk of the condition, usually with changes in diet and physical activity levels. It is estimated that 2.25 million people in the UK have type 2 diabetes, with significant personal and healthcare costs, and the value of preventative measures in tackling this enormous public health challenge are well described. The Norfolk Diabetes Prevention Study (Norfolk DPS) will screen 10,000 people at risk of type 2 diabetes over five years, randomising 950 people with ‘pre-diabetes’ into a 36-month randomised controlled trial (three-armed study) of a novel diet and lifestyle intervention. The Norfolk DPS team is multidisciplinary and the intervention will be delivered by healthcare professionals in group settings. One arm will be part delivered by lay mentors who have existing type 2 diabetes. There is no UK-validated diet and lifestyle intervention for the prevention of type 2 diabetes in high risk groups that has been tested in a controlled trial, and an intervention delivered by those with existing type 2 diabetes has not been studied. The Norfolk DPS will provide further evidence in these areas.
Effect of maternal lifestyle intervention on metabolic health and adiposity of offspring: Findings from the Finnish Gestational Diabetes Prevention Study (RADIEL)
