A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2

2010 ◽  
Vol 87 (3) ◽  
pp. e23-e25 ◽  
Author(s):  
Lindsey A. Loomba-Albrecht ◽  
Maryam Jame ◽  
Andrew A. Bremer
Keyword(s):  
Gene Mutation ◽  
Maturity Onset Diabetes ◽  
Glucokinase Gene ◽  
C Peptide ◽  
Onset Diabetes

Functional characterization of two novel splicing mutations of glucokinase gene associated with maturity-onset diabetes of the young type 2 (MODY2)

2014 ◽  
Vol 48 (2) ◽  
pp. 248-253 ◽  
Author(s):  
E. L. Igudin ◽  
P. V. Spirin ◽  
V. S. Prasolov ◽  
N. A. Zubkova ◽  
E. E. Petryaikina ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Maturity Onset Diabetes ◽  
Glucokinase Gene ◽  
Splicing Mutations ◽  
Onset Diabetes

scholarly journals Childhood obesity complicating the differential diagnosis of maturity-onset diabetes of the young and type 2 diabetes

2007 ◽  
Vol 0 (0) ◽  
pp. 071127170524002-??? ◽  
Author(s):  
Naomi Weintrob ◽  
Eti Stern ◽  
Yaffa Klipper-Aurbach ◽  
Moshe Phillip ◽  
Galia Gat-Yablonski
Keyword(s):  
Type 2 Diabetes ◽  
Differential Diagnosis ◽  
Childhood Obesity ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes

Common Variants in Maturity-Onset Diabetes of the Young Genes and Future Risk of Type 2 Diabetes

Diabetes ◽  
2008 ◽  
Vol 57 (6) ◽  
pp. 1738-1744 ◽  
Author(s):  
J. Holmkvist ◽  
P. Almgren ◽  
V. Lyssenko ◽  
C. M. Lindgren ◽  
K.-F. Eriksson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Maturity Onset Diabetes ◽  
Common Variants ◽  
Onset Diabetes ◽  
Future Risk

scholarly journals Analysis of the glucokinase gene in Iranian families with maturity onset diabetes of the young

2013 ◽  
Vol 03 (04) ◽  
pp. 192-198
Author(s):  
Meisam Javadi ◽  
Houshang Rafatpanah ◽  
Seyed Morteza Taghavi ◽  
Jalil Tavakolafshari ◽  
Rashin Ganjali ◽  
...  
Keyword(s):  
Maturity Onset Diabetes ◽  
Glucokinase Gene ◽  
Onset Diabetes

Linkage of maturity-onset diabetes of the young to the glucokinase gene-evidence of genetic heterogeneity

1993 ◽  
Vol 21 (1) ◽  
pp. 24S-24S
Author(s):  
AT Hattersley ◽  
PJ Saker ◽  
P Patel ◽  
Y-MD Lo ◽  
R Page ◽  
...  
Keyword(s):  
Genetic Heterogeneity ◽  
Maturity Onset Diabetes ◽  
Glucokinase Gene ◽  
Onset Diabetes

Maturity-Onset Diabetes of the Young (MODY): Genetic Causes, Clinical Characteristics, Considerations for Testing, and Treatment Options

Endocrines ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 485-501
Author(s):  
Zoltan Antal
Keyword(s):  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Treatment Options ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes ◽  
Inappropriate Treatment ◽  
Monogenic Forms Of Diabetes ◽  
Initial Description

Maturity Onset Diabetes of the Young (MODY) encompasses a group of rare monogenic forms of diabetes distinct in etiology and clinical presentation from the more common forms of Type 1 (autoimmune) and Type 2 diabetes. Since its initial description as a clinical entity nearly 50 years ago, the underlying genetic basis for the various forms of MODY has been increasingly better elucidated. Clinically, the diagnosis may be made in childhood or young adulthood and can present as overt hyperglycemia requiring insulin therapy or as a subtle form of slowly progressive glucose impairment. Due to the heterogeneity of clinical symptoms, patients with MODY may be misdiagnosed as possessing another form of diabetes, resulting in potentially inappropriate treatment and delays in screening of affected family members and associated comorbidities. In this review, we highlight the various known genetic mutations associated with MODY, clinical presentation, indications for testing, and the treatment options available.

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