Comparison of the artus Epstein–Barr virus (EBV) PCR kit and the Abbott RealTime EBV assay for measuring plasma EBV DNA loads in allogeneic stem cell transplant recipients

2017 ◽  
Vol 88 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Víctor Vinuesa ◽  
Carlos Solano ◽  
Estela Giménez ◽  
David Navarro
Keyword(s):  
Stem Cell ◽  
Epstein Barr Virus ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Transplant Recipients ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

EBV Associated Post-Transplant Lymphoproliferative Disorder Complicated with Haemophagocytic Lymphohistiocytosis After Allogeneic Stem Cell Transplant: A Rare Complication with Fatal Outcome

2020 ◽  
Vol 4 (02) ◽  
pp. 49-51
Author(s):  
Tangia Muquith
Keyword(s):  
Stem Cell ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Post Transplant ◽  
Barr Virus ◽  
Epstein Barr

Epstein –Barr virus related post-transplant lymphoproliferative disorder is a fatal and life-threatening complication because of immunocompromised state.1 Haemophagocytic lymphohistiocytosis is a sign of poor outcome in EBV associated PTLD after allogeneic stem cell transplantation. It is particularly common when in vivo T cell depletion strategies have been applied.2 In both situations, post-transplant lymphoproliferative disorder and Haemophagocytic lymphohistiocytosis, infection with EBV is the key mechanism. Here I present a case of 29 years old female with acute myeloid leukaemia after second allogeneic stem cell transplant, who developed PTLD complicated with Haemophagocytic lymphohistiocytosis secondary to Epstein – Barr virus (EBV) infection. Patient was treated with chemo immunotherapy and responded but ultimately died after 100 days of transplant. The association of HLH and EBV related PTLD is rare and data on outcome of these patients are limited with very high mortality.

scholarly journals Investigation of Epstein-Barr Virus and Parvovirus B19 DNA in Allogeneic Stem Cell Transplant Patients

2014 ◽  
Vol 31 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Altay Atalay ◽  
Selma Gökahmetoğlu ◽  
Süleyman Durmaz ◽  
İdris Kandemir ◽  
Derya Sağlam ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epstein Barr Virus ◽  
Stem Cell Transplant ◽  
Parvovirus B19 ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Barr Virus ◽  
Transplant Patients ◽  
Epstein Barr

scholarly journals Retrospective evaluation of serum Epstein Barr virus DNA levels in 406 allogeneic stem cell transplant patients

Haematologica ◽  
2007 ◽  
Vol 92 (6) ◽  
pp. 819-825 ◽  
Author(s):  
E. Juvonen ◽  
S. Aalto ◽  
J. Tarkkanen ◽  
L. Volin ◽  
K. Hedman ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epstein Barr Virus ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Retrospective Evaluation ◽  
Barr Virus ◽  
Transplant Patients ◽  
Epstein Barr

scholarly journals Post-transplant lymphoproliferative disorder in childhood

2014 ◽  
Vol 155 (8) ◽  
pp. 313-318
Author(s):  
Anita Stréhn ◽  
László Szőnyi ◽  
Gergely Kriván ◽  
Lajos Kovács ◽  
György Reusz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Lung Transplant ◽  
Epstein Barr Virus ◽  
Stem Cell Transplant ◽  
Lymphoproliferative Disease ◽  
Solid Organ ◽  
Cell Transplant ◽  
Post Transplant ◽  
Barr Virus ◽  
Epstein Barr

Introduction: Among possible complications of transplantation the post-transplant lymphoproliferative disease due to immunosuppressive therapy is of paramount importance. In most cases the direct modulating effect of Epstein–Barr virus on immune cells can be documented. Aim: The aim of the authors was to evaluate the incidence os post-transplant lymphoproliferative diseases in pediatric transplant patients in Hungary. Method: The study group included kidney, liver and lung transplant children followed up at the 1st Department of Pediatrics, Semmelweis University, Budapest and stem cell transplant children at Szent László Hospital, Budapest. Data were collected from 78 kidney, 109 liver and 17 lung transplant children as well as from 243 children who underwent allogenic stem cell transplantation. Results: Between 1998 and 2012, 13 children developed post-transplant lymphoproliferative disorder (8 solid organ transplanted and 5 stem cell transplanted children). The diagnosis was based on histological findings in all cases. Mortality was 3 out of the 8 solid organ transplant children and 4 out of the 5 stem cell transplant children. The highest incidence was observed among lung transplant children (17.6%). Conclusions: These data indicate that post-transplant lymphoproliferative disease is a rare but devastating complication of transplantation in children. The most important therapeutic approaches are reduction of immunosuppressive therapy, chemotherapy and rituximab. Early diagnosis may improve clinical outcome and, therefore, routine polymerase chain reaction screening for Epstein–Barr virus of high risk patients is recommended. Orv. Hetil., 2014, 155(8), 313–318.

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