Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival

DNA Repair ◽  
2005 ◽  
Vol 4 (7) ◽  
pp. 814-825 ◽  
Author(s):  
Florence Dequen ◽  
Steve N. Gagnon ◽  
Serge Desnoyers
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Dna Damage Response ◽  
Damage Response ◽  
Ionizing Radiations

scholarly journals Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

2016 ◽  
Vol 186 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Kalpana Mujoo ◽  
E. Brian Butler ◽  
Raj K. Pandita ◽  
Clayton R. Hunt ◽  
Tej K. Pandita
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Pluripotent Stem Cells ◽  
Damage Response ◽  
Ionizing Radiations

scholarly journals A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes

2017 ◽  
Vol 233 (4) ◽  
pp. 2781-2790 ◽  
Author(s):  
Matthias Rieckher ◽  
Arturo Bujarrabal ◽  
Markus A. Doll ◽  
Najmeh Soltanmohammadi ◽  
Björn Schumacher
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Experimental Model ◽  
Dna Damage Response ◽  
Disease Genes ◽  
Damage Response

Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression

DNA Repair ◽  
2007 ◽  
Vol 6 (3) ◽  
pp. 329-343 ◽  
Author(s):  
Jean-François St-Laurent ◽  
Steve N. Gagnon ◽  
Florence Dequen ◽  
Isabelle Hardy ◽  
Serge Desnoyers
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Dna Damage Response ◽  
Genes Expression ◽  
Damage Response

scholarly journals Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos

2007 ◽  
Vol 178 (5) ◽  
pp. 887-887
Author(s):  
Antonia H. Holway ◽  
Seung-Hwan Kim ◽  
Adriana La Volpe ◽  
W. Matthew Michael
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase

2018 ◽  
Author(s):  
Charlie Longtine ◽  
Stephen Frenk ◽  
Shawn Ahmed
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Dna Damage Response ◽  
Small Rna ◽  
Small Rnas ◽  
Argonaute Protein ◽  
Heterochromatin Formation ◽  
Damage Response ◽  
The Stability ◽  
Telomere Erosion

AbstractTelomerase deficiency in human somatic cells results in telomere erosion and senescence. Small RNAs that target telomeres have been observed in diverse organisms but their functions are not well characterized. We define an endogenous small RNA pathway in Caenorhabditis elegans that promotes heterochromatin formation at telomeres via Dicer, the perinuclear Argonaute protein WAGO-1 and the nuclear Argonaute protein HRDE-1. Loss of telomerase induces biogenesis of siRNAs that target the telomeric lncRNA TERRA, whereas loss of both telomerase and small RNA-mediated telomeric silencing induces TERRA expression, DNA damage, and an accelerated sterility phenotype. These phenotypes can be rescued by exogenous telomeric siRNAs or by loss of the DNA damage response protein EXO-1. Thus, endogenous siRNAs interact with TERRA to promote heterochromatin formation in a manner that is critical for the stability of naturally eroding telomeres. We propose that small RNA-mediated genome silencing could be broadly relevant to regulation of proliferative aging.

scholarly journals Bisphenol A exposure triggers apoptosis via three signaling pathways in Caenorhabditis elegans

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32624-32631 ◽  
Author(s):  
Yun Wang ◽  
Lianfeng Zhang ◽  
Xun Luo ◽  
Shunchang Wang ◽  
Yuanyuan Wang
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Growth Factor ◽  
Bisphenol A ◽  
Signaling Pathways ◽  
Dna Damage Response ◽  
Mitogen Activated Protein Kinase ◽  
Mapk Cascades ◽  
Damage Response ◽  
Mitogen Activated Protein

Bisphenol A can trigger germline apoptosis via three signaling pathways including DNA damage response (DDR) pathway, mitogen-activated protein kinase (MAPK) cascades and insulin-like growth factor-1 (IGF-1) network in Caenorhabditis elegans.

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