Impairment of the non-homologous end joining and homologous recombination pathways of DNA double strand break repair: Impact on spontaneous and radiation-induced mammary and intestinal tumour risk in Apc mice

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Dna Double Strand Break ◽

Intestinal Tumour ◽

Radiation Induced ◽

Break Repair ◽

Abstract 1352: Inactivation of factors of DNA double-strand break repair by homologous recombination or non-homologous end-joining leads to frequent catastrophic genomic events in murine and human tumors

10.1158/1538-7445.am2018-1352 ◽

2018 ◽

Author(s):

Manasi Ratnaparkhe ◽

John Wong ◽

Pei-Chi Wei ◽

Mario Hlevnjak ◽

Paul Northcott ◽

...

Keyword(s):

Strand Break ◽

Double Strand Break ◽

Human Tumors ◽

End Joining ◽

Dna Double Strand Break ◽

Break Repair ◽

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

The EMBO Journal ◽

10.1093/emboj/17.18.5497 ◽

1998 ◽

Vol 17 (18) ◽

pp. 5497-5508 ◽

Cited By ~ 766

Author(s):

Minoru Takata ◽

Masao S. Sasaki ◽

Eiichiro Sonoda ◽

Ciaran Morrison ◽

Mitsumasa Hashimoto ◽

...

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Dna Double Strand Break ◽

Break Repair ◽

Abstract P2-05-08: Integrin alpha6beta4 signaling switches double strand break repair from homologous recombination to non-homologous end joining to alter TNBC cells response to cisplatin

10.1158/1538-7445.sabcs19-p2-05-08 ◽

2020 ◽

Author(s):

Min Chen ◽

Brock Marrs ◽

Lei Qi ◽

Teresa Knifley ◽

Stuart G Jarrett ◽

...

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Integrin Alpha6beta4 ◽

Break Repair ◽

End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

DNA Repair ◽

10.1016/j.dnarep.2016.05.011 ◽

2016 ◽

Vol 43 ◽

pp. 57-68 ◽

Cited By ~ 24

Author(s):

Vijay Menon ◽

Lawrence F. Povirk

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Dna Double Strand Break ◽

Break Repair ◽

Stochastic Simulation of DNA Double-Strand Break Repair by Non-homologous End Joining Based on Track Structure Calculations

Radiation Research ◽

10.1667/rr1965.1 ◽

2010 ◽

Vol 173 (5) ◽

pp. 677-688 ◽

Cited By ~ 54

Author(s):

Werner Friedland ◽

Peter Jacob ◽

Pavel Kundrát

Keyword(s):

Stochastic Simulation ◽

Strand Break ◽

Double Strand Break ◽

Track Structure ◽

End Joining ◽

Dna Double Strand Break ◽

Break Repair ◽

Non Homologous End Joining ◽

Structure Calculations

158 Double strand break repair in mammalian cells: competition between homologous recombination and non-homologous end joining through cell cycle

Radiotherapy and Oncology ◽

10.1016/s0167-8140(04)82025-5 ◽

2004 ◽

Vol 73 ◽

pp. S73-S74

Keyword(s):

Cell Cycle ◽

Mammalian Cells ◽

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Break Repair ◽

DNA Double-Strand Break Repair Through Non-Homologous End-Joining: Recruitment and Assembly of the Players

DNA Repair ◽

10.5772/21262 ◽

2011 ◽

Author(s):

Radhika Pankaj ◽

Yoshihisa Matsumoto

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Dna Double Strand Break ◽

Break Repair ◽

Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair

Oncology Reports ◽

10.3892/or.2018.6217 ◽

2018 ◽

Cited By ~ 7

Author(s):

Jun Dong ◽

Yufeng Ren ◽

Tian Zhang ◽

Zhenyu Wang ◽

Clifton Ling ◽

...

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Radiation Induced ◽

Break Repair ◽

Abstract 2561: DNA-PKCS deacetylation by SIRT2 promotes DNA double-strand break repair by non-homologous end joining

10.1158/1538-7445.sabcs18-2561 ◽

2019 ◽

Author(s):

PamelaSara E. Head ◽

Nagaraju P. Ganji ◽

Shi-Ya Wang ◽

Duc Duong ◽

Hui Zhang ◽

...

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Dna Double Strand Break ◽

Break Repair ◽

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

Oncogene ◽

10.1038/onc.2013.460 ◽

2013 ◽

Vol 33 (45) ◽

pp. 5262-5273 ◽

Cited By ~ 49

Author(s):

M M Chitnis ◽

K A Lodhia ◽

T Aleksic ◽

S Gao ◽

A S Protheroe ◽

...

Keyword(s):

Strand Break ◽

Double Strand Break ◽

End Joining ◽

Break Repair ◽