PP-108. Comparing the efficacy of nebulizer rhDNase and hypertonic saline as monotherapy and combined treatment of persistent atelectasis in mechanically ventilated newborns

2010 ◽  
Vol 86 ◽  
pp. S61
Author(s):  
Huseyin Altunhan ◽  
Ali Annagur ◽  
Sevgi Pekcan ◽  
Rahmi Ors ◽  
Hasan Koç
Keyword(s):  
Hypertonic Saline ◽  
Combined Treatment ◽  
Mechanically Ventilated

Combined Treatment of Severe Hyponatremia Due to Inappropriate Antidiuretic Hormone Secretion

PEDIATRICS ◽  
1982 ◽  
Vol 69 (5) ◽  
pp. 610-612
Author(s):  
Zvi Weizman ◽  
Kalman Goitein ◽  
Yair Amit ◽  
Uri Wald ◽  
Heddy Landau
Keyword(s):  
Antidiuretic Hormone ◽  
Hypertonic Saline ◽  
Serum Sodium ◽  
Combined Treatment ◽  
Hormone Secretion ◽  
Urinary Sodium ◽  
Surgical Removal ◽  
Hypertonic Saline Solution ◽  
Deoxycorticosterone Acetate ◽  
Low Serum

A 6-year-old girl developed generalized seizures followed by coma, five days after surgical removal of a craniopharyngioma. Low serum sodium levels and low serum osmolality with inappropriately high urinary sodium output confirmed the diagnosis of inappropriate antidiuretic hormone (ADH) secretion. Treatment with 3% hypertonic saline solution and repeated doses of furosemide (1 mg/kg) improved her clinical condition; serum sodium levels, however, rose slowly and urinary excretion remained high. Deoxycorticosterone acetate (DOCA), 4 mg/sq m/day, was added to the above regimen. A striking clinical improvement was noted. Serum sodium levels returned to normal with a concomitant sharp decline in urinary sodium output. The clinical course of this patient demonstrates the efficacy of the addition of deoxycorticosterone acetate to hypertonic saline and furosemide in the treatment of severe, lifethreatening hyponatremia due to the syndrome of inappropriate antidiuretic hormone seretion.

scholarly journals Prophylactic Use of Nebulized Hypertonic Saline in Mechanically Ventilated Children: A Randomized Blinded Pilot Study

2016 ◽  
Vol 61 (5) ◽  
pp. 586-592 ◽  
Author(s):  
S. L. Shein ◽  
J. T. Gallagher ◽  
K. M. Deakins ◽  
D. M. Weinert
Keyword(s):  
Pilot Study ◽  
Hypertonic Saline ◽  
Mechanically Ventilated ◽  
Prophylactic Use

scholarly journals Hypertonic saline stimulates vagal afferents that respond to lung deflation

2019 ◽  
Vol 317 (6) ◽  
pp. R814-R817
Author(s):  
Juan Guardiola ◽  
Mohamed Saad ◽  
Jerry Yu
Keyword(s):  
Hypertonic Saline ◽  
Single Unit ◽  
Direct Injection ◽  
Control Level ◽  
Receptive Fields ◽  
Vagal Afferents ◽  
Lung Inflation ◽  
Mechanically Ventilated ◽  
Lung Deflation ◽  
Increased Activity

In our present studies, we seek to determine whether increased osmolarity stimulates deflation-activated receptors (DARs). In anesthetized, open-chest, and mechanically ventilated rabbits, we recorded single-unit activities from typical slowly adapting receptors (SARs; responding only to lung inflation) and DAR-containing SARs (DAR-SARs; responding to both lung inflation and deflation) and identified their receptive fields in the lung. We examined responses of these two groups of pulmonary sensory units to direct injection of hypertonic saline (8.1% sodium chloride; 9-fold in tonicity) into the receptive fields. Hypertonic saline decreased the activity in most SAR units from 40.3 ± 5.4 to 34.8 ± 4.7 imp/s ( P < 0.05, n = 12). In contrast, it increased the activity in DAR-SAR units quickly and significantly from 15.9 ± 2.2 to 43.4 ± 10.0 imp/s ( P < 0.01, n = 10). Many units initially had increased activity, mainly in the deflation phase. DAR-SAR activities largely returned to the control level 30 s after injection. Since hypertonic saline stimulated DAR-SAR units but not SAR units, we conclude that hypertonic saline activates DARs.

Hemodynamic effects of combined treatment with oxygen and hypertonic saline in hemorrhagic shock*

2006 ◽  
Vol 34 (11) ◽  
pp. 2784-2791 ◽  
Author(s):  
Vera I. Brod ◽  
Michael M. Krausz ◽  
Mark Hirsh ◽  
Yochai Adir ◽  
Haim Bitterman
Keyword(s):  
Hemorrhagic Shock ◽  
Hypertonic Saline ◽  
Combined Treatment ◽  
Hemodynamic Effects

Physiological and hypertonic saline solutions impair ciliary activity in vitro

2000 ◽  
Vol 25 (4) ◽  
pp. 331-332
Author(s):  
W.M. Boek ◽  
N. Keles ◽  
K. Graamans ◽  
E.H. Huizing
Keyword(s):  
Hypertonic Saline ◽  
Ciliary Activity ◽  
Saline Solutions

Hypertonic saline in traumatic brain injury: Current status

2004 ◽  
Vol 1 (2) ◽  
pp. 15-20 ◽  
Author(s):  
Kavita Sandhu ◽  
TVSP Murthy ◽  
Brig T Prabhakar
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hypertonic Saline ◽  
Current Status

Hybrid treatment of multilevel revascularization in patients with peripheral arterial disease – a multi-centre study in Korea

VASA ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Soon Cheon Lee ◽  
Jin Hyun Joh ◽  
Jeong-Hwan Chang ◽  
Hyung-Kee Kim ◽  
Jang Yong Kim ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Combined Treatment ◽  
Ankle Brachial Index ◽  
Primary Patency ◽  
Limb Ischaemia ◽  
University Hospitals ◽  
Multi Centre Study ◽  
Free Survival ◽  
Technical Success Rate ◽  
Hybrid Treatment

Abstract. Background: Endovascular treatment is an alternative first-line management for peripheral artery disease (PAD). Hybrid treatment (HT) is defined as a combined treatment for patients with PAD using endovascular and open surgery, simultaneously performed in an operating room. The results of HT are reportedly good for multilevel revascularization (MR) in patients with chronic limb ischaemia, and even in older high-risk patients. The goal of this study was to examine the clinical and haemodynamic outcomes of HT in patients who need MR. Patients and methods: Nine university hospitals in Korea participated in this multicentre study. A total of 134 patients with multilevel PAD underwent HT and MR. Patients were enrolled from July 2014 to June 2015 and were followed for 18 months. Results: The mean age of the patients was 68.8 ± 9.93 years and 88.1 % were men. Patients with Rutherford category 2 to 3 and 4 to 6 comprised 59.0 % and 42.0 % of the group, respectively. The technical success rate was 100 %. The primary patency rates at 12 and 18 months were 77.6 % and 63.9 %, respectively. The primary-assisted patency rates at 12 and 18 months were both 90.0 %. The pre-operative mean ankle brachial index (0.43 ± 0.23) increased to 0.87 ± 0.23 at six months post-operatively (t-test, p < 0.05). The amputation free survival rate was 97.1 %. Conclusions: Although outcomes of multilevel PAD are reportedly poor when endovascular treatment alone is used, we have shown that HT is a feasible alternative modality for patients with multilevel PAD, with satisfactory amputation-free survival and freedom from re-intervention rates.

A Case of Catatonia in a 14-Year-Old Girl with Schizophrenia Treated with Electroconvulsive Therapy

2013 ◽  
Vol 41 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Frank Häßler ◽  
Olaf Reis ◽  
Steffen Weirich ◽  
Jacqueline Höppner ◽  
Birgit Pohl ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Response ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Combined Treatment ◽  
Adolescent Patient

This article presents a case of a 14-year-old female twin with schizophrenia who developed severe catatonia following treatment with olanzapine. Under a combined treatment with amantadine, electroconvulsive therapy (ECT), and (currently) ziprasidone alone she improved markedly. Severity and course of catatonia including treatment response were evaluated with the Bush-Francis Catatonia Rating Scale (BFCRS). This case report emphasizes the benefit of ECT in the treatment of catatonic symptoms in an adolescent patient with schizophrenic illness.

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