Dalbavancin treatment of prosthetic knee infection due to oxacillin-resistant Staphylococcus epidermidis

Here, we present a case of a 79-year-old female with a recalcitrant Staphylococcal epidermidis prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant retention surgery. The bacteriophage used in this case, PM448, is the first ɛ2 bacteriophage to be used in vivo. Currently the patient is without evidence of clinical recurrence and, interestingly, the patient had also suffered from debilitating aplastic anemia for over 2 years, which is recovering since receiving adjuvant bacteriophage therapy.

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Linezolid treatment of total prosthetic knee infection due to methicillin-resistant Staphylococcus epidermidis

Journal of Infection ◽

10.1016/s0163-4453(03)00019-7 ◽

2003 ◽

Vol 47 (1) ◽

pp. 87-88 ◽

Cited By ~ 13

Author(s):

A JOVERSAENZ

Keyword(s):

Staphylococcus Epidermidis ◽

Methicillin Resistant ◽

Knee Infection ◽

Prosthetic Knee ◽

Prosthetic Knee Infection

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Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-020-04982-w ◽

2020 ◽

Author(s):

Jorrit W. A. Schoenmakers ◽

Marjolein Heuker ◽

Marina López-Álvarez ◽

Wouter B. Nagengast ◽

Gooitzen M. van Dam ◽

...

Keyword(s):

Optical Imaging ◽

Bacterial Species ◽

Bacterial Biofilms ◽

Infection Model ◽

Knee Infection ◽

Prosthetic Knee ◽

Image Guided ◽

Prosthetic Joints ◽

Prosthetic Joint Infections ◽

Prosthetic Knee Infection

Abstract Purpose Due to an increased human life expectancy, the need to replace arthritic or dysfunctional joints by prosthetics is higher than ever before. Prosthetic joints are unfortunately inherently susceptible to bacterial infection accompanied by biofilm formation. Accurate and rapid diagnosis is vital to increase therapeutic success. Yet, established diagnostic modalities cannot directly detect bacterial biofilms on prostheses. Therefore, the present study was aimed at investigating whether arthroscopic optical imaging can accurately detect bacterial biofilms on prosthetic joints. Methods Here, we applied a conjugate of the antibiotic vancomycin and the near-infrared fluorophore IRDye800CW, in short vanco-800CW, in combination with arthroscopic optical imaging to target and visualize biofilms on infected prostheses. Results We show in a human post-mortem prosthetic knee infection model that a staphylococcal biofilm is accurately detected in real time and distinguished from sterile sections in high resolution. In addition, we demonstrate that biofilms associated with the clinically most relevant bacterial species can be detected using vanco-800CW. Conclusion The presented image-guided arthroscopic approach provides direct visual diagnostic information and facilitates immediate appropriate treatment selection.

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