Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase

2009 ◽  
Vol 44 (5) ◽  
pp. 1913-1920 ◽  
Author(s):  
Xiaoyun Chai ◽  
Jun Zhang ◽  
Honggang Hu ◽  
Shichong Yu ◽  
Qingyan Sun ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Biological Evaluation of New Indole-Acrylamide-1,2,3-Triazole Derivatives as Potential α-Glucosidase Inhibitors

2020 ◽  
pp. 1-9
Author(s):  
Seyed Esmaeil Sadat-Ebrahimi ◽  
Hiva Babania ◽  
Maryam Mohammadi-Khanaposhtani ◽  
Mohammad Sadegh Asgari ◽  
Somayeh Mojtabavi ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Glucosidase Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 149-159 ◽  
Author(s):  
Gaochan Wu ◽  
Yun Gao ◽  
Dongwei Kang ◽  
Boshi Huang ◽  
Zhipeng Huo ◽  
...  
Keyword(s):  
Cholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Dipolar Cycloaddition ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Design And Synthesis ◽  
Cuaac Reaction ◽  
Synthesis And Biological Evaluation

We report herein the design and synthesis of a series of 11 novel tacrine-1,2,3-triazole derivatives via a Cu(i)-catalyzed alkyne–azide 1,3-dipolar cycloaddition (CuAAC) reaction.

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