Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents

2011 ◽  
Vol 46 (8) ◽  
pp. 3210-3217 ◽  
Author(s):  
Doma Mahendhar Reddy ◽  
Naveed A. Qazi ◽  
Sanghpal D. Sawant ◽  
Abid H. Bandey ◽  
Jada Srinivas ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Anti Cancer ◽  
Spiro Derivatives ◽  
Derivatives Of

Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds

2014 ◽  
Vol 82 ◽  
pp. 255-262 ◽  
Author(s):  
Jabeena Khazir ◽  
Irfan Hyder ◽  
J. Laxmi Gayatri ◽  
Leela Prasad Yandrati ◽  
Naresh Nalla ◽  
...  
Keyword(s):  
Triazole Derivatives ◽  
Design And Synthesis ◽  
Anti Cancer ◽  
Derivatives Of

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

2019 ◽  
Vol 19 (7) ◽  
pp. 842-874 ◽  
Author(s):  
Harbinder Singh ◽  
Nihar Kinarivala ◽  
Sahil Sharma
Keyword(s):  
Anticancer Agents ◽  
Cancer Drug ◽  
Design And Synthesis ◽  
Cancer Drug Discovery ◽  
Dual Targeting ◽  
Structure Activity ◽  
Anti Cancer ◽  
Dual Inhibitors ◽  
Recent Trends ◽  
Synthetic Routes

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

Design and Synthesis of Novel 20(S)-α-aminophosphonate Derivatives of Camptothecin as Potent Antitumor Agents

2021 ◽  
pp. 105065
Author(s):  
Yu-Yuan Chen ◽  
Yin-Peng Bai ◽  
Bin Li ◽  
Xiao-Bo Zhao ◽  
Cheng-Jie Yang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Design And Synthesis ◽  
Derivatives Of

Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing

2021 ◽  
Vol 19 (6) ◽  
pp. 1365-1377
Author(s):  
Arun K. Ghosh ◽  
Srinivasa Rao Allu ◽  
Guddeti Chandrashekar Reddy ◽  
Adriana Gamboa Lopez ◽  
Patricia Mendez ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design And Synthesis ◽  
In Vitro Splicing ◽  
Enantioselective Syntheses ◽  
Derivatives Of

Enantioselective syntheses of C-6 modified derivatives of herboxidiene and their biological evaluation in splicing inhibitory assay.

tert-Amino effect in heterocyclic chemistry. Synthesis of hydrogenated spiro derivatives of quinolines

2004 ◽  
Vol 53 (6) ◽  
pp. 1240-1247 ◽  
Author(s):  
E. V. D"yachenko ◽  
T. V. Glukhareva ◽  
E. F. Nikolaenko ◽  
A. V. Tkachev ◽  
Yu. Yu. Morzherin
Keyword(s):  
Heterocyclic Chemistry ◽  
Spiro Derivatives ◽  
Derivatives Of

Design and synthesis of novel benzimidazoles containing 1,2,3-triazolesas in vitro, anticancer and anti-oxidant agents

2021 ◽  
Vol 25 (11) ◽  
pp. 104-109
Author(s):  
Gullapelli Kumaraswamy ◽  
Ravichandar Maroju ◽  
Srinivas Bandari ◽  
Gouthami Dasari ◽  
Gullapelli Sadanandam
Keyword(s):  
Spectroscopic Methods ◽  
Moderate Activity ◽  
Design And Synthesis ◽  
Anti Cancer ◽  
Excellent Activity ◽  
Test Organisms ◽  
Anti Oxidant ◽  
High Yields ◽  
Cancer Activity

A novel series of 2-(1-((1-substitutedphenyl-1H-1,2,3- triazol-4-yl)methoxy)ethyl)-1-((1-substituted phenyl- 1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazole (3a-j)derivatives was synthesized in moderate to high yields. The structures of all the synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopic methods. The title compounds were screened for their anti-oxidant activity and anti-cancer activity. The cancer activity results reveal that the compounds 3j, 3b and 3f are showing promising activity and remaining compounds exhibited moderate activity against all the tested cancer cell lines. The anti-oxidant activity also shows that the compounds 3c and 3d have shown excellent activity and remaining compounds were also found to exhibit moderate activity against the test organisms employed.

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