Design and Synthesis of Amide Derivatives of Melampomagnolamine: Acted as Potent Anti-cancer Agents

2016 ◽  
Author(s):  
Venumadhav Janganati
Keyword(s):  
Design And Synthesis ◽  
Amide Derivatives ◽  
Anti Cancer ◽  
Derivatives Of

Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents

2011 ◽  
Vol 46 (8) ◽  
pp. 3210-3217 ◽  
Author(s):  
Doma Mahendhar Reddy ◽  
Naveed A. Qazi ◽  
Sanghpal D. Sawant ◽  
Abid H. Bandey ◽  
Jada Srinivas ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Anti Cancer ◽  
Spiro Derivatives ◽  
Derivatives Of

Design and Synthesis of Some Novel Aromatic Amide Derivatives of Nilutamide as In Vitro Anticancer Agents

2020 ◽  
Vol 5 (39) ◽  
pp. 12317-12319
Author(s):  
Narasimha Swamy Thirukovela ◽  
Satheesh Kumar Nukala ◽  
Narsimha Sirassu ◽  
Ravinder Manchal ◽  
Prasad Gundepaka ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis ◽  
Amide Derivatives ◽  
Aromatic Amide ◽  
Derivatives Of

Structural Modification of Sylibin to Derivatives of Sylibin/Hydnocarpin D /Silandrin, and Evaluation of Their Cytotoxicity Against Cancer Cells

2021 ◽  
Vol 21 ◽  
Author(s):  
Liwaliding Maihesuti ◽  
Hongwei Gao ◽  
Qi Wang ◽  
Jianguo Cao ◽  
Haji Akber Aisa ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cancer Cells ◽  
Chemical Conversion ◽  
Molecular Iodine ◽  
Inhibitory Effect ◽  
Mtt Method ◽  
Amide Derivatives ◽  
Anti Cancer ◽  
Related Proteins ◽  
Derivatives Of

Background: Flavonolignans like silybin, hydnocarpin, and siliandrin are a group of natural compounds combining the structural moieties of flavonoid and phenylpropanoid (lignan). Hydnocarpin and silandrin were less explored because of trace occurrence in nature. Objective: The present study aimed to develop a chemical conversion of silybin to hydnocarpin, and siliandrin. Also, a series of amide derivatives would be synthesized and biologically evaluated with regard to their anti-cancer effects. Methods: In order to selectively convert silybin to 23-iodo silybin, 23-iodo hydnocarpin D and 23-iodo isosilandrin, the ratio of Ph3P, imidazole and molecular iodine was meticulously adjusted. These three iodide compounds were converted into amide compounds by chemical transformation. MTT method was applied to evaluate their anti-cancer potency. The binding affinity to related proteins was calculated by molecular docking. Results: Totally, 45 new amido-derivatives were synthesized and structurally characterized by NMR and HRMS. Some of them showed moderate to good antiproliferative potency against cancer cells. The activity of compound 10j was further testified by colony formation assay and molecular docking. Conclusion: Synthesis of 23-iodo silybin, 23-iodo hydnocarpin D and 23-iodo isosilandrin from silybin was successfully accomplished by one simple iodination reaction. Some of the amide derivatives of sylibin/hydnocarpin D /silandrin exhibit a remarkable inhibitory effect of proliferation on cancer cells as compared to silybin. These results would pave the way for further investigation on the derivatives of flavonolignans for the treatment of cancer.

Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds

2014 ◽  
Vol 82 ◽  
pp. 255-262 ◽  
Author(s):  
Jabeena Khazir ◽  
Irfan Hyder ◽  
J. Laxmi Gayatri ◽  
Leela Prasad Yandrati ◽  
Naresh Nalla ◽  
...  
Keyword(s):  
Triazole Derivatives ◽  
Design And Synthesis ◽  
Anti Cancer ◽  
Derivatives Of

Synthesis and Biological Activity of 28-Amide Derivatives of 23-Hydroxy Betulinic Acid as Antitumor Agent Candidates

2013 ◽  
Vol 9 (7) ◽  
pp. 920-925 ◽  
Author(s):  
Yi Bi ◽  
Jinyi Xu ◽  
Fei Sun ◽  
Xiaoming Wu ◽  
Wencai Ye ◽  
...  
Keyword(s):  
Biological Activity ◽  
Betulinic Acid ◽  
Antitumor Agent ◽  
Amide Derivatives ◽  
Derivatives Of

Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

2020 ◽  
Vol 20 ◽  
Author(s):  
Vasil Tsanov ◽  
Hristo Tsanov
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Quantum Chemical ◽  
Density Functional ◽  
Enzyme Regulation ◽  
Amide Derivatives ◽  
Pass Through ◽  
Hydrolysis Of ◽  
Derivatives Of

Background:: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semi-empirical methods, is considered. Objective:: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and / or modified forms to counteract "external" bioactive activity. Cancers, for their part, have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops according to its instructions. Methods:: Derived pedestal that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent density-functional quantum- chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to forms causing chemical apoptosis of the cell - independent of its non-genetic set, which seeks to counteract the process. Results:: Used in oncology it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). Conclusion:: The amide derivatives of nitrile glycosides exhibit anti-cancer activity, the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide- carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and / or permanently damage its normal physiology.

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

2019 ◽  
Vol 19 (7) ◽  
pp. 842-874 ◽  
Author(s):  
Harbinder Singh ◽  
Nihar Kinarivala ◽  
Sahil Sharma
Keyword(s):  
Anticancer Agents ◽  
Cancer Drug ◽  
Design And Synthesis ◽  
Cancer Drug Discovery ◽  
Dual Targeting ◽  
Structure Activity ◽  
Anti Cancer ◽  
Dual Inhibitors ◽  
Recent Trends ◽  
Synthetic Routes

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

Design and Synthesis of Novel β-Carboline Linked Amide Derivatives as Anticancer Agents

2019 ◽  
Vol 89 (3) ◽  
pp. 511-516 ◽  
Author(s):  
B. Ravinaik ◽  
D. Ramachandran ◽  
M. V. Basaveswara Rao
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis ◽  
Amide Derivatives

scholarly journals Amide Derivatives of Ginkgolide B and Their Inhibitory Effects on PAF-Induced Platelet Aggregation

ACS Omega ◽  
2021 ◽  
Author(s):  
Qiang Shang ◽  
Xiaobo Zhou ◽  
Ming-Rong Yang ◽  
Jing-Guang Lu ◽  
Yu Pan ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Ginkgolide B ◽  
Inhibitory Effects ◽  
Amide Derivatives ◽  
Derivatives Of

Design and Synthesis of Novel 20(S)-α-aminophosphonate Derivatives of Camptothecin as Potent Antitumor Agents

2021 ◽  
pp. 105065
Author(s):  
Yu-Yuan Chen ◽  
Yin-Peng Bai ◽  
Bin Li ◽  
Xiao-Bo Zhao ◽  
Cheng-Jie Yang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Design And Synthesis ◽  
Derivatives Of
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