ChemInform Abstract: Design and Synthesis of Spiro Derivatives of Parthenin as Novel Anticancer Agents.

ChemInform ◽  
2011 ◽  
Vol 42 (44) ◽  
pp. no-no
Author(s):  
H. M. Sampath Kumar ◽  
et al. et al.
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis ◽  
Spiro Derivatives ◽  
Derivatives Of

Design and Synthesis of Novel Urea Derivatives of Pyrimidine-Pyrazoles as Anticancer Agents

2021 ◽  
pp. 131937
Author(s):  
Purna Koteswara Rao Cherukumalli ◽  
Bhaskara Rao Tadiboina ◽  
Kali Charan Gulipalli ◽  
Srinu Bodige ◽  
Vishnu Nayak Badavath ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Urea Derivatives ◽  
Design And Synthesis ◽  
Derivatives Of

Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents

2011 ◽  
Vol 46 (8) ◽  
pp. 3210-3217 ◽  
Author(s):  
Doma Mahendhar Reddy ◽  
Naveed A. Qazi ◽  
Sanghpal D. Sawant ◽  
Abid H. Bandey ◽  
Jada Srinivas ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Anti Cancer ◽  
Spiro Derivatives ◽  
Derivatives Of

Design and Synthesis of Some Novel Aromatic Amide Derivatives of Nilutamide as In Vitro Anticancer Agents

2020 ◽  
Vol 5 (39) ◽  
pp. 12317-12319
Author(s):  
Narasimha Swamy Thirukovela ◽  
Satheesh Kumar Nukala ◽  
Narsimha Sirassu ◽  
Ravinder Manchal ◽  
Prasad Gundepaka ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis ◽  
Amide Derivatives ◽  
Aromatic Amide ◽  
Derivatives Of

Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking

2019 ◽  
Vol 19 (4) ◽  
pp. 439-452 ◽  
Author(s):  
Mohamed R. Selim ◽  
Medhat A. Zahran ◽  
Amany Belal ◽  
Moustafa S. Abusaif ◽  
Said A. Shedid ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Agents ◽  
Caspase 3 ◽  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Design Synthesis ◽  
Chemical Structures ◽  
M Phase ◽  
Induced Apoptosis ◽  
Derivatives Of

Objective: Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. Methods: Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine derivatives 16a-c were synthesized. Their chemical structures were characterized through spectral and elemental analysis, cytotoxic activity on five cancer cell lines, caspase-3 activation, tubulin polymerization inhibition and cell cycle analysis were evaluated. Results: Four compounds 3b, 3d, 8 and 13 showed potent activity than doxorubicin on HCT116 and three compounds 3b, 3d and 8 on HEPG2. These promising derivatives showed increase in the level of caspase-3. The trifloromethylphenyl derivatives of pyrazolopyrimidoquinolines 3b and 3d showed considerable tubulin polymerization inhibitory activity. Both compounds arrested cell cycle at G2/M phase and induced apoptosis. Conclusion: Compounds 3b and 3d can be considered as promising anticancer active agents with 70% of colchicine activity on tubulin polymerization inhibition and represent hopeful leads that deserve further investigation and optimization.

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

2019 ◽  
Vol 19 (7) ◽  
pp. 842-874 ◽  
Author(s):  
Harbinder Singh ◽  
Nihar Kinarivala ◽  
Sahil Sharma
Keyword(s):  
Anticancer Agents ◽  
Cancer Drug ◽  
Design And Synthesis ◽  
Cancer Drug Discovery ◽  
Dual Targeting ◽  
Structure Activity ◽  
Anti Cancer ◽  
Dual Inhibitors ◽  
Recent Trends ◽  
Synthetic Routes

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

Design and Synthesis of Novel β-Carboline Linked Amide Derivatives as Anticancer Agents

2019 ◽  
Vol 89 (3) ◽  
pp. 511-516 ◽  
Author(s):  
B. Ravinaik ◽  
D. Ramachandran ◽  
M. V. Basaveswara Rao
Keyword(s):  
Anticancer Agents ◽  
Design And Synthesis ◽  
Amide Derivatives

scholarly journals Spiro Derivatives of Cyclic Betaines. Synthesis and Structure of Spiro Derivatives of Isoxazolium and Pyrazolium Olates

1999 ◽  
Vol 23 (1) ◽  
pp. xii-xiii
Author(s):  
Gury Zvilichovsky ◽  
Vadim Gurvich ◽  
Shmuel Cohen
Keyword(s):  
Spiro Derivatives ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document