Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists

Biological Evaluation ◽

Nicotinic Acetylcholine ◽

Partial Agonists ◽

Design, synthesis and biological evaluation of 1,4-Diazobicylco[3.2.2]nonane derivatives as α7-Nicotinic acetylcholine receptor PET/CT imaging agents and agonists for Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.09.064 ◽

2018 ◽

Vol 159 ◽

pp. 255-266 ◽

Cited By ~ 2

Author(s):

Shuxia Wang ◽

Yu Fang ◽

Huan Wang ◽

Hang Gao ◽

Guohua Jiang ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Biological Evaluation ◽

Ct Imaging ◽

Imaging Agents ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Pet Ct ◽

Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm4013592 ◽

2013 ◽

Vol 56 (23) ◽

pp. 9673-9682 ◽

Cited By ~ 32

Author(s):

François Crestey ◽

Anders A. Jensen ◽

Morten Borch ◽

Jesper Tobias Andreasen ◽

Jacob Andersen ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Biological Evaluation ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Antagonists ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Erythrina Alkaloid

Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01767 ◽

2022 ◽

Author(s):

Mark Montgomery ◽

Stefano Rendine ◽

Christoph T. Zimmer ◽

Jan Elias ◽

Jürgen Schaetzer ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Structural Biology ◽

Biological Evaluation ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Synthesis and biological evaluation of 9-fluorenone derivatives for SPECT imaging of α7-nicotinic acetylcholine receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.126724 ◽

2019 ◽

Vol 29 (23) ◽

pp. 126724

Author(s):

Hang Gao ◽

Shuxia Wang ◽

Yueheng Qi ◽

Guoxue He ◽

Bingchao Qiang ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Biological Evaluation ◽

Spect Imaging ◽

Nicotinic Acetylcholine ◽

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

The EMBO Journal ◽

10.1038/emboj.2009.227 ◽

2009 ◽

Vol 28 (19) ◽

pp. 3040-3051 ◽

Cited By ~ 119

Author(s):

Ryan E Hibbs ◽

Gerlind Sulzenbacher ◽

Jianxin Shi ◽

Todd T Talley ◽

Sandrine Conrod ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Binding Protein ◽

Structural Determinants ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein ◽

Electrophysiological Perspectives on the Therapeutic Use of Nicotinic Acetylcholine Receptor Partial Agonists

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.177485 ◽

2011 ◽

Vol 337 (2) ◽

pp. 367-379 ◽

Cited By ~ 43

Author(s):

Roger L. Papke ◽

Caryn Trocmé-Thibierge ◽

Daniela Guendisch ◽

Shehd Abdullah Abbas Al Rubaiy ◽

Stephen A. Bloom

Keyword(s):

Acetylcholine Receptor ◽

Therapeutic Use ◽

Nicotinic Acetylcholine ◽

Partial Agonists of the α3β4* Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

Neuropsychopharmacology ◽

10.1038/npp.2010.191 ◽

2010 ◽

Vol 36 (3) ◽

pp. 603-615 ◽

Cited By ~ 83

Author(s):

Susmita Chatterjee ◽

Pia Steensland ◽

Jeffrey A Simms ◽

Joan Holgate ◽

Jotham W Coe ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Ethanol Consumption ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor

Journal of Molecular Modeling ◽

10.1007/s00894-017-3419-4 ◽

2017 ◽

Vol 23 (9) ◽

Cited By ~ 3

Author(s):

Nargis Tabassum ◽

Qianyun Ma ◽

Guanzhao Wu ◽

Tao Jiang ◽

Rilei Yu

Keyword(s):

Binding Energy ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Partial Agonists ◽

Energy Profiles

Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2010.00682.x ◽

2010 ◽

Vol 160 (2) ◽

pp. 334-345 ◽

Cited By ~ 111

Author(s):

H Rollema ◽

A Shrikhande ◽

KM Ward ◽

FD Tingley III ◽

JW Coe ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotine Dependence ◽

Clinical Efficacy ◽

Nicotinic Acetylcholine ◽

Chemistry and Pharmacological Characterization of Novel Nitrogen Analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-Nicotinic Acetylcholine Receptor-Selective Partial Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm100765u ◽

2010 ◽

Vol 53 (19) ◽

pp. 6973-6985 ◽

Cited By ~ 18

Author(s):

Jianhua Liu ◽

J. Brek Eaton ◽

Barbara Caldarone ◽

Ronald J. Lukas ◽

Alan P. Kozikowski

Keyword(s):

Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Nicotinic Acetylcholine ◽

Partial Agonists ◽

Nitrogen Analogues