Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor

Nargis Tabassum; Qianyun Ma; Guanzhao Wu; Tao Jiang; Rilei Yu

doi:10.1007/s00894-017-3419-4

Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor

Journal of Molecular Modeling ◽

10.1007/s00894-017-3419-4 ◽

2017 ◽

Vol 23 (9) ◽

Cited By ~ 3

Author(s):

Nargis Tabassum ◽

Qianyun Ma ◽

Guanzhao Wu ◽

Tao Jiang ◽

Rilei Yu

Keyword(s):

Binding Energy ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Partial Agonists ◽

Energy Profiles

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Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

The EMBO Journal ◽

10.1038/emboj.2009.227 ◽

2009 ◽

Vol 28 (19) ◽

pp. 3040-3051 ◽

Cited By ~ 119

Author(s):

Ryan E Hibbs ◽

Gerlind Sulzenbacher ◽

Jianxin Shi ◽

Todd T Talley ◽

Sandrine Conrod ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Structural Determinants ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein ◽

Partial Agonists

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Activation of α7 nicotinic acetylcholine receptor alleviates cerebral cortical neuron injury induced by oxygen-glucose deprivation

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2015.00472 ◽

2015 ◽

Vol 36 (5) ◽

pp. 472

Author(s):

Ru-juan XIN ◽

Ting ZHAO ◽

Min NI ◽

Dong-jie LI ◽

Fu-ming SHEN

Keyword(s):

Cortical Neuron ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Glucose Deprivation ◽

Oxygen Glucose Deprivation ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Cerebral Cortical Neuron ◽

Neuron Injury

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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Retracted : Role of α7‐nicotinic acetylcholine receptor in human non‐small cell lung cancer proliferation

Cell Proliferation ◽

10.1111/j.1365-2184.2008.00566.x ◽

2008 ◽

Vol 41 (6) ◽

pp. 936-959 ◽

Cited By ~ 57

Author(s):

L. Paleari ◽

A. Catassi ◽

M. Ciarlo ◽

Z. Cavalieri ◽

C. Bruzzo ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Small Cell ◽

Small Cell Lung ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Cancer Proliferation ◽

Nicotinic Acetylcholine

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Nicotine Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.116.307264 ◽

2017 ◽

Vol 37 (1) ◽

pp. 53-65 ◽

Cited By ~ 27

Author(s):

Chen Wang ◽

Han Chen ◽

Wei Zhu ◽

Yinchuan Xu ◽

Mingfei Liu ◽

...

Keyword(s):

Mast Cells ◽

Apolipoprotein E ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Deficient Mice

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Serotonin antagonizes the human neuronal α7 nicotinic acetylcholine receptor and becomes an agonist after L248T α7 mutation

Neuroscience ◽

10.1016/s0306-4522(01)00567-x ◽

2002 ◽

Vol 110 (1) ◽

pp. 169-179 ◽

Cited By ~ 14

Author(s):

S Fucile ◽

E Palma ◽

F Eusebi ◽

R Miledi

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the α7 nicotinic acetylcholine receptor

Brain Research ◽

10.1016/j.brainres.2016.04.043 ◽

2016 ◽

Vol 1642 ◽

pp. 487-496 ◽

Cited By ~ 18

Author(s):

Xiaolan Li ◽

Xinjia Han ◽

Junjie Bao ◽

Yuanyuan Liu ◽

Aihua Ye ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Rat Hippocampus ◽

Seizure Threshold ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal

Psychopharmacology ◽

10.1007/s00213-018-4879-7 ◽

2018 ◽

Vol 235 (7) ◽

pp. 1897-1905 ◽

Cited By ~ 10

Author(s):

Asti Jackson ◽

Roger L. Papke ◽

M. Imad Damaj

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotine Withdrawal ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Pharmacological Modulation

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Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

Journal of Neuroimmune Pharmacology ◽

10.1007/s11481-015-9601-5 ◽

2015 ◽

Vol 10 (3) ◽

pp. 468-476 ◽

Cited By ~ 81

Author(s):

Carlos A. Báez-Pagán ◽

Manuel Delgado-Vélez ◽

José A. Lasalde-Dominicci

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

And Control

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APN1125: A clinical stage α7 nicotinic acetylcholine receptor partial agonist

Biochemical Pharmacology ◽

10.1016/j.bcp.2015.08.042 ◽

2015 ◽

Vol 97 (4) ◽

pp. 636 ◽

Cited By ~ 1

Author(s):

Gerald Koelsch ◽

Michael J. Detke ◽

Karen E. Stevens ◽

Leonard T. Meltzer ◽

Alvin V. Terry ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Clinical Stage ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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