scholarly journals Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes

2017 ◽  
Vol 136 ◽  
pp. 548-560 ◽  
Author(s):  
Jianrong Liu ◽  
Aurélie Maisonial-Besset ◽  
Barbara Wenzel ◽  
Damien Canitrot ◽  
Ariane Baufond ◽  
...  
Keyword(s):  
Quinoline Derivatives ◽  
In Vitro Evaluation ◽  
High Affinity

Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1′-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors

1999 ◽  
Vol 26 (7) ◽  
pp. 725-735 ◽  
Author(s):  
Bingzhi Shi ◽  
Tanjore K Narayanan ◽  
Zhi-Ying Yang ◽  
Bradley T Christian ◽  
Jogeshwar Mukherjee
Keyword(s):  
In Vitro Evaluation ◽  
High Affinity ◽  
D 2 Receptors

Synthesis and in vitro evaluation of 18F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET

2010 ◽  
Vol 20 (5) ◽  
pp. 1749-1751 ◽  
Author(s):  
Edward G. Robins ◽  
Yongjun Zhao ◽  
Imtiaz Khan ◽  
Anthony Wilson ◽  
Sajinder K. Luthra ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
In Vitro Evaluation ◽  
High Affinity

Syntheses and in vitro evaluation of water-soluble "cationic metalloporphyrin-ellipticine" molecules having a high affinity for DNA

1991 ◽  
Vol 34 (3) ◽  
pp. 900-906 ◽  
Author(s):  
Li Ding ◽  
Guita Etemad-Moghadam ◽  
Suzy Cros ◽  
Christian Auclair ◽  
Bernard Meunier
Keyword(s):  
Water Soluble ◽  
In Vitro Evaluation ◽  
High Affinity

scholarly journals Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 203 ◽  
Author(s):  
Ying Lin ◽  
Dong Xing ◽  
Wen-Biao Wu ◽  
Gao-Ya Xu ◽  
Li-Fang Yu ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
Reaction Conditions ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Metal Free ◽  
Sequential Transformation ◽  
High Yields

Herein, we design and synthesize an array of benzofuro[3,2-c]quinolines starting from 3-(2-methoxyphenyl)quinolin-4(1H)ones via a sequential chlorination/demethylation, intramolecular cyclization pathway. This sequential transformation was efficient, conducted under metal-free and mild reaction conditions, and yielded corresponding benzofuro[3,2-c]quinolines in high yields. In vitro biological evaluation indicated that such type of compounds showed excellent antileukemia activity and selectivity, and therefore may offer a promising hit compound for developing antileukemia compounds.

Synthesis and in Vitro Evaluation of Biotinylated RG108:  A High Affinity Compound for Studying Binding Interactions with Human DNA Methyltransferases

2006 ◽  
Vol 17 (2) ◽  
pp. 261-266 ◽  
Author(s):  
Esther Schirrmacher ◽  
Carmen Beck ◽  
Bodo Brueckner ◽  
Frank Schmitges ◽  
Pawel Siedlecki ◽  
...  
Keyword(s):  
Dna Methyltransferases ◽  
Binding Interactions ◽  
In Vitro Evaluation ◽  
High Affinity ◽  
Human Dna

Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled .sigma. binding site

1993 ◽  
Vol 36 (3) ◽  
pp. 343-352 ◽  
Author(s):  
Richard E. Mewshaw ◽  
Ronald G. Sherrill ◽  
Rose M. Mathew ◽  
Carl Kaiser ◽  
Michael A. Bailey ◽  
...  
Keyword(s):  
Binding Site ◽  
In Vitro Evaluation ◽  
Affinity Ligands ◽  
High Affinity

scholarly journals Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

2016 ◽  
Vol 10 ◽  
Author(s):  
Muneer Ahamed ◽  
Daisy van Veghel ◽  
Christoph Ullmer ◽  
Koen Van Laere ◽  
Alfons Verbruggen ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
In Vitro Evaluation ◽  
Receptor Agonists ◽  
High Affinity

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors

1991 ◽  
Vol 34 (5) ◽  
pp. 1612-1624 ◽  
Author(s):  
John E. Bishop ◽  
Chester A. Mathis ◽  
John M. Gerdes ◽  
John M. Whitney ◽  
Allison M. Eaton ◽  
...  
Keyword(s):  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
In Vitro Evaluation ◽  
Affinity Ligands ◽  
High Affinity ◽  
Dopamine D2 ◽  
Substituted Benzamides
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