Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

2018 ◽  
Vol 143 ◽  
pp. 361-375 ◽  
Author(s):  
Lingfeng Chen ◽  
Yiyi Jin ◽  
Hongjin Chen ◽  
Chuchu Sun ◽  
Weitao Fu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Myeloid Differentiation

Chelidonine Attenuates Sepsis-Induced Acute Lung Injury via Suppressing Toll-like Receptor 4/Myeloid Differentiation Factor 88/Nuclear Factor-॔B Signaling Pathway in Newborn Mice

2020 ◽  
Vol 19 (1) ◽  
pp. 120-126
Author(s):  
Ayinuerguli Adili ◽  
Adilijiang Kari ◽  
Chuanlong Song ◽  
Abulaiti Abuduhaer
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Nuclear Factor Kappa B ◽  
Myeloid Differentiation ◽  
Nuclear Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Infiltration ◽  
Newborn Mice ◽  
Myeloid Differentiation Factor

We have examined the mechanism underlying amelioration of sepsis-induced acute lung injury by chelidonine in newborn mice. To this end, a sepsis model was established using cecal ligation and puncture in newborn mice. The sepsis-induced acute lung injury was associated with an increased inflammatory infiltration and pulmonary congestion, as well as abnormal alveolar morphology. The lung injury-associated increased tumor necrosis factor-α and interleukin-1β in bronchoalveolar lavage fluid and lung, the markers of inflammatory infiltration and pulmonary congestion, diminished by chelidonine treatment. Chelidonine administration also downregulated protein levels of toll-like receptor 4, myeloid differentiation factor 88, phosphorylated nuclear factor-kappa B, and nuclear factor-kappa B that are elevated in response to sepsis. In conclusion, chelidonine provides a potential therapeutic strategy for newborn mice with acute lung injury.

Bilobalide Ameliorates Sepsis Induced Acute Lung Injury by Inactivating Toll-Like Receptor 4/Myeloid Differentiation Factor 88/Nuclear Factor-Kappa B Pathway

2020 ◽  
Vol 19 (3) ◽  
pp. 277-282
Author(s):  
Tian Liu ◽  
Siyi Jiang ◽  
Shengwei Jia ◽  
Fuxiang Fan
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Nuclear Factor Kappa B ◽  
Cecal Ligation ◽  
Myeloid Differentiation ◽  
Nuclear Factor ◽  
Cecal Ligation And Puncture ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Myeloid Differentiation Factor

Acute lung injury refers to the injury of alveolar epithelial cells and pulmonary capillary endothelial cells caused by noncardiac factors. To better combat the disease, there is an urgent need to develop more effective drugs. Sepsis is a syndrome of systemic inflammation caused by infection, and the molecular mechanism by which sepsis induces acute lung injury has not been clearly determined. Bilobalide is a unique component of Ginkgo biloba. Although it has multiple biological functions, its role in sepsis induced acute lung injury needs further study. In this study, we found that bilobalide alleviated cecal ligation and puncture induced acute lung injury. Additionally, bilobalide regulated cecal ligation and puncture induced lung injury through toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway. We therefore conclude that bilobalide may be a potential drug for the treatment of sepsis induced acute lung injury.

scholarly journals Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury

2016 ◽  
Vol 21 (4) ◽  
pp. 746-757 ◽  
Author(s):  
Yali Zhang ◽  
Tingting Xu ◽  
Beibei Wu ◽  
Hongjin Chen ◽  
Zheer Pan ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Myeloid Differentiation

The Protective Effects of Caffeic Acid Phenethyl Ester on Acetylsalicylic Acid-induced Lung Injury in Rats

2016 ◽  
Vol 29 (6) ◽  
pp. 328-334 ◽  
Author(s):  
Mahşuk Taylan ◽  
Halide Kaya ◽  
Melike Demir ◽  
Osman Evliyaoğlu ◽  
Hadice Selimoglu Sen ◽  
...  
Keyword(s):  
Lung Injury ◽  
Acetylsalicylic Acid ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Effects

OLEIC ACID-INDUCED LUNG INJURY IN RATS AND EFFECTS OF CAFFEIC ACID PHENETHYL ESTER

2005 ◽  
Vol 31 (5) ◽  
pp. 483-496 ◽  
Author(s):  
Oguz Koksel ◽  
Murat Bayram Kaplan ◽  
Ali Ozdulger ◽  
Lulufer Tamer ◽  
Ulas Degirmenci ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats

2007 ◽  
Vol 35 (12) ◽  
pp. 2822-2829 ◽  
Author(s):  
Huseyin Fidan ◽  
Onder Sahin ◽  
Yucel Yavuz ◽  
Aynur Kilbas ◽  
Zafer Cetinkaya ◽  
...  
Keyword(s):  
Lung Injury ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats

2008 ◽  
Vol 31 (5) ◽  
pp. 242 ◽  
Author(s):  
Oguz Galip Yildiz ◽  
Serdar Soyuer ◽  
Recep Saraymen ◽  
Celalettin Eroglu
Keyword(s):  
Radiation Therapy ◽  
Lung Injury ◽  
Caffeic Acid ◽  
Radiation Treatment ◽  
Caffeic Acid Phenethyl Ester ◽  
Albino Rats ◽  
Protective Effects ◽  
Sod Activity ◽  
Radiation Induced

Purpose: The prevention of radiation-induced pulmonary toxicity may help to improve radiation therapy in the cancer patient. The aim of this study was to investigate the pulmonary protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant, on radiation-induced lung injury in rats. Methods:30 Wistar albino rats were divided into three groups and treated with saline, Radiation (RT) and RT + CAPE respectively. All rats were treated with CAPE (50 ?mol/kg i.p.) or saline. The first dose of CAPE was injected 24 h before radiation and application continued daily, with radiation in second day and 2 days more after the radiation treatment. Radiation dose was 800 cGy for total body. At 72 hr after the last radiation application, under general anesthesia using ip ketamine, the lungs were removed immediately after decapitation. After sacrification, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) activities and malondiadehyde (MDA) levels were evaluated in lung tissue. Results: The level of malondialdehyde (MDA) was higher in the RT group (233.4±1.5 nmol/g protein) than in both the control (131.8±0.92) and the RT + CAPE (151.4±1.8) groups (P < 0.001). However, CAT activity was decreased in the RT group (7.26±0.27 Umg protein) compared with control (8.49±0.51) and increased again in the RT + CAPE group (8.31±0.56; P < 0.001). In accord with CAT activity, SOD activity in the RT group (0.42±0.07 nmolMDA/g wet tissue) was different from the control (0.78±0.02) and RT + CAPE (0.86±0.06) groups (P < 0.001). Conclusion: CAPE aplication with radiation therapy attenuated radiation induced pulmonary injury in vivo, possibly by its antioxidant effect.

scholarly journals Shikonin inhibits myeloid differentiation protein 2 to prevent LPS-induced acute lung injury

2018 ◽  
Vol 175 (5) ◽  
pp. 840-854 ◽  
Author(s):  
Yali Zhang ◽  
Tingting Xu ◽  
Zheer Pan ◽  
Xiangting Ge ◽  
Chuchu Sun ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Myeloid Differentiation
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