Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.04.054 ◽

2019 ◽

Vol 174 ◽

pp. 277-291 ◽

Cited By ~ 4

Author(s):

Shuang-Xi Gu ◽

Ting Xiao ◽

Yuan-Yuan Zhu ◽

Gen-Yan Liu ◽

Fen-Er Chen

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Recent Progress ◽

Binding Pocket ◽

Transcriptase Inhibitor ◽

Entrance Channel ◽

Inhibitor Binding ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.113051 ◽

2020 ◽

pp. 113051

Author(s):

Xiangyi Jiang ◽

Boshi Huang ◽

Fisayo A. Olotu ◽

Jing Li ◽

Dongwei Kang ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Binding Pocket ◽

Transcriptase Inhibitor ◽

Region I ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Impact of Residues in the Nonnucleoside Reverse Transcriptase Inhibitor Binding Pocket on HIV-1 Reverse Transcriptase Heterodimer Stability

Current HIV Research ◽

10.2174/157016208783885065 ◽

2008 ◽

Vol 6 (2) ◽

pp. 130-137 ◽

Cited By ~ 16

Author(s):

Anna Figueiredo ◽

Shannon Zelina ◽

Nicolas Sluis-Cremer ◽

Gilda Tachedjian

Keyword(s):

Reverse Transcriptase ◽

Binding Pocket ◽

Transcriptase Inhibitor ◽

Inhibitor Binding ◽

Nonnucleoside Reverse Transcriptase Inhibitor ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01729 ◽

2019 ◽

Vol 62 (4) ◽

pp. 2083-2098 ◽

Cited By ~ 22

Author(s):

Boshi Huang ◽

Wenmin Chen ◽

Tong Zhao ◽

Zhenyu Li ◽

Xiangyi Jiang ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Water Solubility ◽

Binding Pocket ◽

Transcriptase Inhibitor ◽

Wild Type ◽

Region I ◽

Favorable Safety ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Mutational Analysis of Tyr-318 within the Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket of Human Immunodeficiency Virus Type I Reverse Transcriptase

Journal of Biological Chemistry ◽

10.1074/jbc.273.51.34234 ◽

1998 ◽

Vol 273 (51) ◽

pp. 34234-34239 ◽

Cited By ~ 20

Author(s):

Heidi Pelemans ◽

Robert M. Esnouf ◽

Heidi Jonckheere ◽

Erik De Clercq ◽

Jan Balzarini

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Mutational Analysis ◽

Binding Pocket ◽

Transcriptase Inhibitor ◽

Type I ◽

Inhibitor Binding ◽

Immunodeficiency Virus ◽

Reverse Transcriptase Inhibitor

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Faculty Opinions recommendation of Detection of low-level K65R variants in nucleoside reverse transcriptase inhibitor-naive chronic and acute HIV-1 subtype C infections.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12019956.13157054 ◽

2011 ◽

Author(s):

Mark Wainberg ◽

Dimitrios Coutsinos

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Subtype C ◽

Low Level ◽

Acute Hiv ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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A Nanoparticle-Encapsulated Non-Nucleoside Reverse-Transcriptase Inhibitor with Enhanced Anti-HIV-1 Activity and Prolonged Circulation Time in Plasma

Current Pharmaceutical Design ◽

10.2174/1381612820666141014125213 ◽

2014 ◽

Vol 21 (7) ◽

pp. 925-935 ◽

Cited By ~ 11

Author(s):

Wen Li ◽

Qian Wang ◽

Yuan Li ◽

Fei Yu ◽

Qi Liu ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Circulation Time ◽

Reverse Transcriptase Inhibitor ◽

Anti Hiv ◽

Hiv 1

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Virologic Outcome After Switching From a Nucleoside Reverse Transcriptase Inhibitor to Tenofovir in Patients With Undetectable HIV-1 RNA Plasma Level

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/00126334-200407010-00016 ◽

2004 ◽

Vol 36 (3) ◽

pp. 876-878 ◽

Cited By ~ 1

Author(s):

Marc Wirden ◽

Anne Geneviève Marcelin ◽

Roland Tubiana ◽

Marc Antoine Valantin ◽

Jade Ghosn ◽

...

Keyword(s):

Plasma Level ◽

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Efficacy and safety of nucleoside reverse transcriptase inhibitor-sparing salvage therapy for multidrug-resistant HIV-1 infection based on new-class and new-generation antiretrovirals

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkq432 ◽

2010 ◽

Vol 66 (2) ◽

pp. 358-362 ◽

Cited By ~ 14

Author(s):

A. Imaz ◽

J. M. Llibre ◽

M. Mora ◽

G. Mateo ◽

A. Camacho ◽

...

Keyword(s):

Reverse Transcriptase ◽

Salvage Therapy ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Multidrug Resistant ◽

Efficacy And Safety ◽

New Class ◽

New Generation ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Rilpivirine, a Non-Nucleoside Reverse Transcriptase Inhibitor to Treat HIV-1

Analogue-Based Drug Discovery II ◽

10.1002/9783527630035.ch17 ◽

2010 ◽

pp. 409-441

Author(s):

Jerome Guillemont ◽

Luc Geeraert ◽

Jan Heeres ◽

Paul J. Lewi

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Transcriptase Inhibitor ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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Combined Analysis of Two-Year Follow-Up from Two Open-Label Randomized Trials Comparing Efficacy of Three Nucleoside Reverse Transcriptase Inhibitor Backbones for Previously Untreated HIV-1 Infection: OzCombo 1 and 2

HIV Clinical Trials ◽

10.1310/k2u9-qc2v-1y3v-5dyf ◽

2003 ◽

Vol 4 (4) ◽

pp. 252-261 ◽

Cited By ~ 19

Author(s):

J Amin ◽

A. Moore ◽

A Carr ◽

M.A. French ◽

M Law ◽

...

Keyword(s):

Reverse Transcriptase ◽

Nucleoside Reverse Transcriptase Inhibitor ◽

Randomized Trials ◽

Transcriptase Inhibitor ◽

Open Label ◽

Combined Analysis ◽

Reverse Transcriptase Inhibitor ◽

Hiv 1

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