scholarly journals Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

2020 ◽  
Vol 200 ◽  
pp. 112448 ◽  
Author(s):  
Paola Oliva ◽  
Romeo Romagnoli ◽  
Stefano Manfredini ◽  
Andrea Brancale ◽  
Salvatore Ferla ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Furan Derivatives ◽  
Design Synthesis ◽  
Tubulin Polymerization Inhibitors

Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors

ChemMedChem ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. 678-700 ◽  
Author(s):  
Rasala Mahesh ◽  
Vadithe Lakshma Nayak ◽  
Korrapati Suresh Babu ◽  
Syed Riyaz ◽  
Thokhir Basha Shaik ◽  
...  
Keyword(s):  
Tubulin Polymerization ◽  
Design Synthesis ◽  
Tubulin Polymerization Inhibitors

scholarly journals Design, Synthesis and Biological Evaluation of Novel 1, 3, 4-Oxadiazole Bearing Pyridine Moiety

2019 ◽  
pp. 300-307
Author(s):  
Asma D. Ambekari ◽  
Shrinivas K. Mohite
Keyword(s):  
Antimicrobial Activity ◽  
Mass Spectra ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Pyridine Moiety ◽  
Anti Inflammatory ◽  
Physicochemical Data ◽  
Synthesis And Biological Evaluation

Series of novel substituted Synthesis of N-{[5-(substituted)-1,3,4-oxadiazole-2-yl] carbamothioyl} derivatives containing 1,3,4-oxadiazole moiety were synthesized by microwave as a green chemistry method and conventional method by using pyridine 3- carboxylic acid as a starting material. The structures of the synthesized compounds were characterized by physicochemical data, IR, Mass spectra and 1HNMR. All the newly synthesized compound screened for their antimicrobial and In-vivo and In-vitro Anti-inflammatory studies. Anti-inflammatory studies revealed that compound 4f showed significant in-vivo and in-vitro anti-inflammatory activity as well potent antimicrobial activity.

Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors

2017 ◽  
Vol 15 (4) ◽  
pp. 852-862 ◽  
Author(s):  
Baijiao An ◽  
Shun Zhang ◽  
Jun Yan ◽  
Ling Huang ◽  
Xingshu Li
Keyword(s):  
Tubulin Polymerization ◽  
In Vivo Evaluation ◽  
Tubulin Polymerization Inhibitors

In this paper, a series of millepachine derivatives were synthesized and evaluated as tubulin polymerization inhibitors.

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