Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators

2020 ◽  
pp. 113015
Author(s):  
Sergio Algar ◽  
Mercedes Martín-Martínez ◽  
Rosario González-Muñiz
Keyword(s):  
Protein Interaction ◽  
The Road ◽  
Protein Protein Interaction ◽  
Helix Mimetics ◽  
On The Road ◽  
Α Helix

scholarly journals Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR)

MedChemComm ◽  
2013 ◽  
Vol 4 (9) ◽  
pp. 1247-1256 ◽  
Author(s):  
W. Edward Martucci ◽  
Johanna M. Rodriguez ◽  
Melissa A. Vargo ◽  
Matthew Marr ◽  
Andrew D. Hamilton ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Protein Interaction ◽  
Thymidylate Synthase ◽  
Opportunistic Infections ◽  
Molecular Target ◽  
Bifunctional Enzyme ◽  
Cryptosporidium Hominis ◽  
Protein Protein Interaction ◽  
Helix Mimetics ◽  
Α Helix

The bifunctional enzyme TS–DHFR from Cryptosporidium hominis is a molecular target for design of antiparasitic therapies for AIDS-related opportunistic infections.

scholarly journals Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

2015 ◽  
Vol 58 (7) ◽  
pp. 3002-3024 ◽  
Author(s):  
Kwan-Young Jung ◽  
Huabo Wang ◽  
Peter Teriete ◽  
Jeremy L. Yap ◽  
Lijia Chen ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Helix Mimetics ◽  
Α Helix

Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α-Helix-Mediated p53-hDM2 Protein-Protein Interaction

2013 ◽  
Vol 2013 (17) ◽  
pp. 3504-3512 ◽  
Author(s):  
Panchami Prabhakaran ◽  
Anna Barnard ◽  
Natasha S. Murphy ◽  
Colin A. Kilner ◽  
Thomas A. Edwards ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Α Helix

Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold

2006 ◽  
Vol 16 (6) ◽  
pp. 1740-1743 ◽  
Author(s):  
Walfrido Antuch ◽  
Sanjay Menon ◽  
Quin-Zene Chen ◽  
Yingchun Lu ◽  
Sukumar Sakamuri ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Parallel Synthesis ◽  
Protein Protein Interaction ◽  
Α Helix

scholarly journals Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates

ChemMedChem ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. 827-833 ◽  
Author(s):  
Brandon Drennen ◽  
Jacob A. Scheenstra ◽  
Jeremy L. Yap ◽  
Lijia Chen ◽  
Maryanna E. Lanning ◽  
...  
Keyword(s):  
Small Molecules ◽  
Protein Interaction ◽  
Protein Protein Interaction ◽  
Α Helix

Community Colleges: Vital Partners on the Road to Diversity

ASHA Leader ◽  
2006 ◽  
Vol 11 (5) ◽  
pp. 14-17 ◽  
Author(s):  
Shelly S. Chabon ◽  
Ruth E. Cain
Keyword(s):  
Community Colleges ◽  
The Road ◽  
On The Road
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