Chemical probe of AHL modulators on quorum sensing in Gram-Negative Bacteria and as antiproliferative agents: A review

2021 ◽  
Vol 226 ◽  
pp. 113864
Author(s):  
Maxwell Ampomah-Wireko ◽  
Chunying Luo ◽  
Yaquan Cao ◽  
Huanhuan Wang ◽  
Lauraine Nininahazwe ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Gram Negative Bacteria ◽  
Chemical Probe ◽  
Antiproliferative Agents ◽  
Gram Negative

scholarly journals β-Cyclodextrin Interaction with N-Hexanoyl Homoserine Lactone as Quorum Sensing Signal Produced in Gram-Negative Bacteria

2012 ◽  
Vol 37 (2) ◽  
pp. 315-318 ◽  
Author(s):  
Chigusa Okano ◽  
Marina Arai ◽  
Eri Nasuno ◽  
Ken-ichi Iimura ◽  
Tomohiro Morohoshi ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactone ◽  
Gram Negative Bacteria ◽  
Gram Negative

scholarly journals Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

2008 ◽  
Vol 37 (7) ◽  
pp. 1432 ◽  
Author(s):  
Grant D. Geske ◽  
Jennifer C. O’Neill ◽  
Helen E. Blackwell
Keyword(s):  
Quorum Sensing ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Natural Analogues

scholarly journals Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae , Resulting in Hypervirulence

mBio ◽  
2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Claudia Trappetti ◽  
Lauren J. McAllister ◽  
Austen Chen ◽  
Hui Wang ◽  
Adrienne W. Paton ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Quorum Sensing ◽  
Capsular Polysaccharide ◽  
The Body ◽  
Gram Negative Bacteria ◽  
Phosphotransferase System ◽  
Gram Positive ◽  
Gram Negative ◽  
Autoinducer 2 ◽  
Leloir Pathway

ABSTRACT Communication between bacterial cells is crucial for the coordination of diverse cellular processes that facilitate environmental adaptation and, in the case of pathogenic species, virulence. This is achieved by the secretion and detection of small signaling molecules called autoinducers, a process termed quorum sensing. To date, the only signaling molecule recognized by both Gram-positive and Gram-negative bacteria is autoinducer 2 (AI-2), synthesized by the metabolic enzyme LuxS ( S -ribosylhomocysteine lyase) as a by-product of the activated methyl cycle. Homologues of LuxS are ubiquitous in bacteria, suggesting a key role in interspecies, as well as intraspecies, communication. Gram-negative bacteria sense and respond to AI-2 via the Lsr ABC transporter system or by the LuxP/LuxQ phosphorelay system. However, homologues of these systems are absent from Gram-positive bacteria and the AI-2 receptor is unknown. Here we show that in the major human pathogen Streptococcus pneumoniae , sensing of exogenous AI-2 is dependent on FruA, a fructose-specific phosphoenolpyruvate-phosphotransferase system that is highly conserved in Gram-positive pathogens. Importantly, AI-2 signaling via FruA enables the bacterium to utilize galactose as a carbon source and upregulates the Leloir pathway, thereby leading to increased production of capsular polysaccharide and a hypervirulent phenotype. IMPORTANCE S. pneumoniae is a Gram-positive bacterium frequently carried asymptomatically in the human nasopharynx. However, in a proportion of cases, it can spread to other sites of the body, causing life-threatening diseases that translate into massive global morbidity and mortality. Our data show that AI-2 signaling via FruA promotes the transition of the pneumococcus from colonization to invasion by facilitating the utilization of galactose, the principal sugar available in the upper respiratory tract. AI-2-mediated upregulation of Leloir pathway enzymes results in increased production of capsular polysaccharide and hypervirulence in a murine intranasal challenge model. This identifies the highly conserved FruA phosphotransferase system as a target for new antimicrobials based on the disruption of this generic quorum-sensing system.

Quorum sensing between Gram-negative bacteria responsible for methane production in a complex waste sewage sludge consortium

2018 ◽  
Vol 103 (3) ◽  
pp. 1485-1495 ◽  
Author(s):  
Phuong Dong Thi Nguyen ◽  
Nurul Asyifah Mustapha ◽  
Kiwao Kadokami ◽  
Rodolfo Garcia-Contreras ◽  
Thomas K. Wood ◽  
...  
Keyword(s):  
Sewage Sludge ◽  
Quorum Sensing ◽  
Methane Production ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Waste Sewage Sludge

Variations on a Theme: Diverse N-Acyl Homoserine Lactone-Mediated Quorum Sensing Mechanisms in Gram-Negative Bacteria

2006 ◽  
Vol 89 (3-4) ◽  
pp. 167-211 ◽  
Author(s):  
Debra Smith ◽  
Jin-Hong Wang ◽  
Jane E. Swatton ◽  
Peter Davenport ◽  
Bianca Price ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactone ◽  
Acyl Homoserine Lactone ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Variations On A Theme

scholarly journals Quorum sensing signal–response systems in Gram-negative bacteria

2016 ◽  
Vol 14 (9) ◽  
pp. 576-588 ◽  
Author(s):  
Kai Papenfort ◽  
Bonnie L. Bassler
Keyword(s):  
Quorum Sensing ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Response Systems ◽  
Signal Response
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