Variations on a Theme: Diverse N-Acyl Homoserine Lactone-Mediated Quorum Sensing Mechanisms in Gram-Negative Bacteria

2006 ◽  
Vol 89 (3-4) ◽  
pp. 167-211 ◽  
Author(s):  
Debra Smith ◽  
Jin-Hong Wang ◽  
Jane E. Swatton ◽  
Peter Davenport ◽  
Bianca Price ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactone ◽  
Acyl Homoserine Lactone ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Variations On A Theme

scholarly journals β-Cyclodextrin Interaction with N-Hexanoyl Homoserine Lactone as Quorum Sensing Signal Produced in Gram-Negative Bacteria

2012 ◽  
Vol 37 (2) ◽  
pp. 315-318 ◽  
Author(s):  
Chigusa Okano ◽  
Marina Arai ◽  
Eri Nasuno ◽  
Ken-ichi Iimura ◽  
Tomohiro Morohoshi ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactone ◽  
Gram Negative Bacteria ◽  
Gram Negative

scholarly journals N-Acyl homoserine lactone-mediated quorum sensing in pathogenic Aeromonas veronii biovar sobria strain 159: Identification of LuxIR homologs

2015 ◽  
Author(s):  
Xin Yue Chan ◽  
Kah Yan How ◽  
Wai Fong Yin ◽  
Kok Gan Chan
Keyword(s):  
Quorum Sensing ◽  
Bacterial Population ◽  
Gene Annotation ◽  
Homoserine Lactone ◽  
Genome Comparison ◽  
Acyl Homoserine Lactone ◽  
Gram Negative Bacteria ◽  
Signalling Molecules ◽  
Aeromonas Veronii ◽  
High Degree

Quorum sensing (QS) is a mechanism that plays important roles in gene expression in response to an expanding bacterial population. In many Gram-negative bacteria, N-acyl homoserine lactone is mainly secreted as the diffusible signalling molecules. This QS system has been shown to control diverse array of virulence and secondary metabolism. Recently, whole genome sequencing of Aeromonas veronii biovar sobria strain 159 was performed. Genome comparison with closely-related Aeromonas species showed that A. veronii strain 159 shares a high degree of genome synteny with A. hydrophila ATCC 7966. A detailed genome analysis and gene annotation led us to the findings that A. veronii strain 159 harbors QS system which relies on its signal generator, AveI and the transcriptional regulator, AveR. This Aeromonas strain was found to secrete N-butanoylacyl homoserine lactone (C4-HSL). Its LuxIR homologs are similar to proteins of LuxIR famililies among Aeromonas species. This study aims to gain further insights into AveIR system and to compare with AhyIR from A. hydrophila ATCC 7966 and AsaIR from A. salmonicida.

Indole-based novel small molecules for the modulation of bacterial signalling pathways

2015 ◽  
Vol 13 (3) ◽  
pp. 925-937 ◽  
Author(s):  
Nripendra Nath Biswas ◽  
Samuel K. Kutty ◽  
Nicolas Barraud ◽  
George M. Iskander ◽  
Renate Griffith ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Small Molecules ◽  
Antimicrobial Agents ◽  
Homoserine Lactone ◽  
Signalling Pathways ◽  
Gram Negative Bacteria ◽  
Gram Negative

Indole basedN-acylatedl-homoserine lactone (AHL) mimics were developed as quorum sensing (QS) inhibitors for Gram-negative bacteriaPseudomonas aeruginosaand can be used as novel antimicrobial agents.

scholarly journals The Transcriptional Activator rfiA Is Quorum-Sensing Regulated by Cotranscription with the luxI Homolog pcoI and Is Essential for Plant Virulence in Pseudomonas corrugata

2009 ◽  
Vol 22 (12) ◽  
pp. 1514-1522 ◽  
Author(s):  
Grazia Licciardello ◽  
Iris Bertani ◽  
Laura Steindler ◽  
Patrizia Bella ◽  
Vittorio Venturi ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactone ◽  
Acyl Homoserine Lactone ◽  
Dna Binding Domain ◽  
Pseudomonas Corrugata ◽  
Gram Negative ◽  
Rnd Transporter ◽  
Pith Necrosis ◽  
Rhodotorula Pilimanae

The gram-negative phytopathogen Pseudomonas corrugata has an acyl-homoserine lactone (AHL) quorum-sensing (QS) system called PcoI/PcoR that is involved in virulence on tomato. This work identifies, downstream of pcoI, a gene designated rfiA, which we demonstrate is directly linked to QS by cotranscription with pcoI. The deduced RfiA protein contains a DNA-binding domain characteristic of the LuxR family but lacks the autoinducer-binding terminus characteristic of the QS LuxR-family proteins. We also identified, downstream of rfiA, an operon designated pcoABC, encoding for the three components of a tripartite resistance nodulation-cell-division (RND) transporter system. The expression of pcoABC is regulated by RfiA. We found that lipodepsipeptide (LDP) production is cell density dependent and mutants of pcoI, pcoR, and rfiA are unable to inhibit the growth of the LDP-sensitive microorganisms Rhodotorula pilimanae and Bacillus megaterium. P. corrugata rfiA mutants were significantly reduced in their ability to cause necrosis development in tomato pith. In addition, it was established that PcoR in the absence of AHL also played a role in virulence on tomato. A model for the role of PcoI, PcoR, and RfiA in tomato pith necrosis is presented.

scholarly journals Bioactive compound that inhabit quorum sensing system in gram negative bacteria

2006 ◽  
Vol 4 (1) ◽  
pp. 34-40
Author(s):  
NUR AINI ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Quorum Sensing ◽  
Bioactive Compound ◽  
Homoserine Lactone ◽  
Cell Number ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Sensing System ◽  
Delisea Pulchra ◽  
Novel Target ◽  
Flustra Foliacea

Bacteria communicate using chemical signaling molecules as words. They release, detect, and respond to the accumulation of these molecules, which are called autoinducers. Detection of autoinducers allows bacteria to distinguish between low and high cell population density, and to control gene expression in response to changes the cell number. This process is termed quorum sensing. Many bacterial behaviors are regulated by quorum sensing, including virulence factors on gram negative bacteria. Quorum sensing is a novel target for antimicrobial therapies. Many eukariots including plants, fungus, and animals produce molecules that can interfered bacteria communication, such as halogen furanon from alga Delisea pulchra, N- (heptylsulfanylacetyl)-L-homoserine-lactone from Allium sativum, and flustramine from bryozoan Flustra foliacea.

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