scholarly journals Thorotrast and in vivo thorium dioxide: Numerical simulation of 30 years of α radiation absorption by the tissues near a large compact source

2014 ◽  
Vol 30 (4) ◽  
pp. 489-496 ◽  
Author(s):  
A. Bianconi
Author(s):  
Shigefumi Tokuda ◽  
Takeshi Unemura ◽  
Marie Oshima

Cerebrovascular disorder such as subarachnoid hemorrhage (SAH) is 3rd position of the cause of death in Japan [1]. Its initiation and growth are reported to depend on hemodynamic factors, particularly on wall shear stress or blood pressure induced by blood flow. In order to investigate the information on the hemodynamic quantities in the cerebral vascular system, the authors have been developing a computational tool using patient-specific modeling and numerical simulation [2]. In order to achieve an in vivo simulation of living organisms, it is important to apply appropriate physiological conditions such as physical properties, models, and boundary conditions. Generally, the numerical simulation using a patient-specific model is conducted for a localized region near the research target. Although the analysis region is only a part of the circulatory system, the simulation has to include the effects from the entire circulatory system. Many studies have carried out to derive the boundary conditions to model in vivo environment [3–5]. However, it is not easy to obtain the biological data of cerebral arteries due to head capsule.


1996 ◽  
Vol 42 (2-3) ◽  
pp. 245-253 ◽  
Author(s):  
Alexandrina D. Stirbet ◽  
Reto J. Strasser

2013 ◽  
Vol 71 (5) ◽  
pp. 1923-1931 ◽  
Author(s):  
Sukhoon Oh ◽  
Yeun-Chul Ryu ◽  
Giuseppe Carluccio ◽  
Christopher T. Sica ◽  
Christopher M. Collins

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
Ephraim Sparrow ◽  
John Abraham ◽  
Yilmaz Bayazit ◽  
Ryan Lovik ◽  
Dianna Smith

In the design of medical devices, the use of numerical simulation, either with or without complementary experimentation, may lead to a more competent product. The experimentation in question may either be performed in vitro or in vivo. This paper conveys a case study in which the two methodologies, numerical simulation and in vitro experimentation used in tandem, enabled the evaluation of safety issues related to a heat-generating implant. The numerical simulation was implemented by means of ANSYS finite-element software employed in the transient mode. The experimental work provided information necessary for the execution of the simulation and, therefore, was performed as the first phase of the research. The implant is of the type that is equipped with a short-lived battery that requires intermittent recharging. The recharging is accomplished by means of an antenna that is externally mounted on the skin surface. The antenna is the primary of a transformer, and the implant contains the secondary of the transformer. During the recharging period of the battery, heat is generated in both the antenna and the implant. By the symbiotic use of the experimental results and the numerical simulation, time-dependent temperatures were determined in the tissue that is situated in the neighborhood of the implant and the antenna. These temperatures were evaluated from the standpoint of possible tissue damage.


2014 ◽  
Vol 13 (1) ◽  
pp. e362-e362a
Author(s):  
R.E. Neal ◽  
P. Royce ◽  
J.L. Millar ◽  
H. Kavnoudias ◽  
F. Rosenfeldt ◽  
...  

Author(s):  
Takushi Saito ◽  
Isao Satoh ◽  
Tatsuya Kawaguchi

In this study, the authors added a functional dye to a material which was transparent in initial state, to locally change the radiation absorption coefficient of the material. By using this material, we proposed a radiation heating technique that can achieve a selective local heating in three-dimensional system and investigated its feasibility. Temperature change of the test sample was measured in the experiment, and the characteristic of the presenting technique was investigated. To obtain better understanding of the presenting technique, numerical simulation of the temperature distribution inside the sample was also performed. In the experiment, photochromic dye and thermochromic dye were used as functional dyes and they were individually added to thermoplastic polymeric material (polystyrene) by using organic solvent (tetrahydrofuran). Then the material containing the dye was dried and processed to give a certain shape for the experiment. He-Cd laser and Ar ion laser were properly used as the excitation and the heat sources according to the type of dye. Experimental result showed that local heating of the material was achieved only in quite thin surface region in case of photochromic dye. On the other hand, local heating inside the material was successfully achieved in case of thermochromic dye. However, it was also observed that the heating point was moved to the upstream direction of the laser beam. To examine the solution of this problem, effect of the laser irradiation conditions on the moving speed of the heating point was discussed based on the numerical simulation results.


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