Prospective long-term results, complications and risk factors in pelvic organ prolapse treatment with vaginal mesh

2017 ◽  
Vol 211 ◽  
pp. 62-67 ◽  
Author(s):  
Inés M. Laso-García ◽  
Miguel A. Rodríguez-Cabello ◽  
Miguel A. Jiménez-Cidre ◽  
Andrea Orosa-Andrada ◽  
David Carracedo-Calvo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Vaginal Mesh ◽  
Long Term Results

Long-term observation on postoperative recurrence and complications of transvaginal mesh surgery for pelvic organ prolapse

2021 ◽  
Author(s):  
Junfang Yang ◽  
Kun Zhang ◽  
Jinsong Han ◽  
Yiting Wang ◽  
Ying Yao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pelvic Organ Prolapse ◽  
Protective Factor ◽  
Pelvic Organ ◽  
Vaginal Mesh ◽  
Transvaginal Mesh ◽  
Mesh Exposure ◽  
Mesh Surgery ◽  
Post Menopause

Objective: This study aims to evaluate the risk factors for subjective recurrence and complications of patients who underwent transvaginal synthetic mesh surgery. Design：This retrospective cohort study included patients who received transvaginal mesh (TVM) surgery between January 2005 and June 2019. Methods: The information of patients was collected, including basic characteristics, subjective recurrence, and mesh-related complications. The clinical characteristics of patients with and without subjective recurrence were compared. The sexual activities of patients before and after the operation were recorded. SPSS 20.0 was used for the statistical analysis. Results: A total of 257 patients were included. Among them, 62 (24.1%) patients were lost to follow-up. The median follow-up time was 80 months (12 months, 170 months). Finally, 195 patients were followed up, 11 (5.6%) patients had a subjective recurrence of pelvic organ prolapse, and 26 (13.3%) patients had mesh-related complications (11 patients with de novo pain and 15 patients with mesh exposure). We found significant differences in age (68.9±5.1 vs. 63.4±5.8 years old), years of post-menopause (17.5±6.3 vs. 13.3±6.9 years), previous hysterectomy (27.3% vs. 6.0%), and concomitant hysterectomy (45.5% vs. 81.0%) between patients with and without subjective recurrence (P<0.05). The mesh exposure proportion of patients with total vaginal mesh (47.6%) was significantly higher than that with anterior vaginal mesh (2.9%) (P<0.05). Furthermore, 6.7% of sexually active patients reported do novo dyspareunia. Limitation: The investigators could only record the subjective recurrence of patients, thus there is a lack of objective recurrence data. Conclusion: Age, years of post-menopause and previous hysterectomy are risk factors for subjective recurrence of transvaginal mesh surgery; however，concomitant hysterectomy is a protective factor. Mesh exposure is the most common complication, especially for total vaginal mesh repair surgery.

scholarly journals Risk factors and management of vaginal mesh erosion after pelvic organ prolapse surgery

2017 ◽  
Vol 56 (2) ◽  
pp. 184-187 ◽  
Author(s):  
Yung-Wen Cheng ◽  
Tsung-Hsien Su ◽  
Hsuan Wang ◽  
Wen-Chu Huang ◽  
Hui-Hsuan Lau
Keyword(s):  
Risk Factors ◽  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Mesh Erosion ◽  
Vaginal Mesh ◽  
Prolapse Surgery ◽  
Pelvic Organ Prolapse Surgery

379 Long-term efficacy and safety of pelvic organ prolapse (POP) treatment with tension-free vaginal mesh

2014 ◽  
Vol 13 (1) ◽  
pp. e379-e379a
Author(s):  
Cabello M.A. Rodriguez ◽  
García I. Laso ◽  
Andrada A. Orosa ◽  
Calvo D. Carracedo ◽  
J.M. Gómez De Vicente ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Vaginal Mesh ◽  
Efficacy And Safety ◽  
Tension Free ◽  
Term Efficacy

scholarly journals Long-term results of robotic sacral hysteropexy for pelvic organ prolapse in China Single medical center

2016 ◽  
Vol 27 ◽  
pp. 128-132 ◽  
Author(s):  
Xiu-li Li ◽  
Zhong-Yu Liu ◽  
Ning Zhou ◽  
Tongyu Zhu ◽  
Yi-Zhuo Yang ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Medical Center ◽  
Pelvic Organ ◽  
Long Term Results ◽  
Sacral Hysteropexy

scholarly journals Efficacy of native tissue repair for pelvic organ prolapse: long-term results

2016 ◽  
Vol 206 ◽  
pp. e18-e19
Author(s):  
Ruby Martinello ◽  
Chiara Borghi ◽  
Giulia Bernardi ◽  
Gennaro Scutiero ◽  
Gloria Bonaccorsi ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Tissue Repair ◽  
Pelvic Organ ◽  
Long Term Results ◽  
Native Tissue Repair ◽  
Native Tissue

Examinations of a new long-term degradable electrospun polycaprolactone scaffold in three rat abdominal wall models

2017 ◽  
Vol 31 (7) ◽  
pp. 1077-1086 ◽  
Author(s):  
Hanna Jangö ◽  
Søren Gräs ◽  
Lise Christensen ◽  
Gunnar Lose
Keyword(s):  
Pelvic Organ Prolapse ◽  
Foreign Body ◽  
Abdominal Wall ◽  
Muscle Fiber ◽  
Pelvic Organ ◽  
Foreign Body Response ◽  
Heavy Load ◽  
Tissue Construct ◽  
Body Response

Alternative approaches to reinforce native tissue in reconstructive surgery for pelvic organ prolapse are warranted. Tissue engineering combines the use of a scaffold with the regenerative potential of stem cells and is a promising new concept in urogynecology. Our objective was to evaluate whether a newly developed long-term degradable polycaprolactone scaffold could provide biomechanical reinforcement and function as a scaffold for autologous muscle fiber fragments. We performed a study with three different rat abdominal wall models where the scaffold with or without muscle fiber fragments was placed (1) subcutaneously (minimal load), (2) in a partial defect (partial load), and (3) in a full-thickness defect (heavy load). After 8 weeks, no animals had developed hernia, and the scaffold provided biomechanical reinforcement, even in the models where it was subjected to heavy load. The scaffold was not yet degraded but showed increased thickness in all groups. Histologically, we found a massive foreign body response with numerous large giant cells intermingled with the fibers of the scaffold. Cells from added muscle fiber fragments could not be traced by PKH26 fluorescence or desmin staining. Taken together, the long-term degradable polycaprolactone scaffold provided biomechanical reinforcement by inducing a marked foreign-body response and attracting numerous inflammatory cells to form a strong neo-tissue construct. However, cells from the muscle fiber fragments did not survive in this milieu. Properties of the new neo-tissue construct must be evaluated at the time of full degradation of the scaffold before its possible clinical value in pelvic organ prolapse surgery can be evaluated.

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