scholarly journals Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion

2019 ◽  
Vol 16 (10) ◽  
pp. 4361-4371 ◽  
Author(s):  
Ecaterina Bordos ◽  
Muhammad T. Islam ◽  
Alastair J. Florence ◽  
Gavin W. Halbert ◽  
John Robertson
Keyword(s):  
Raman Spectroscopy ◽  
Active Pharmaceutical Ingredient ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Polymeric Matrices ◽  
Hot Melt

The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusion

2007 ◽  
Vol 103 (2-3) ◽  
pp. 419-426 ◽  
Author(s):  
John G. Lyons ◽  
Harshad Holehonnur ◽  
Declan M. Devine ◽  
James E. Kennedy ◽  
Luke M. Geever ◽  
...  
Keyword(s):  
Layered Silicate ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Polymeric Matrices ◽  
Organically Modified ◽  
Hot Melt

In-line Raman spectroscopy and chemometrics for monitoring cocrystallisation using hot melt extrusion

2021 ◽  
pp. 120555
Author(s):  
Maryam Karimi-Jafari ◽  
Rodrigo Soto ◽  
Ahmad B. Albadarin esources ◽  
Denise Croker ◽  
Gavin Walker
Keyword(s):  
Raman Spectroscopy ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 116 ◽  
Author(s):  
Lærke Arnfast ◽  
Jeroen van Renterghem ◽  
Johanna Aho ◽  
Johan Bøtker ◽  
Dhara Raijada ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Process Parameters ◽  
Hot Melt Extrusion ◽  
Multivariate Curve Resolution ◽  
Detectable Effect ◽  
Melt Extrusion ◽  
Critical Process Parameters ◽  
Solid Form ◽  
Critical Process ◽  
Hot Melt

The specific aim in this study was to understand the effect of critical process parameters on the solid form composition of model drug compounds during hot melt extrusion using in-line Raman spectroscopy combined with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) modeling for semi-quantitative kinetic profiling. It was observed that the hydrate and anhydrate solid forms of two model drugs in the melts of nitrofurantoin (NF):polyethylene oxide (PEO) and piroxicam (PRX):PEO could be resolved from a MCR-ALS model without an external calibration dataset. Based on this model, the influence of two critical process parameters (shear and temperature) on the solid form composition could be evaluated in a real-time mode and the kinetics of complex transformation pathways could be explored. Additionally, the dehydration pathways of NF monohydrate and PRX monohydrate in molten PEO could be derived. It can be concluded that dehydration of both hydrates in PEO occurs via competing mechanisms—a solution-mediated transformation pathway and a solid–solid transformation, and that the balance between these mechanisms is determined by the combined effect of both temperature and shear. Another important observation was that the water released from these hydrate compounds has a detectable effect on the rheological characteristics of this mixture.

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