Development and evaluation of accelerated drug release testing methods for a matrix-type intravaginal ring

2017 ◽  
Vol 110 ◽  
pp. 1-12 ◽  
Author(s):  
Anna Externbrink ◽  
Karin Eggenreich ◽  
Simone Eder ◽  
Stefan Mohr ◽  
Klaus Nickisch ◽  
...  
Keyword(s):  
Drug Release ◽  
Testing Methods ◽  
Matrix Type ◽  
Intravaginal Ring ◽  
Release Testing

Drug release testing methods of polymeric particulate drug formulations

2013 ◽  
Vol 43 (4) ◽  
pp. 259-266 ◽  
Author(s):  
Sarmila Amatya ◽  
Eun Ji Park ◽  
Jong Hoon Park ◽  
Joon Sik Kim ◽  
Eunyoung Seol ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Formulations ◽  
Testing Methods ◽  
Release Testing

scholarly journals Recent Progress in Drug Release Testing Methods of Biopolymeric Particulate System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1313
Author(s):  
Yejin Kim ◽  
Eun Ji Park ◽  
Tae Wan Kim ◽  
Dong Hee Na
Keyword(s):  
Drug Release ◽  
In Vitro Release ◽  
Testing Methods ◽  
In Vitro Drug Release ◽  
Particulate System ◽  
Vitro Release ◽  
Release Testing

Biopolymeric microparticles have been widely used for long-term release formulations of short half-life chemicals or synthetic peptides. Characterization of the drug release from microparticles is important to ensure product quality and desired pharmacological effect. However, there is no official method for long-term release parenteral dosage forms. Much work has been done to develop methods for in vitro drug release testing, generally grouped into three major categories: sample and separate, dialysis membrane, and continuous flow (flow-through cell) methods. In vitro drug release testing also plays an important role in providing insight into the in vivo performance of a product. In vitro release test with in vivo relevance can reduce the cost of conducting in vivo studies and accelerate drug product development. Therefore, investigation of the in vitro–in vivo correlation (IVIVC) is increasingly becoming an essential part of particulate formulation development. This review summarizes the principles of the in vitro release testing methods of biopolymeric particulate system with the recent research articles and discusses their characteristics including IVIVC, accelerated release testing methods, and stability of encapsulated drugs.

scholarly journals Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

2021 ◽  
pp. 105867
Author(s):  
Shaolong He ◽  
Jette Jacobsen ◽  
Carsten Uhd Nielsen ◽  
Natalja Genina ◽  
Jesper Østergaard ◽  
...  
Keyword(s):  
Drug Release ◽  
Testing Methods ◽  
In Vitro Drug Release ◽  
Microenvironmental Ph ◽  
Release Testing ◽  
Buccal Films

In vitro drug release testing of controlled release veterinary drug products

2000 ◽  
pp. 311-332 ◽  
Author(s):  
Michael J. Rathbone ◽  
Jingjian Shen ◽  
Colin R. Ogle ◽  
Shane Burggraaf ◽  
Craig R. Bunt
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Veterinary Drug ◽  
In Vitro Drug Release ◽  
Drug Products ◽  
Release Testing

In vitro release testing methods for vitamin E nanoemulsions

2014 ◽  
Vol 475 (1-2) ◽  
pp. 393-400 ◽  
Author(s):  
Jacqueline M. Morais ◽  
Diane J. Burgess
Keyword(s):  
Vitamin E ◽  
In Vitro Release ◽  
Testing Methods ◽  
Vitro Release ◽  
Release Testing

Synthesis of antibiotic-loaded interporous hydroxyapatite blocks by vacuum method and in vitro drug release testing

Biomaterials ◽  
1998 ◽  
Vol 19 (7-9) ◽  
pp. 817-819 ◽  
Author(s):  
Mansho Itokazu ◽  
Wenyi Yang ◽  
Takaaki Aoki ◽  
Akira Ohara ◽  
Naoki Kato
Keyword(s):  
Drug Release ◽  
In Vitro Drug Release ◽  
Vacuum Method ◽  
Release Testing

Unattended, robotic drug-release testing of enterically coated aspirin

1986 ◽  
Vol 58 (11) ◽  
pp. 2316-2320 ◽  
Author(s):  
R. J. Eckstein ◽  
Grover D. Owens ◽  
M. A. Baim ◽  
D. A. Hudson
Keyword(s):  
Drug Release ◽  
Release Testing

Development of Acrylic Matrix Type Ketoprofen Patch

2012 ◽  
Vol 506 ◽  
pp. 533-536
Author(s):  
Nanthida Wonglertnirant ◽  
S. Tipwichai ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Suwannee Panomsuk ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Pressure Sensitive Adhesive ◽  
Drug Release Rate ◽  
Matrix Type ◽  
Adhesive Matrix ◽  
Pressure Sensitive ◽  
Transdermal Patches ◽  
Significant Difference

Ketoprofen transdermal patches (KTPs) were fabricated using an acrylic pressure sensitive adhesive (PSA) polymer. The influence of different factors (amount of PSA, drug content, and pressure applying on the backing membrane during preparation) on the characteristics of ketoprofen patch (thickness, W/A ratio, and adhesiveness of matrix film) and in vitro drug release behavior were investigated. The results revealed the successful fabrication and a good physical appearance of KTPs using acrylic PSA. Microscopic observations, FTIR spectra, and DSC thermograms were permitted to demonstrate that the drug was dispersed molecularly in the polymer. As the amount of PSA in the adhesive matrix was increased, the release rate of ketoprofen was decreased. Contrarily, the drug release rate was increased corresponding to the increase of ketoprofen content in the adhesive matrix. There was no significant difference in the release rate when the pressure applying on the backing membrane was varied. The kinetic of ketoprofen release from acrylic matrix type transdermal patches followed the Higuchis diffusion model.

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