Development of Acrylic Matrix Type Ketoprofen Patch

2012 ◽  
Vol 506 ◽  
pp. 533-536
Author(s):  
Nanthida Wonglertnirant ◽  
S. Tipwichai ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Suwannee Panomsuk ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Pressure Sensitive Adhesive ◽  
Drug Release Rate ◽  
Matrix Type ◽  
Adhesive Matrix ◽  
Pressure Sensitive ◽  
Transdermal Patches ◽  
Significant Difference

Ketoprofen transdermal patches (KTPs) were fabricated using an acrylic pressure sensitive adhesive (PSA) polymer. The influence of different factors (amount of PSA, drug content, and pressure applying on the backing membrane during preparation) on the characteristics of ketoprofen patch (thickness, W/A ratio, and adhesiveness of matrix film) and in vitro drug release behavior were investigated. The results revealed the successful fabrication and a good physical appearance of KTPs using acrylic PSA. Microscopic observations, FTIR spectra, and DSC thermograms were permitted to demonstrate that the drug was dispersed molecularly in the polymer. As the amount of PSA in the adhesive matrix was increased, the release rate of ketoprofen was decreased. Contrarily, the drug release rate was increased corresponding to the increase of ketoprofen content in the adhesive matrix. There was no significant difference in the release rate when the pressure applying on the backing membrane was varied. The kinetic of ketoprofen release from acrylic matrix type transdermal patches followed the Higuchis diffusion model.

Effects of Four Mesostructures on their Drug Release Properties

2013 ◽  
Vol 645 ◽  
pp. 125-128
Author(s):  
Wei Zeng
Keyword(s):  
Drug Release ◽  
Mesoporous Materials ◽  
Release Rate ◽  
Drug Efficacy ◽  
Drug Release Rate ◽  
Ordered Mesoporous Materials ◽  
Ordered Mesoporous ◽  
Fast Release ◽  
Mcm 41

Five ordered mesoporous materials, SBA-1, MCM-48, SBA-7, MCM-41 and SBA-15, were prepared and tested as mesophase drug delivery systems with an anti-inflammatory drug, ibuprofen. The results of these mesostructures on in vitro ibuprofen delivery indicated that the mesoporous materials with cage-like structure, SBA-1 and SBA-7, had unfavorable load and release properties. MCM-48 also showed fast release rate due to its opening channel. However, the hexagonal mesostructure in MCM-41 and SAB-15 was advantageous for extending drug release rate although a little difference existed between them. Compared with commercial ibuprofen capsule, the release system based on MCM-41 materials displayed the drug efficacy in a longer time.

scholarly journals Drug release rate in vitro and bioavailability of new controlled release suspension of spherical matrix of ibuprofen.

1989 ◽  
Vol 4 (2) ◽  
pp. 100-104
Author(s):  
Yoshiaki Kawashima ◽  
Taro Iwamoto ◽  
Toshiyuki Niwa ◽  
Hirofumi Takeuchi ◽  
Tomoaki Hino ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Rate ◽  
Drug Release Rate

scholarly journals Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application

2021 ◽  
Vol 22 (21) ◽  
pp. 11840
Author(s):  
Paula Ossowicz-Rupniewska ◽  
Paulina Bednarczyk ◽  
Małgorzata Nowak ◽  
Anna Nowak ◽  
Wiktoria Duchnik ◽  
...  
Keyword(s):  
Transdermal Drug Delivery ◽  
Medical Application ◽  
Adhesive Properties ◽  
Pressure Sensitive Adhesives ◽  
Adhesive Matrix ◽  
Pressure Sensitive ◽  
Transdermal Patches ◽  
Relevant Dose ◽  
Synthesis Routes

This study aimed to investigate the potential of photoreactive acrylate patches as systems for transdermal drug delivery, in particular, using more renewable alternatives and more environmentally friendly synthesis routes of transdermal patches. Therefore, the aim of this study was to develop a transdermal patch containing ibuprofen and investigate its performance in vitro through the pigskin. Transparent patches were prepared using four acrylate copolymers with an incorporated photoinitiator. Two types of transdermal patches based on the photocrosslinking acrylic prepolymers with isobornyl methacrylate as biocomponent and monomer increasing Tg (“hard”) were manufactured. The obtained patches were characterized for their adhesive properties and tested for permeability of the active substance. It turns out that patches whose adhesive matrix is photoreactive polyacrylate copolymers have a higher cohesion than patches from commercial adhesives, while the modification of the copolymers with isobornyl methacrylate resulted in an improvement in adhesion and tack. This study demonstrates the feasibility of developing photoreactive acrylic-based transdermal patches that contain biocomponents that can deliver a therapeutically relevant dose of ibuprofen.

Design and Development of Propranolol Hydrochloride Transdermal Patches: In Vitro and Ex Vivo Characterization

2020 ◽  
Vol 3 (1) ◽  
pp. 01-08
Author(s):  
Chinthakindi Shravya
Keyword(s):  
Drug Release ◽  
Moisture Absorption ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Diffusion Mechanism ◽  
Propranolol Hydrochloride ◽  
Matrix Type ◽  
Transdermal Patches ◽  
Percent Moisture

The main aim of this investigation is to design and develop matrix type transdermal patches of Propranolol Hydrochloride which is an anti-hypertensive drug. These matrix type transdermal patches were prepared by “Solvent Casting Technique” using drug, HPMC E15 and Eudragit L 100 in the ratio of 1:6, 1:6.5, 1:7, 1:7.5, 1:8, 1:8.5, 1:9, 1:9.5. All formulations carried 20%v/w of PEG-600 as plasticizer. The prepared patches were characterized for various physicochemical parameters like weight, thickness, folding endurance, drug content, percent moisture content, percent moisture absorption, in vitro drug release and ex vivo permeation. Among this 1:9 ratio was found to be an Optimized formulation and patches were prepared by using permeation enhancers (lemon grass oil, Eucalyptus oil, and clove oil). The cumulative amount of drug release in 12hrs for F7 formulation showed maximum and used for that formulation skin permeation on Goat abdominal skin. FTIR studies show no interaction between drug, polymer and other excipients. The drug permeation kinetics followed “First order” and “zero order” profile with diffusion mechanism.

Formulation and Evaluation of Isosorbide Dinitrate Acrylic Matrix Transdermal Patches

2011 ◽  
Vol 197-198 ◽  
pp. 1217-1220
Author(s):  
Ponwanit Jarenputtakrun ◽  
Praneet Opanasopit ◽  
Suwannee Panomsuk ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Propylene Glycol ◽  
Isosorbide Dinitrate ◽  
Skin Permeation ◽  
Casting Method ◽  
Pressure Sensitive Adhesive ◽  
Transdermal Drug Delivery System ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Transdermal Patches

The aim of this study was to prepare and investigate the isosorbide dinitrate transdermal patches (IDPs) in the concentration of 40 mg/cm2. Acrylic pressure sensitive adhesives (PSA) were used to formulate IDPs. IDPs were prepared by casting method. The effect of content of PSA, and concentration of enhancer, propylene glycol, in the formulations were evaluated. IDPs were investigated for their thickness, weight/area ratio, adhesiveness and in vitro skin permeation. The higher the content of PSA in the formulation, the higher the thickness and the W/A ratio. Propylene glycol added in the formulation (2.5, 5, 10%) significantly enhanced the skin permeation of ISDN. The higher the content of PG, the higher the flux of ISDN through the skin. Our research suggests that isosorbide dinitrate loaded with 10% of propylene glycol in acrylic matrix pressure sensitive adhesive can be potentially used as a transdermal drug delivery system.

scholarly journals FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PLUMBAGIN FOR ANTI-FUNGAL ACTIVITIES

2021 ◽  
Vol 12 (2) ◽  
pp. 23-28
Author(s):  
Aman Sharma ◽  
Abhinav Agarwal
Keyword(s):  
Drug Release ◽  
Sustained Drug Release ◽  
Release Formulation ◽  
In Vitro Drug Release ◽  
Matrix Type ◽  
Transdermal Patches ◽  
Weight Variation ◽  
The Matrix ◽  
Anti Fungal

The objective of the current study is to improve the patient compliance and sustained drug release action by herbal medicine which can be achieved by developing alternative drug delivery system. The matrix type transdermal patches containing plumbagin were prepared by solvent evaporation method with different ratios of polymers (HPMC 50cps, PVP K29-32 and EUDRAGIT RS-100). In these matrix type transdermal patches, the PEG (Polyethylene glycol) was used as plasticizer and DMSO (Dimethyl sulfoxide) used as a penetration enhancer. The formulated patches were evaluated for physicochemical parameters like thickness, weight variation, % moisture content, % moisture uptake, % flatness, folding endurance and drug content. In vitro drug release studies were carried out by using the Franz diffusion cell. The cumulative % of drug released in 10 hours from the six batch formulations were 95.66%, 94.2%, 97.33%, 90.13%, 83.75% and 85.71%, respectively. On the basis of in-vitro drug release, formulation (HE-2) was found to be better than other formulation and these were selected for further evaluation such as anti-fungal activity and stability studies.

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