scholarly journals A comparison of three mucus-secreting airway cell lines (Calu-3, SPOC1 and UNCN3T) for use as biopharmaceutical drug absorption models of the nose and lung

2021 ◽  
Author(s):  
Diane F.Lee ◽  
Mike I. Lethem ◽  
Alison B.Lansley
Keyword(s):  
Cell Lines ◽  
Drug Absorption ◽  
Absorption Models

scholarly journals Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 411 ◽  
Author(s):  
David Dahlgren ◽  
Hans Lennernäs
Keyword(s):  
Intestinal Permeability ◽  
Drug Absorption ◽  
Pharmaceutical Products ◽  
Physiological Factors ◽  
Drug Products ◽  
Absorption Models ◽  
Gi Absorption ◽  
Multiple Interactions

The main objective of this review is to discuss recent advancements in the overall investigation and in vivo prediction of drug absorption. The intestinal permeability of an orally administered drug (given the value Peff) has been widely used to determine the rate and extent of the drug’s intestinal absorption (Fabs) in humans. Preclinical gastrointestinal (GI) absorption models are currently in demand for the pharmaceutical development of novel dosage forms and new drug products. However, there is a strong need to improve our understanding of the interplay between pharmaceutical, biopharmaceutical, biochemical, and physiological factors when predicting Fabs and bioavailability. Currently, our knowledge of GI secretion, GI motility, and regional intestinal permeability, in both healthy subjects and patients with GI diseases, is limited by the relative inaccessibility of some intestinal segments of the human GI tract. In particular, our understanding of the complex and highly dynamic physiology of the region from the mid-jejunum to the sigmoid colon could be significantly improved. One approach to the assessment of intestinal permeability is to use animal models that allow these intestinal regions to be investigated in detail and then to compare the results with those from simple human permeability models such as cell cultures. Investigation of intestinal drug permeation processes is a crucial biopharmaceutical step in the development of oral pharmaceutical products. The determination of the intestinal Peff for a specific drug is dependent on the technique, model, and conditions applied, and is influenced by multiple interactions between the drug molecule and the biological membranes.

In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity

2009 ◽  
Vol 61 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Michaela Madlova ◽  
Cynthia Bosquillon ◽  
Dan Asker ◽  
Pavel Dolezal ◽  
Ben Forbes
Keyword(s):  
Drug Absorption ◽  
P Glycoprotein ◽  
Absorption Models

In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity

2009 ◽  
Vol 61 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Michaela Madlova ◽  
Cynthia Bosquillon ◽  
Dan Asker ◽  
Pavel Dolezal ◽  
Ben Forbes
Keyword(s):  
Drug Absorption ◽  
P Glycoprotein ◽  
Absorption Models

Comment on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-Based Absorption Models”

2016 ◽  
Vol 14 (1) ◽  
pp. 336-339 ◽  
Author(s):  
David B. Turner ◽  
Bo Liu ◽  
Nikunjkumar Patel ◽  
Shriram M. Pathak ◽  
Sebastian Polak ◽  
...  
Keyword(s):  
Drug Absorption ◽  
In Silico ◽  
Predictive Performance ◽  
In Silico Modeling ◽  
Physiologically Based ◽  
Absorption Models
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