Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist

2004 ◽  
Vol 498 (1-3) ◽  
pp. 171-177 ◽  
Author(s):  
Hironori Yuyama ◽  
Yukiko Noguchi ◽  
Akira Fujimori ◽  
Masashi Ukai ◽  
Noriko Fujiyasu ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Eta Receptor ◽  
Eta Receptor Antagonist

BQ123, an ETA Receptor Antagonist, Attenuates Endothelin-1-Induced Vasoconstriction in Rat Pulmonary Circulation

1993 ◽  
Vol 22 (1) ◽  
pp. 39-43 ◽  
Author(s):  
S. T. Bonvallet ◽  
M. Oka ◽  
M. Yano ◽  
M. R. Zamora ◽  
I. F. McMurtry ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Pulmonary Circulation ◽  
Endothelin 1 ◽  
Eta Receptor ◽  
Eta Receptor Antagonist

scholarly journals Salvianolic Acid A, as a Novel ETA Receptor Antagonist, Shows Inhibitory Effects on Tumor in Vitro

2016 ◽  
Vol 17 (8) ◽  
pp. 1244 ◽  
Author(s):  
Qiao Zhang ◽  
Shifeng Wang ◽  
Yangyang Yu ◽  
Shengnan Sun ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Inhibitory Effects ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Eta Receptor ◽  
Eta Receptor Antagonist

Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation

2006 ◽  
Vol 543 (1-3) ◽  
pp. 14-20 ◽  
Author(s):  
Akiyoshi Someya ◽  
Hironori Yuyama ◽  
Akira Fujimori ◽  
Masashi Ukai ◽  
Shinji Fukushima ◽  
...  
Keyword(s):  
Bone Formation ◽  
Receptor Antagonist ◽  
Endothelin 1 ◽  
Eta Receptor ◽  
Eta Receptor Antagonist

BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats

1994 ◽  
Vol 266 (4) ◽  
pp. H1327-H1331 ◽  
Author(s):  
S. T. Bonvallet ◽  
M. R. Zamora ◽  
K. Hasunuma ◽  
K. Sato ◽  
N. Hanasato ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Receptor Antagonist ◽  
Resistance Index ◽  
Sprague Dawley ◽  
Hypoxic Pulmonary Hypertension ◽  
Mean Pressure ◽  
Eta Receptor ◽  
Medial Wall Thickness ◽  
Eta Receptor Antagonist

To investigate the role of endothelin-1 (ET-1) in the pathogenesis of hypoxic pulmonary hypertension, we studied the effects of a recently described endothelin-receptor antagonist (ETA), BQ123, on the development of this process. Intraperitoneal osmotic pumps were placed into 8-wk-old Sprague-Dawley rats that received either saline or BQ123 (0.15 mg/h). The rats were maintained in room air normoxia or placed in a hypobaric chamber (380 Torr) for 2 wk to induce hypoxic pulmonary hypertension. There were no hemodynamic differences between normoxic rats treated with either saline or BQ123. However, treatment with BQ123 attenuated the hypoxia-induced increase in pulmonary arterial mean pressure and total pulmonary resistance index by 60 and 87% respectively. There was also a reduction in hypoxia-induced right ventricular hypertrophy in the BQ123 group. Histological studies performed using a barium-gelatin fixation technique in hypoxic BQ123-treated animals demonstrated a decrease in medial wall thickness in arteries corresponding to the respiratory and terminal bronchioles, respectively. Similarly, there was a significant reduction in the degree of muscularization of more distal vessels at the level of alveolar ducts in BQ123-treated hypoxic rats. We conclude that the ETA-receptor antagonist BQ123 attenuates the development of hypoxic pulmonary hypertension in rats in vivo, thereby suggesting a possible contributing role for ET-1 and the ETA receptor in the pathogenesis of this process.

scholarly journals FR 139317. a specific endoihelin ETa receptor antagonist, prevents renal function deterioration in rats with reduced renal mass

1995 ◽  
Vol 67 ◽  
pp. 317
Author(s):  
Noboru Chida ◽  
Satoni Takahashi ◽  
Yoshimiisu N’akaiima ◽  
Keizo Sogabe ◽  
Yoshitada Notsu ◽  
...  
Keyword(s):  
Renal Function ◽  
Receptor Antagonist ◽  
Renal Mass ◽  
Renal Function Deterioration ◽  
Eta Receptor ◽  
Eta Receptor Antagonist

scholarly journals The ETA receptor antagonist TA-0201 inhibits ET-1-induced contraction in rat lower urinary tracts and human prostatic stromal cells

1999 ◽  
Vol 79 ◽  
pp. 271
Author(s):  
Kunio Nosaka ◽  
Kohei Kikkawa ◽  
Manabu Mitobe ◽  
Rikako Yamauchi ◽  
Katuya Nakano ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Stromal Cells ◽  
Eta Receptor ◽  
Eta Receptor Antagonist ◽  
Lower Urinary

Marked reduction of mortality in salt-loaded Dahl salt- sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859

2000 ◽  
Vol 18 (12) ◽  
pp. 1815-1823 ◽  
Author(s):  
Megumu Okada ◽  
Miho Nishino ◽  
Michihiro Saito ◽  
Takanori Ikeda ◽  
Sayuri Uehara ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Marked Reduction ◽  
Eta Receptor ◽  
Reduction Of Mortality ◽  
Eta Receptor Antagonist
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