Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: A randomised trial

Objective : Convulsive status epilepticus (CSE) is very rarely observed after ischaemic stroke. Sodium valproate (SV) is one of the agents used in the treatment of CSE, but its role still controversial, and its degree of efficacy in treating CSE that develops following stroke is unclear. Method : We evaluated 19 patients who were treated with intravenous (IV) SV (20 mg/kg, 2 mg/kg/h-12h) after diazepam. Patients’ modified Rankin scores (mRS), SE types, and changes in biochemical parameters after treatment were assessed. Results : CSE was successfully treated in 12 (63.15%) patients. Side effects such as hypotension and allergic reactions were observed in two patients. Refractory SE development was observed in 5 (29.4%) patients with high mRS (˃ 3). No significant deterioration in patients’ laboratory evaluations, conducted before and after status, was observed. Conclusion : SV may be safe and effective in the treatment of CSE observed after ischaemic stroke, especially in patients with low mRS.

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Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus

Neural Regeneration Research ◽

10.4103/1673-5374.245475 ◽

2019 ◽

Vol 14 (3) ◽

pp. 480

Author(s):

Li Jiang ◽

Peng Wu ◽

Yue Hu ◽

Xiu-Juan Li ◽

Min Cheng

Keyword(s):

Status Epilepticus ◽

Sodium Valproate ◽

Convulsive Status Epilepticus

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Management of generalised convulsive status epilepticus (SE): A prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam – Pilot study

Epilepsy Research ◽

10.1016/j.eplepsyres.2015.04.013 ◽

2015 ◽

Vol 114 ◽

pp. 52-58 ◽

Cited By ~ 52

Author(s):

R.C. Mundlamuri ◽

S. Sinha ◽

D.K. Subbakrishna ◽

P.V. Prathyusha ◽

M. Nagappa ◽

...

Keyword(s):

Status Epilepticus ◽

Pilot Study ◽

Sodium Valproate ◽

Combined Treatment ◽

Controlled Study ◽

Convulsive Status Epilepticus ◽

Randomised Controlled Study ◽

Phenytoin Sodium ◽

Randomised Controlled

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Notfallversorgung und Erstbehandlung epileptischer Anfälle im Erwachsenenalter

DMW - Deutsche Medizinische Wochenschrift ◽

10.1055/a-0660-3174 ◽

2019 ◽

Vol 144 (02) ◽

pp. 83-92

Author(s):

Johannes Schiefer ◽

Rainer Surges

Keyword(s):

Status Epilepticus ◽

Epileptic Seizures ◽

Recurrence Risk ◽

Brain Diseases ◽

Convulsive Status Epilepticus ◽

Mri Findings ◽

Safety Measures ◽

Anticonvulsant Treatment ◽

Convulsive Seizures ◽

Definition Of

AbstractSuspected epileptic seizures are a frequent cause of emergency hospital care. After single seizures, the emergency management includes safety measures and diagnostic efforts to distinguish epileptic seizures from its manifold mimics and to possibly detect acute causes of epileptic seizures. Convulsive status epilepticus requires rapid anticonvulsant treatment according to established protocols and diagnostics to rule out underlying acute brain diseases. After a first seizure, typical EEG- and MRI findings may indicate an elevated recurrence risk, thereby justifying the ultimate diagnosis of epilepsy and initiation of anticonvulsant therapy. This article reviews the recent definition of epilepsy, summarizes clinical characteristics of epileptic seizures and its mimics and provides an overview of established therapies of single convulsive seizures, convulsive status epilepticus and early care of adults after first unprovoked seizures.

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